South China is famous for its poly-metal deposits, with more than 50% of global W and Sb reserves, 20% of global Sn reserves, as well as abundant Cu-Mo-Pb-Zn-Au-Ag, Ta, Nb, REE and U deposits. This special issue consists of 21 papers, reporting recent progress on Yanshannian tectonic evolution, magmatism and ore deposits in South China, aiming at better understandings on the Mesozoic large-scale magmatism and mineralization events.