A variety of rare earth elements-bearing (REE) accessory mineral breakdowns were identified in granitic orthogneisses from the pre-Alpine basement in the Veporic Unit, Central Western Carpathians, Slovakia. The Ordovician granitic rocks were subjected to Variscan metamorphic-anatectic overprint in amphibolite facies. Chemical U-Th-Pb dating of monazite-(Ce) and xenotime-(Y) reveal their primary magmatic Lower to Middle Ordovician age (monazite: 472 ± 4 to 468 ± 6 Ma and xenotime: 471 ± 13 Ma) and/or metamorphic-anatectic Variscan (Carboniferous, Visean) age (monazite: 345 ± 3 Ma). Younger fluid-rock interactions caused breakdown of primary magmatic and/or metamorphic-anatectic monazite-(Ce), xenotime-(Y), fluorapatite and allanite-(Ce). Fluid-induced breakdown of xenotime-(Y) produced numerous tiny uraninite inclusions within the altered xenotime-(Y) domains. The monazite-(Ce) breakdown produced secondary egg-shaped coronal structures of different stages with welldeveloped concentric mineral zones. Secondary sulphatian monazite-(Ce) (up to 0.15 apfu S) occasionally formed along fluorapatite fissures. Localized fluorapatite and monazite-(Ce) recrystallization resulted in a very fine-grained, nonstoichiometric mixture of REE-Y-Fe-Th-Ca-P-Si phases. Finally, allanite-(Ce) decomposed to secondary REE carbonate minerals (members of the bastnäsite and synchysite groups) and calcite in some places. Although the xenotime alteration and formation of uraninite inclusions is believed to be the result of dissolution-reprecipitation between early magmatic xenotime and late-magmatic granitic fluids, the monazite, apatite and allanite breakdowns were driven by metamorphic hydrothermal fluids. While earlier impact of postmagmatic fluids originated probably from Permian acidic volcanic and microgranitic veins crosscutting the orthogneisses, another fluid-rock interaction event most likely occurred during Late Cretaceous metamorphism in the Veporic basement and covering rocks. This stage indicates carbon-bearing fluids precipitating the carbonate minerals.