Creutzfeldt-Jakob disease and blood transfusion

Esmonde, Thomas; Will, R. G.; Slattery, James; Silva, R. de; Knight, Richard; Matthews, W. B.; Harries-Jones, R

doi:10.1016/0140-6736(93)90068-r

Cited by 135 publications

(79 citation statements)

References 7 publications

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“…The accumulation of PrP Sc in sporadic CJD appears to be confined to the central nervous system and sensory ganglia [1,11]. There have been a number of case-control studies to investigate whether blood transfusion is a risk factor for sporadic CJD, and the evidence appears reassuring that this is not the case [12,13]. However, there have been inconstant and inconsistent descriptions of infectivity in the blood of patients with sporadic CJD (see Brown [13] for review and below for further discussion).…”

Section: Introductionmentioning

confidence: 99%

“…The predominance of the top, diglycosylated band is characteristic of variant CJD. there is no convincing evidence that iatrogenic CJD has occurred by blood transfusion or in the recipients of blood products, including plasma products [12,13]. Neuropathological studies of individuals dying with hemophilia have not revealed any cases of undiagnosed or preclinical prion disease, and there is no epidemiological evidence to indicate so far that individuals receiving large numbers of blood products or blood transfusions are at increased risk of developing iatrogenic CJD [19,20].…”

Section: Introductionmentioning

confidence: 99%

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Variant Creutzfeldt–Jakob disease and its transmission by blood

Ironside

Head

2003

Journal of Thrombosis and Haemostasis

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Summary. Variant Creutzfeldt–Jakob disease (vCJD) is a novel acquired human prion disease resulting from human exposure to the agent causing bovine spongiform encephalopathy (BSE). vCJD differs from all other human prion diseases in that the disease‐associated form of the prion protein and infectivity are present in lymphoid tissues throughout the body. Lymphoid tissues and lymphocytes are implicated in the peripheral pathogenesis of prion diseases (where infectivity may be detected during the preclinical phase of the illness), giving rise to concerns that blood and blood products may also contain infectivity, thus representing a possible source of iatrogenic spread of vCJD. These concerns have been reinforced by the recent transmission of BSE in an experimental sheep model by blood transfusion from an infected animal in the preclinical phase of the illness. Studies in other animal models suggest that most infectivity in blood may be cell‐associated, with lower levels in the plasma, and there is evidence to indicate that any infectivity present may be reduced during the process of plasma fractionation. At present, the attempts to detect disease‐associated prion protein and infectivity in buffy coat from vCJD patients have been negative, but these studies have been limited in size and in the sensitivity of the detection systems employed. Further studies are required to develop more sensitive means of detection of disease‐associated prion protein in blood; such techniques could also be employed for screening purposes, both individually and to help ascertain more precisely the likely numbers of future cases of vCJD.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Variant Creutzfeldt–Jakob disease and its transmission by blood

Ironside

Head

2003

Journal of Thrombosis and Haemostasis

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“…23,24 Several studies, carried out also in multitransfused hemophiliacs, have conclusively indicated that sporadic Creutzfeldt-Jakob disease (CJD) has not been transmitted by blood or its derivatives. [25][26][27][28] However, these data on sporadic CJD cannot be taken as complete reassurance, because the agent of VCJD is a new emerging agent with limited epidemiological information. The tissue distribution of the agent of VCJD is different; the incubation period is different; and the number of blood donors potentially incubating the disease may be much higher than that of donors incubating sporadic CJD.…”

Section: Plasma-derived Factorsmentioning

confidence: 99%

Ham-Wasserman Lecture

Mannucci¹

2002

Hematology

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“…Epidemiological evidence indicates that approximately 10–15% of all cases of classical CJD have previously acted as blood donors [8]. A significant number of recipients must have been transfused with labile blood products derived from patients incubating CJD and a much larger cohort must have received potentially contaminated blood components produced from plasma pools.…”

Section: Epidemiological Studiesmentioning

confidence: 99%

Creutzfeldt–Jakob Disease and the Risk from Blood or Blood Products

Will

Kimberlin²

1998

Vox Sanguinis

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The occurrence of iatrogenic cases of Creutzfeldt–Jakob disease (CJD) and the isolation of infectivity in some laboratory transmission studies in transmissible spongiform encephalopathies raises the possibility that CJD might be accidentally transmissible through blood or blood products. Epidemiological evidence, although not conclusive, does not suggest that classical CJD is transmitted through this route. However, new variant CJD (nvCJD) might pose greater risks of accidental transmission of infection and mechanisms to reduce the theoretical risk are under consideration. The theoretical risks from CJD and nvCJD must be balanced against the established therapeutic benefits of blood and blood products.

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Creutzfeldt-Jakob disease and blood transfusion

Cited by 135 publications

References 7 publications

Variant Creutzfeldt–Jakob disease and its transmission by blood

Variant Creutzfeldt–Jakob disease and its transmission by blood

Ham-Wasserman Lecture

Creutzfeldt–Jakob Disease and the Risk from Blood or Blood Products

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Creutzfeldt-Jakob disease and blood transfusion

Cited by 135 publications

References 7 publications

Variant Creutzfeldt–Jakob disease and its transmission by blood

Variant Creutzfeldt–Jakob disease and its transmission by blood

Ham-Wasserman Lecture

Creutzfeldt&ndash;Jakob Disease and the Risk from Blood or Blood Products

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Creutzfeldt–Jakob Disease and the Risk from Blood or Blood Products