CRH as a Predictor of Preterm Birth in Minority Women

Ruiz, René A.; Gennaro, Susan; O’Connor, Caitlin; Dwivedi, Alok; Gibeau, Anne; Keshinover, Tayra; Welsh, T. M.

doi:10.1177/1099800415611248

Cited by 25 publications

(21 citation statements)

References 25 publications

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“…As described in detail elsewhere (Ruiz, Dolbier, & Fleschler, ; Ruiz et al,, , ), biomarker samples were obtained from blood drawn from a peripheral vein into an EDTA‐treated vacutainer between 2 and 4 PM to avoid confounding effects of diurnal rhythms. All biomarkers were measured by enzyme‐linked immunosorbent assay, but CRH was analyzed with radioimmunoassay (for complete details, refer to Ruiz, Marti, et al, 2012; Ruiz, Stowe, et al, 2012; Ruiz et al, ).…”

Section: Methodsmentioning

confidence: 99%

Network Structure of Perinatal Depressive Symptoms in Latinas: Relationship to Stress and Reproductive Biomarkers

Santos

Fried

Asafu‐Adjei

et al. 2017

Research in Nursing & Health

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Based on emerging evidence, mood disorders can be plausibly conceptualized as networks of causally interacting symptoms, rather than as latent variables of which symptoms are passive indicators. In an innovative approach in nursing research, we used network analysis to estimate the network structure of 20 perinatal depressive (PND) symptoms. Then, two proof-of-principle analyses are presented: Incorporating stress and reproductive biomarkers into the network, and comparing the network structure of PND symptoms between non-depressed and depressed women. We analyzed data from a cross-sectional sample of 515 Latina women at the second trimester of pregnancy and estimated networks using regularized partial correlation network models. The main analysis yielded five strong symptom-to-symptom associations (e.g., cry—sadness), and five symptoms of potential clinical importance (i.e., high centrality) in the network. In exploring the relationship of PND symptoms to stress and reproductive biomarkers (proof-of-principle analysis 1), a few weak relationships were found. In a comparison of non-depressed and depressed women’s networks (proof-of-principle analysis 2), depressed participants had a more connected network of symptoms and markers overall, but the networks did not differ in types of relationships (the network structures). We hope this first report of PND symptoms as a network of interacting symptoms will encourage future network studies in the realm of PND research, including investigations of symptom-to-biomarker mechanisms and interactions related to PND. Future directions and challenges are discussed.

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Section: Methodsmentioning

confidence: 99%

Network Structure of Perinatal Depressive Symptoms in Latinas: Relationship to Stress and Reproductive Biomarkers

Santos

Fried

Asafu‐Adjei

et al. 2017

Research in Nursing & Health

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“…Human studies have shown that abnormal thyroid hormone levels, including hyperthyroidism and hypothyroidism, are associated with preterm birth [4–10] and low birth weight [11–13]. CRH is thought to play a major role in the timing of labor and has been shown to be associated with preterm birth in human studies [14–20]. Women with hyperandrogenic conditions such as polycystic ovarian syndrome have higher circulating levels of testosterone, and these types of conditions have been shown to be associated with preterm birth [21].…”

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confidence: 99%

Associations of Phthalates and Phthalate Replacements With CRH and Other Hormones Among Pregnant Women in Puerto Rico

Cathey

Watkins

Rosario

et al. 2019

Journal of the Endocrine Society

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Context Phthalates are endocrine-disrupting chemicals that may be associated with adverse birth outcomes. Dysregulation of maternal endocrine homeostasis could be a possible biological pathway between phthalates and birth outcomes. Objective Examine associations between 19 maternal urinary phthalate or phthalate replacement metabolites and 9 serum hormones measured over two time points during pregnancy. Design Longitudinal study conducted in the PROTECT pregnancy cohort. Setting Puerto Rico. Patients Six hundred seventy-seven women in the first trimester of pregnancy. Main Outcome Measures Serum CRH, estriol, SHBG, progesterone, TSH, total T3, free T4, total T4, and testosterone. Results T3 was significantly associated with most metabolites. CRH was inversely associated with mono carboxyisononyl phthalate [MCNP; percent change (% Δ ), −4.08; 95% CI, −7.24, −0.804], mono-3-carboxypropyl phthalate (MCPP; % Δ , −5.25; 95% CI, −8.26, −2.14), mono-2-ethyl-5-carboxypentyl phthalate (MECPP; % Δ , −18.4; 95% CI, −30.4, −4.37), mono-2-ethyl-5-hydroxyhexyl phthalate (MEHHP; % Δ , −13.4; 95% CI, −22.7, −2.92), and mono-2-ethyl-5-oxohexyl phthalate (MEOHP; % Δ , −12.7; 95% CI, −22.2, −2.20). Positive associations were found between numerous phthalate metabolites and free T4, T4, and the T3/T4 ratio. Testosterone was positively associated with mono hydroxybutyl phthalate (MHBP; % Δ , 4.71; 95% CI, 0.27, 9.35) and inversely associated with monoethyl phthalate (MEP; % Δ , −14.5; 95% CI, −24.3, −3.42), and relationships with MCNP and mono carboxyisooctyl phthalate (MCOP) were significantly modified by study visit. Finally, an inverse association was found between mono-2-ethyl-5-hydrohexyl terephthalate (MEHHTP), a terephthalate metabolite, and progesterone at visit 3 only (% Δ , −13.1; 95% CI, −22.3, −2.75). Conclusions These results indicate that exposure to phthalates may differentially impact the maternal endocrine system at different points during pregnancy, and that exposures to phthalate replacement chemicals may be particularly important to consider in future human health studies.

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“…This diversity is important in studying CRH as some have demonstrated its predictive capabilities differ with certain racial and ethnic group. 20 Limitations to the study include its evaluation of a single sample value as well as the variations in which CRH measurements (not a commonly run bioassay in diagnostic practice) can be obtained and measured-questioning the external validity of our results. 19 In addition, our sample looked at the mean levels of CRH and was unable to account for the bioavailable levels of CRH.…”

Section: Discussionmentioning

confidence: 94%

Association between Maternal Serum Hormones along the Maternal–Fetal Hypothalamic–Pituitary–Adrenal Axis and Successful Vaginal Delivery Measured Prior to Labor Induction

et al. 2020

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Objective This study aimed to evaluate if maternal serum hormones along the maternal–fetal hypothalamic–pituitary–adrenal (HPA) axis, when drawn prior to labor induction, differed between women who delivered vaginally and those who underwent cesarean. Study Design This was a prospective observational study at a single perinatal center performed from August 2017 to May 2018. Nulliparous women with uncomplicated singleton pregnancies ≥39 weeks had maternal serum collected prior to induction. Corticotrophin-releasing hormone (CRH) was measured by ELISA; dehydroepiandrosterone sulfate (DHEA-S), cortisol, estriol (E3) estradiol (E2), and progesterone (P4) were measured by chemiluminescent reaction. Mean analyte concentrations as well as three ratios (E2/P4, E3/P4, and E2/E3) were compared between women who had a vaginal versus cesarean delivery. Logistic regression was used to model the relationship between CRH and the odds of vaginal birth. We estimated that a sample size of 66 would have 90% power to detect a 25% difference in mean CRH levels assuming a vaginal:cesarean ratio of 2:1 with a baseline CRH concentration of 140 (standard deviation = 36) pg/mL. Results Of the 88 women who had their serum analyzed, 27 (31%) underwent cesarean. Mean maternal serum CRH levels were similar between the vaginal delivery and cesarean groups (122.6 ± 95.2 vs. 112.3 ± 142.4, p = 0.73). Similarly, there were no significant differences in any other maternal serum analytes or ratios. Logistic regression showed a nonsignificant odds ratio for successful vaginal birth (p = 0.69) even when evaluating only the 16 women who had a cesarean for an arrest disorder (p = 0.08). Conclusion In low-risk nulliparous women undergoing full-term labor induction, there were no differences noted in a broad array of other maternal-fetal HPA-axis hormones between women who had a vaginal or cesarean delivery.

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CRH as a Predictor of Preterm Birth in Minority Women

Cited by 25 publications

References 25 publications

Network Structure of Perinatal Depressive Symptoms in Latinas: Relationship to Stress and Reproductive Biomarkers

Network Structure of Perinatal Depressive Symptoms in Latinas: Relationship to Stress and Reproductive Biomarkers

Associations of Phthalates and Phthalate Replacements With CRH and Other Hormones Among Pregnant Women in Puerto Rico

Association between Maternal Serum Hormones along the Maternal–Fetal Hypothalamic–Pituitary–Adrenal Axis and Successful Vaginal Delivery Measured Prior to Labor Induction

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