Cribado de cáncer de cabeza y cuello en pacientes candidatos a trasplante hepático

Castillo-Ledesma, Nathalia; Corriols-Noval, Patricia; López-Simón, Eugenia; Viana-Cora, Aiara; Casafont-Morencos, Fernando; Ezcurra-Acedo, Iranzu; Morales‐Angulo, Carmelo

doi:10.1016/j.otorri.2020.02.003

Cited by 5 publications

(3 citation statements)

References 9 publications

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“…The overall prevalence of HNSCC was low in our cohort of screened patients, 0.2% (two out of 1099 patients), in line with former observations in LT candidates. 10,11 Excessive alcohol or tobacco consumption has been previously related to the finding of HNSCC in LT candidates, 10,11 but this combination of risk factors was present in only one of the two patients.…”

Section: Discussionmentioning

confidence: 94%

“…Previous studies on ear, nose, and throat (ENT) screening in liver transplant candidates demonstrated that 0.17%–1.3% of the patients were diagnosed with head and neck cancer, 10,11 while cases of sinusitis were more prevalent, ranging from 2.8 to 11.1 % 12,13 . However, none of these studies assessed both infections and neoplasms, and they were hampered by limited sample size.…”

Section: Introductionmentioning

confidence: 99%

“…5 Furthermore, alcohol abuse is often accompanied by smoking 6 and at least 75% of HNSCC are attributable to the combination of alcohol and tobacco consumption. 7 In addition, long-term administration of immunosuppressive agents can increase the risk of developing head and neck cancer after LT. 8,9 Previous studies on ear, nose, and throat (ENT) screening in liver transplant candidates demonstrated that 0.17%-1.3% of the patients were diagnosed with head and neck cancer, 10,11 while cases of sinusitis were more prevalent, ranging from 2.8 to 11.1 %. 12,13 However, none of these studies assessed both infections and neoplasms, and they were hampered by limited sample size.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of ear, nose, and throat‐screening in liver transplantation candidates: A retrospective cohort study

Beukman,

van der Meer,

Takkenberg

et al. 2023

Transplant Infectious Dis

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BackgroundPatients with end‐stage liver disease can be treated with a liver transplantation (LT). Before listing, candidates are subjected to a screening procedure according to the EASL Clinical Practice Guidelines for LT. In our hospital, this includes an ear, nose, and throat (ENT) examination, directed towards the identification of (asymptomatic) infections and head and neck malignancies.MethodsWe retrospectively reviewed all ENT screening examinations in LT candidates from 2007 to 2022. The screening consisted of a visit to the ENT outpatient clinic combined with sinus radiography.ResultsENT screening was performed in 1099 patients. Sixty‐one cases were identified, either diagnosed with an infection (n = 58, almost exclusively sinusitis) or a neoplasm (n = 3, of which two malignancies). With binary logistic regression, we could not identify significant risk factors for diagnosing sinusitis. 711 patients underwent LT. After LT, two patients developed a novel malignancy of the head and neck area, while 14 patients were diagnosed with sinusitis, two of the latter already showed opacification on sinus radiography during screening. Despite immunosuppressive drugs, no complicated sinusitis was observed.ConclusionSinusitis or a neoplasm was diagnosed in almost 6% in a large cohort of LT candidates. Although almost a third of sinusitis patients were not treated accordingly, we did not observe any complicated sinusitis after LT. A more conservative approach to sinusitis may therefore be justified in LT candidates, especially in asymptomatic cases. At our institution, we aim to refer only those patients with specific ENT complaints image.

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