Cribriform adenocarcinoma of minor salivary glands

Appukutty, Sona J.; Palma, Silvia; Daborn, Louise; Bagwan, Izhar; Beeslaar, Salome

doi:10.1016/j.mpdhp.2015.07.002

Cited by 5 publications

(4 citation statements)

References 7 publications

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“…Since metastases to the neck lymph nodes are rare in PAC, neck dissection should generally be performed only in case of positive lymph nodes, observed clinically and/or on imaging [44,76]. For PAC at the base of the tongue [46] and CAMSG [116], bilateral elective selective neck dissection of levels II-III-IV can be considered, given the propensity for cervical nodal metastases [117].…”

Section: Surgerymentioning

confidence: 99%

Polymorphous adenocarcinoma of the salivary glands: reappraisal and update

Poorten

Triantafyllou

Skálová

et al. 2018

Eur Arch Otorhinolaryngol

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Although relatively rare, polymorphous adenocarcinoma (PAC) is likely the second most common malignancy of the minor salivary glands (MiSG). The diagnosis is mainly based on an incisional biopsy. The optimal treatment comprises wide surgical excision, often with adjuvant radiotherapy. In general, PAC has a good prognosis. Previously, PAC was referred to as polymorphous low-grade adenocarcinoma (PLGA), but the new WHO classification of salivary gland tumours has also included under the PAC subheading, the so-called cribriform adenocarcinoma of minor salivary glands (CAMSG). This approach raised controversy, predominantly because of possible differences in clinical behaviour. For example, PLGA (PAC, classical variant) only rarely metastasizes, whereas CAMSG often shows metastases to the neck lymph nodes. Given the controversy, this review reappraises the definition, epidemiology, clinical presentation, diagnostic work-up, genetics, treatment modalities, and prognosis of PAC of the salivary glands with a particular focus on contrasting differences with CAMSG.

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Section: Surgerymentioning

confidence: 99%

Polymorphous adenocarcinoma of the salivary glands: reappraisal and update

Poorten

Triantafyllou

Skálová

et al. 2018

Eur Arch Otorhinolaryngol

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“…Since then other cases of CATs with clinical followup have been reported in the literature and it has been recognized at other intraoral locations besides the tongue (Table 1) [34][35][36][37][38][39][40][41][42][43][44][45][46][47]. The latter has led to the proposed name cribriform adenocarcinoma of minor salivary gland origin (CAMSG) [36].…”

Section: The Origin Of Cribriform Adenocarcinoma Of the Tongue (Cat)mentioning

confidence: 99%

“…Regardless of the location the reported cases have aimed to highlight the importance of separating cribriform adenocarcinoma from PLGA due to its increased rate of lymph node metastasis. In summary, the published cases as CASG show a predilection to occur in the tongue; however tumors arising in the parotid and sinonasal tract have been described [27,[34][35][36][37][38][39][40][41][42][43][44][45][46][47]. A key clinical feature that have been recurrently reported is that more than half of the patients have lymph node metastasis at time of presentation and in many instances a neck mass was the initial symptom of the patients [27,[34][35][36][37][38][39][40][41][42][43][44][45][46][47].…”

Section: The Origin Of Cribriform Adenocarcinoma Of the Tongue (Cat)mentioning

confidence: 99%

“…In summary, the published cases as CASG show a predilection to occur in the tongue; however tumors arising in the parotid and sinonasal tract have been described [27,[34][35][36][37][38][39][40][41][42][43][44][45][46][47]. A key clinical feature that have been recurrently reported is that more than half of the patients have lymph node metastasis at time of presentation and in many instances a neck mass was the initial symptom of the patients [27,[34][35][36][37][38][39][40][41][42][43][44][45][46][47]. The local recurrence rate and distant metastatic potential is rare and only two reported patients have died from disease [27,[34][35][36][37][38][39][40][41][42][43][44][45][46][47].…”

Section: The Origin Of Cribriform Adenocarcinoma Of the Tongue (Cat)mentioning

confidence: 99%

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Historical Evolution of the Polymorphous Adenocarcinoma

Hernández-Prera

2018

Head and Neck Pathol

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The 2017 World Health Organization Classification of Head and Neck Tumors introduced for the first time the diagnostic terminology "cribriform variant of polymorphous adenocarcinoma". This nomenclature attempts to reconciliate the ongoing taxonomical controversy related to cribriform adenocarcinoma of tongue. In order to better understand this classification conundrum, it is imperative for pathologist to comprehend the historical evolution of polymorphous adenocarcinoma formerly known as polymorphous "low grade" adenocarcinoma. This review highlights our understanding of these tumors since their origins.

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