Crimean-Congo haemorrhagic fever virus in Hyalomma impeltatum ticks from North Kordofan, the Sudan

Chiţimia-Dobler, Lidia; Issa, Makarim Habeeb; Ezalden, Malaz Esamalden; Yagoub, I. A.; Abdalla, M. A.; Bakhiet, Amel O.; Schaper, Sabine; Rieß, Ramona; Vollmar, Patrick; Grumbach, Anne; Bestehorn, Malena; Antwerpen, Markus; Dobler, Gerhard; Shuaib, Yassir Adam

doi:10.1016/j.ijid.2019.09.012

Cited by 9 publications

(5 citation statements)

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“…Additionally, in Senegal, R. evertesi evertesi had been found to be a competent vector for CCHFV transmission [ 9 ]. Unlike Ghana [ 28 ], Sudan [ 29 ], and Kenya [ 30 ], CCHFV was not detected in ticks of the Rhipicephalus genus, suggesting different evolutionary pressures may be associated with regional vectors.…”

Section: Discussionmentioning

confidence: 99%

Crimean–Congo Hemorrhagic Fever Virus Survey in Humans, Ticks, and Livestock in Agnam (Northeastern Senegal) from February 2021 to March 2022

et al. 2022

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Crimean–Congo hemorrhagic fever virus (CCHFV) is widespread in Asia, Europe, and Africa. In Senegal, sporadic cases of CCHFV have been reported since 1960. Bordering Mauritania in northeastern Senegal, Agnam is an arid area in the region of Matam where CCHFV is endemic, which harbors a pastoralist community. Given the drought conditions of Agnam, inhabitants are in constant movement with their animals in search of pasture, which brings them into contact with pathogens such as arboviruses. To identify CCHFV in this area, we established a One Health site in order to analyze animal livestock, ticks and human samples collected over a one-year period by qRT-PCR and ELISA. Our analysis showed one (1/364) patient carried anti-CCHFV IgM and thirty-seven carried anti-CCHFV IgG (37/364). In livestock, anti-CCHFV IgG was detected in 13 (38.24%) of 34 sentinel sheep. The risk of CCHFV infection increased significatively with age in humans (p-value = 0.00117) and sheep (p-value = 1.18 × 10−11). Additional risk factors for CCHFV infection in sheep were dry seasons (p-value = 0.004) and time of exposure (p-value = 0.007). Furthermore, we detected a total of three samples with CCHFV RNA within Rhipicephalus evertsi evertsi and Rhipicephalus guilhoni tick species. Our results highlighted the usefulness of a One Health survey of CCHFV in pastoral communities at risk of arboviruses.

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Section: Discussionmentioning

confidence: 99%

Crimean–Congo Hemorrhagic Fever Virus Survey in Humans, Ticks, and Livestock in Agnam (Northeastern Senegal) from February 2021 to March 2022

et al. 2022

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“…Indeed, Hyalomma marginatum is the most studied and known vector of CCHFV in Europe and Asia where it is responsible of the transovarian and transstadial transmission of the virus, ensuring, therefore, its maintenance in nature ( Spengler et al., 2016 ). In Africa, the virus has been detected on numerous occasions in H. dromedarii, H. truncatum, H. rufipes and H. impeltatum ( Swanepoel et al., 1983 ; Zivcec et al., 2017 ; Chitimia-Dobler et al., 2019 ; Kajihara et al., 2021 ; Schulz et al., 2021 ) but also in non Hyalomma species ( Lule et al., 2022 ). In our study, CCHFV was found in H. truncatum , although at a low infection rate but not in H. rufipes , H. impeltatum , H. nitidum, H. detritum , and H. dromaderii.…”

Section: Discussionmentioning

confidence: 99%

Molecular and serological evidence of Crimean-Congo hemorrhagic fever orthonairovirus prevalence in livestock and ticks in Cameroon

Tchetgna

Yousseu

Cosset

et al. 2023

Front. Cell. Infect. Microbiol.

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IntroductionDespite a high fatality rate in humans, little is known about the occurrence of Crimean-Congo hemorrhagic fever virus (CCHFV) in Cameroon. Hence, this pioneer study was started with the aim of determining the prevalence of CCHFV in domestic ruminants and its potential vector ticks in Cameroon.MethodsA cross-sectional study was carried out in two livestock markets of Yaoundé to collect blood and ticks from cattle, sheep, and goats. CCHFV-specific antibodies were detected in the plasma using a commercial ELISA assay and confirmed using a modified seroneutralization test. Ticks were screened for the presence of orthonairoviruses by amplification of a fragment of the L segment using RT-PCR. Phylogeny was used to infer the genetic evolution of the virus.ResultsOverall, 756 plasma samples were collected from 441 cattle, 168 goats, and 147 sheep. The seroprevalence of CCHFV was 61.77% for all animals, with the highest rate found in cattle (433/441, 98.18%) followed by sheep (23/147, 15.65%), and goats (11/168, 6.55%), (p-value < 0.0001). The highest seroprevalence rate was found in cattle from the Far North region (100%). Overall, 1500 ticks of the Rhipicephalus (773/1500, 51.53%), Amblyomma (341/1500, 22.73%), and Hyalomma (386/1500, 25.73%) genera were screened. CCHFV was identified in one Hyalomma truncatum pool collected from cattle. Phylogenetic analysis of the L segment classified this CCHFV strain within the African genotype III.ConclusionThese seroprevalence results call for additional epidemiological studies on CCHFV, especially among at-risk human and animal populations in high-risk areas of the country.

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“…In this cross-sectional study, tick specimens were collected from livestock and other domestic animals in the period from January to August 2017, in North Kordofan and Kassala states, Sudan [14]. Samples were collected from three localities in the state of North Kordofan, including Sheikan, Al-Rahad, and Um-Ruwabah, and from five localities in the state of Kassala, namely Aroomah, Wagar, Kassala, West Kassala, and Khashm el Griba (Figure 1).…”

Section: Tick Collection and Identificationmentioning

confidence: 99%

“…Tick-borne pathogens of livestock, such as the causative agents of theileriosis, babesiosis and heartwater, have been circulating on the continent, often with a considerable economic cost [11][12][13]. Additionally, zoonotic TBDs, including rickettsioses, pose a serious public health problem [14,15]. Therefore, a contemporary tick and TBD surveillance is relevant in African countries.…”

Section: Introductionmentioning

confidence: 99%

Tick Fauna and Associated Rickettsia, Theileria, and Babesia spp. in Domestic Animals in Sudan (North Kordofan and Kassala States)

et al. 2020

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Ticks and tick-borne diseases (TBDs) have a major economic impact on animal production worldwide. In the present study, 2410 ticks were collected from January to August 2017 from livestock and other domestic animals in North Kordofan and Kassala, Sudan, for species identification and investigation of Rickettsia spp. and piroplasms, either individually or as pools containing up to 10 ticks by molecular methods. In total, 13 tick species were identified by morphology and 16S rDNA sequencing. The most frequent tick species were Hyalomma impeltatum (24.90%), Rhipicephalus evertsi evertsi (18.84%), Amblyomma lepidum (16.06%), and Rhipicephalus camicasi (12.49%). A pan-Rickettsia real-time PCR revealed an overall minimum infection rate (MIR) with Rickettsia spp. of 5.64% (136 positive tick pools/2410 total ticks). Rickettsia africae and Rickettsia aeschlimannii were the most frequently identified species by sequencing. Furthermore, the following highly pathogenic livestock parasites were detected: Theileria annulata, Theileria lestoquardi, Theileria equi, and Babesia caballi. The present study documented Rhipicephalus afranicus as well as Rickettsia conorii israelensis, Rickettsia massiliae, and Babesia pecorum for the first time in Sudan. These findings are significant for the animal production sector as well as in terms of One Health, as the detected Rickettsia spp. can cause serious illness in humans.

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Crimean-Congo haemorrhagic fever virus in Hyalomma impeltatum ticks from North Kordofan, the Sudan

Cited by 9 publications

References 9 publications

Crimean–Congo Hemorrhagic Fever Virus Survey in Humans, Ticks, and Livestock in Agnam (Northeastern Senegal) from February 2021 to March 2022

Crimean–Congo Hemorrhagic Fever Virus Survey in Humans, Ticks, and Livestock in Agnam (Northeastern Senegal) from February 2021 to March 2022

Molecular and serological evidence of Crimean-Congo hemorrhagic fever orthonairovirus prevalence in livestock and ticks in Cameroon

Tick Fauna and Associated Rickettsia, Theileria, and Babesia spp. in Domestic Animals in Sudan (North Kordofan and Kassala States)

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