Crimean-Congo hemorrhagic fever: a comprehensive review

Kamboj, Aman; Pathak, Himanshu

doi:10.14202/vetworld.2013.812-817

Cited by 8 publications

(8 citation statements)

References 39 publications

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“…Classical clinical features include high grade fever with chills, headache, myalgia, generalized rash, and bleeding. [ 3 ] Over the next few days, the patient may experience neurological features, such as mood swings, and may become agitated. After 2–4 days, the agitation may be replaced by mental obtundation and altered sensorium.…”

Section: Discussionmentioning

confidence: 99%

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Crimean-Congo hemorrhagic fever: An emerging threat for the intensivist

Bhanot

Khanna

Talwar

2015

Indian Journal of Critical Care Medicine

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We present the case of a 55-year-old female, who presented with 15 days of fever with rash, pancytopenia, and altered behavior. She was investigated for routine causes of fever with rash and multi organ dysfunction and treated for the same. As she tested negative for all routine causes of such an illness and did not show improvement to therapy, she was investigated for Crimean-Congo hemorrhagic fever and tested positive for the same. She was started on ribavirin, but eventually succumbed to her illness. This disease has rarely been reported from the Northern India and we need to have high clinical suspicion for this deadly disease so that appropriate therapy can be started in time for the patient and prophylaxis given to all inadvertently exposed.

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Section: Discussionmentioning

confidence: 99%

“…Later in the course of the disease, in people surviving, antibodies can be found in the blood. [ 3 ] General supportive therapy and maintenance of vital parameters is the mainstay of patient management in CCHF. Blood component replacement and hydration are usually required.…”

Section: Discussionmentioning

confidence: 99%

Crimean-Congo hemorrhagic fever: An emerging threat for the intensivist

Bhanot

Khanna

Talwar

2015

Indian Journal of Critical Care Medicine

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“…The genome, around 19.2 kb, consists of three segments of negative sense single stranded RNA segments designated as Large (L), Medium (M) and Small (S) and encode for viral polymerase. 4 CCHF as a disease was first described in humans in the 1940s when soldiers re-occupying abandoned farmland in the Crimea became ill with a hemorrhagic disease. In the late 1960s, it was discovered that the causative agent of this hemorrhagic disease in the Crimea was similar to the causative agent of hemorrhagic disease in the Belgian Congo (current Democratic Republic of the Congo), and the name "Crimean-Congo hemorrhagic fever virus" was ascribed to the pathogen.…”

Section: Causesmentioning

confidence: 99%

“…Aerosol or airborne infection is also reported in Russia. There may be horizontal transmission from a mother to her child which indicates the need of preventive measures for in-house outbreaks of CCHF 4 . Vertical transmission: Tick vectors of CCHFV show the transfer of virus from adult females to males during fertilisation and from adult females to their eggs.…”

Section: Transmissionmentioning

confidence: 99%

An Overview of Crimean Congo Hemorrhagic Fever

Jakkula¹,

Nallagasha²,

Kadarla³

2019

WJCMPR

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Crimean Congo hemorrhagic fever (CCHF) is a zoonotic disease. It is caused by an RNA virus in wild and domestic mammals, birds and ticks. It is the family of Bunyaviridae from Arbovirus group. The main vector and reservoir of CCHF virus are hard-body ticks principally of the Hyalommagenus. The Hyalomma tick bite infection has the highest rate of nosocomial transmission especially due to direct human to human contact .India reported its first CCHF case in the year 2011 from Ahmadabad, Gujarat. Since then, several sporadic cases and outbreaks of CCHF have been reported the most from Gujarat and few from Rajasthan and Uttar Pradesh States of India .Animals do not show clinical signs but may act as a source of infection for humans. The virus is transmitted from animals to humans either by direct contact with blood or tissue of infected animal. Laboratory tests used to diagnose CCHF include reverse transcriptase (RT)-PCR, immunofluorescence assay (IFA), antibody (IgG, IgM) and antigen-capture ELISA, and isolation of virus. Ribavirin acts as effective anti-viral agent against CCHFV by inhibiting its replication. Supportive therapy including the administration of erythrocytes, thrombocytes, and fresh frozen plasma acts as an important strategy to control CCHF at an early stage. potential, high case fatality ratio (10-40%), and difficulties in

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“…The distribution of CCHFV coincides with the distribution of the main vectors, ticks of the genus Hyalomma. CCHF is asymptomatic in infected animals but case fatality can reach up to 80% in humans (Watts et al, 1989;Appannanavar and Mishar, 2011;Kamboj and Pathak, 2013).…”

Section: Introductionmentioning

confidence: 99%

Cross-sectional survey of Crimean-Congo hemorrhagic fever virus in the sultanate of Oman

Body¹,

Abdulmajeed²,

Hammad³

et al. 2016

J. Vet. Med. Anim. Health

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Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne hemorrhagic disease caused primarily by a zoonotic virus. The disease may cause a fatal hemorrhagic illness in human; however, CCHF is asymptomatic in infected animals. After the recent reports of CCHF in Oman, a cross-sectional survey was conducted during 2013 to 2014 to study the prevalence in livestock and ticks in order to assess the potential risk of emergence. 1289 serum samples were collected from different domestic animals, and tested by two types of modified ELISA (Indirect and competitive ELISA) for detection of CCHF specific immunoglobulin G (IgG). A prevalence of 7.1% positive serum samples was recorded. Highest individual prevalence was recorded in cattle (17.5%) followed by camels (15.7 %), goat (4.8%) and sheep (4.3%). Moreover, 174 ticks were also collected from 179 location. In total, 9 tick samples were found positive for CCHF virus by Antigen-capture ELISA test and RT-PCR which represents 5.1%. Moreover, the concomitant findings of positive sera for animals and detection of CCHF virus was reverse transcription polymerase chain reaction (RT-PCR). This study aims to estimate the disease distribution in livestock in Oman, identify areas under high risk, and contemplate a comprehensive control strategy.

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Crimean-Congo hemorrhagic fever: a comprehensive review

Cited by 8 publications

References 39 publications

Crimean-Congo hemorrhagic fever: An emerging threat for the intensivist

Crimean-Congo hemorrhagic fever: An emerging threat for the intensivist

An Overview of Crimean Congo Hemorrhagic Fever

Cross-sectional survey of Crimean-Congo hemorrhagic fever virus in the sultanate of Oman

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