Crimean-congo hemorrhagic fever: Case series from a medical center in golestan province, Northeast of Iran (2004-2006)

Jabbari, Ali; Besharat, Sima; Abbasi, Abdollah; Moradi, A; Kalavi, Khodaberdi

doi:10.4103/0019-5359.26609

Cited by 27 publications

(24 citation statements)

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“…Ten years later, 3 CCHF patients in Pakistan were treated with ribavirin and appeared to respond rapidly to therapy (Fisher-Hoch et al, 1995). Apparently beneficial results were subsequently described in observational studies from Iran and Turkey, which lacked control groups (Smego et al, 2004;Jabbari et al, 2006;Midilli et al, 2007).…”

Section: Ribavirinmentioning

confidence: 99%

Crimean-Congo hemorrhagic fever: History, epidemiology, pathogenesis, clinical syndrome and genetic diversity

et al. 2013

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Bente, Dennis A.; Forrester, Naomi L.; Watts, Douglas M.; McAuley, Alexander J.; Whitehouse, Chris A.; and Bray, Mike, "CrimeanCongo hemorrhagic fever: History, epidemiology, pathogenesis, clinical syndrome and genetic diversity" (2013 b s t r a c tCrimean-Congo hemorrhagic fever (CCHF) is the most important tick-borne viral disease of humans, causing sporadic cases or outbreaks of severe illness across a huge geographic area, from western China to the Middle East and southeastern Europe and throughout most of Africa. CCHFV is maintained in vertical and horizontal transmission cycles involving ixodid ticks and a variety of wild and domestic vertebrates, which do not show signs of illness. The virus circulates in a number of tick genera, but Hyalomma ticks are the principal source of human infection, probably because both immature and adult forms actively seek hosts for the blood meals required at each stage of maturation. CCHF occurs most frequently among agricultural workers following the bite of an infected tick, and to a lesser extent among slaughterhouse workers exposed to the blood and tissues of infected livestock and medical personnel through contact with the body fluids of infected patients. CCHFV is the most genetically diverse of the arboviruses, with nucleotide sequence differences among isolates ranging from 20% for the viral S segment to 31% for the M segment. Viruses with diverse sequences can be found within the same geographic area, while closely related viruses have been isolated in far distant regions, suggesting that widespread dispersion of CCHFV has occurred at times in the past, possibly by ticks carried on migratory birds or through the international livestock trade. Reassortment among genome segments during co-infection of ticks or vertebrates appears to have played an important role in generating diversity, and represents a potential future source of novel viruses. In this article, we first review current knowledge of CCHFV, summarizing its molecular biology, maintenance and transmission, epidemiology and geographic range. We also include an extensive discussion of CCHFV genetic diversity, including maps of the range of the virus with superimposed phylogenetic trees. We then review the features of CCHF, including the clinical syndrome, diagnosis, treatment, pathogenesis, vaccine development and laboratory animal models of CCHF. The paper ends with a discussion of the possible future geographic range of the virus. For the benefit of researchers, we include a Supplementary Table listing all published reports of CCHF cases and outbreaks in the English-language literature, plus some principal articles in other languages, with total case numbers, case fatality rates and all CCHFV strains on GenBank.

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Section: Ribavirinmentioning

confidence: 99%

Crimean-Congo hemorrhagic fever: History, epidemiology, pathogenesis, clinical syndrome and genetic diversity

et al. 2013

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“…Middle East and sometimes, cases of human infection to form of sporadic and outbreaks occurs in some countries of the region as Pakistan, Iraq, Afghanistan and Islamic Republic of Iran [1][2][3][4][5][6]8,11,12,14]. livestock workers, Animal herders, slaughter houses, international travelers (with contact to livestock in endemic area) and healthcare workers in endemic areas (by contact with infectious blood) in Iran are at risk of CCHF.…”

Section: Wbc (µL)mentioning

confidence: 99%

“…CCHF can cause severe infection in humans with a fatality rate of up to 25%-30%. Typically sings are vomiting, headache, agitation, high fever, mood instability, muscular pain, thrombocytopenia, leukopenia, leukocytosis, mood instability, mental confusion, throat petechiae, nosebleeds and black stools with 1-7 days' incubation period [1,[3][4][5]. Infection has been reported in endemic areas such as Asia, Africa and Eastern Europe.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, cases of human infection with CCHF have increased, and have been reported from endemic countries: Senegal, Kenya, Mauritania, South Africa, Kosovo, Albania, Bulgaria, Greece, Georgia, Russia, Tajikistan, Turkey, Pakistan, Afghanistan and Iran [2,4,[6][7][8][9][10][11][12]. Probably, genus Hyalomma tick plays as vector role in transmitting the virus from domestic and wild animals to humans [3]. The first report for the presence of an anti-CCHF antibody among domestic and/or wild animals in Iran was in 1970.…”

Section: Introductionmentioning

confidence: 99%

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Crimean-Congo Hemorrhagic Fever: Report of Three Cases from Iran

Jamshidi¹,

Daneshi²,

Parad³

2017

J Infect Dis Ther

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Introduction: Crimean-Congo Haemorrhagic Fever (CCHF) is a viral haemorrhagic fever caused by RNA virus (Nairovirus -family: Bunyaviridae). CCHF can cause severe infection in humans with a fatality rate of up to 25%-30%. Typically sings are headache, agitation, high fever, mood instability, muscular pain, thrombocytopenia, leukopenia, leukocytosis, nosebleeds and black stools with 1-7 days' incubation period.

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“…The virus is widely distributed around the world and reports of outbreaks have recently increased. [12]…”

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Facts about Crimean-Congo hemorrhagic fever and the role of intensive care in treatment and outcome

2013

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Crimean-congo hemorrhagic fever: Case series from a medical center in golestan province, Northeast of Iran (2004-2006)

Cited by 27 publications

References 2 publications

Crimean-Congo hemorrhagic fever: History, epidemiology, pathogenesis, clinical syndrome and genetic diversity

Crimean-Congo hemorrhagic fever: History, epidemiology, pathogenesis, clinical syndrome and genetic diversity

Crimean-Congo Hemorrhagic Fever: Report of Three Cases from Iran

Facts about Crimean-Congo hemorrhagic fever and the role of intensive care in treatment and outcome

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