Crimean-Congo Hemorrhagic Fever in Albania, 2001

Papa, Anna; Bino, S.; Llagami, A.; Brahimaj, B.; Papadimitriou, Εvangelia; Pavlidou, Vassiliki; Velo, Enkelejda; Cahani, Gjyle; Hajdini, M; Pilaca, Arben; Harxhi, Arjan; Antoniadis, A.

doi:10.1007/s10096-002-0770-9

Cited by 154 publications

(108 citation statements)

References 6 publications

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“…Virus-specific antibodies have been detected in some 10-20% of livestock and humans in endemic areas (Papa et al, 2002b). In Albania, CCHF was first recognized in 1986, and sporadic cases and outbreaks have occurred since that time (Papa et al 2002a).…”

Section: Southeastern Europementioning

confidence: 99%

Crimean-Congo hemorrhagic fever: History, epidemiology, pathogenesis, clinical syndrome and genetic diversity

et al. 2013

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Bente, Dennis A.; Forrester, Naomi L.; Watts, Douglas M.; McAuley, Alexander J.; Whitehouse, Chris A.; and Bray, Mike, "CrimeanCongo hemorrhagic fever: History, epidemiology, pathogenesis, clinical syndrome and genetic diversity" (2013 b s t r a c tCrimean-Congo hemorrhagic fever (CCHF) is the most important tick-borne viral disease of humans, causing sporadic cases or outbreaks of severe illness across a huge geographic area, from western China to the Middle East and southeastern Europe and throughout most of Africa. CCHFV is maintained in vertical and horizontal transmission cycles involving ixodid ticks and a variety of wild and domestic vertebrates, which do not show signs of illness. The virus circulates in a number of tick genera, but Hyalomma ticks are the principal source of human infection, probably because both immature and adult forms actively seek hosts for the blood meals required at each stage of maturation. CCHF occurs most frequently among agricultural workers following the bite of an infected tick, and to a lesser extent among slaughterhouse workers exposed to the blood and tissues of infected livestock and medical personnel through contact with the body fluids of infected patients. CCHFV is the most genetically diverse of the arboviruses, with nucleotide sequence differences among isolates ranging from 20% for the viral S segment to 31% for the M segment. Viruses with diverse sequences can be found within the same geographic area, while closely related viruses have been isolated in far distant regions, suggesting that widespread dispersion of CCHFV has occurred at times in the past, possibly by ticks carried on migratory birds or through the international livestock trade. Reassortment among genome segments during co-infection of ticks or vertebrates appears to have played an important role in generating diversity, and represents a potential future source of novel viruses. In this article, we first review current knowledge of CCHFV, summarizing its molecular biology, maintenance and transmission, epidemiology and geographic range. We also include an extensive discussion of CCHFV genetic diversity, including maps of the range of the virus with superimposed phylogenetic trees. We then review the features of CCHF, including the clinical syndrome, diagnosis, treatment, pathogenesis, vaccine development and laboratory animal models of CCHF. The paper ends with a discussion of the possible future geographic range of the virus. For the benefit of researchers, we include a Supplementary Table listing all published reports of CCHF cases and outbreaks in the English-language literature, plus some principal articles in other languages, with total case numbers, case fatality rates and all CCHFV strains on GenBank.

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Section: Southeastern Europementioning

confidence: 99%

Crimean-Congo hemorrhagic fever: History, epidemiology, pathogenesis, clinical syndrome and genetic diversity

et al. 2013

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“…CCHF virus infects the reticuloendothelial system and frequently involves the hepatocytes, leading to icteric hepatitis [13]. CCHF is a severe hemorrhagic fever with shock, DIC, and frequent extensive bleeding [14,15,16]. Case fatality ratios from 20% to 35% have been reported, but the effects of supportive treatment on reducingthe morbidity and the mortality from CCHF can be dramatic [17].…”

Section: Discussionmentioning

confidence: 99%

Crimean congo hemorrhagic fever infection simulating thrombotic thrombocytopenic purpura

Vaziri

Navabi

Afsharian

et al. 2008

Indian J Hematol Blood Transfus

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Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne disease that may also be transmitted through person-to-person transmission by exposure to infected body fl uids. Despite its wide geographic distribution in animals, CCHF virus is rarely associated with recognized human diseases. We report the fi rst case of CCHF in Kermanshah province, Iran. Clinical presentation was characterized by fever, myalgia, and hemorrhage. The levels of liver enzymes, creatinine phosphokinase, and lactate dehydrogenase were elevated, and bleeding markers were prolonged.

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“…Sağlık personeline KKKA enfeksiyonu bulaşması ve ölümler bildirilmiştir. Pakistan'da KKKA saptanan 13 sağlık personelinden dördü, Dubai'de 1979 yılındaki bir salgında beş sağlık personelinden ikisi, Irak'ta iki sağlık çalı-şanından ikisi ölmüştür ve Arnavutluk'ta bir sağlık personelinin enfekte olduğu bildirilmiştir (7)(8)(9)(10)(11). Ülkemizde Ankara'da 2005 yılında iki sağlık çalışanı KKKA enfeksiyonu nedeniyle izlenmiş ve ölüm meydana gelmemiştir (1).…”

Section: Introductionunclassified

Knowledge and Attitudes of Healthcare Workers in Umraniye, Turkey Regarding Crimean-Congo Haemorrhagic Fever

Hıdıroğlu¹,

Önsüz²,

Topuzoğlu³

et al. 2012

Erciyes Med J

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ÖZET Objective:The study aimed to assess the knowledge and attitudes of healthcare workers in primary health care centres regarding Crimean-Congo haemorrhagic fever (CCHF) in Umraniye. Material and Methods:This cross-sectional study was conducted from July-August 2008 in 18 primary healthcare centres in the Umraniye Provincial Health Directorate. The study sample was not selected and we approached 229 healthcare workers working in these primary health care centres; 144 participants (62.8%) completed the study. Study data were collected using a three-part questionnaire including 35 questions. The data were evaluated by descriptive statistics and t-tests. Results:Of the participants (72.2% women), 68.7% thought they had sufficient knowledge about the disease. 99.3% knew the aetiological factor of CCHF is a virus, and 92.4% specified that people who go picnicking and camping without protection are a risk group. The mean CCHF knowledge points was 17.48±3.37; the mean score of doctors (18.31±3.24) was significantly higher that that of nurses (17.01±3.36, p<0.05). 72.2% thought caring for a CCHF patient was a high risk task. Conclusion:The knowledge level of healthcare workers was found to be low compared to other studies performed in Turkey. The knowledge level of doctors was higher than that of nurses. In general, the answers of healthcare workers on the attitude questions were negative.

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Crimean-Congo Hemorrhagic Fever in Albania, 2001

Cited by 154 publications

References 6 publications

Crimean-Congo hemorrhagic fever: History, epidemiology, pathogenesis, clinical syndrome and genetic diversity

Crimean-Congo hemorrhagic fever: History, epidemiology, pathogenesis, clinical syndrome and genetic diversity

Crimean congo hemorrhagic fever infection simulating thrombotic thrombocytopenic purpura

Knowledge and Attitudes of Healthcare Workers in Umraniye, Turkey Regarding Crimean-Congo Haemorrhagic Fever

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