Crimean-Congo Hemorrhagic Fever Virus, Northeastern Greece

Papa, Anna; Tzala, Evangelia; Maltezou, Helena C.

doi:10.3201/eid1701.100073

Cited by 38 publications

(38 citation statements)

References 5 publications

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“…A number of published studies have described major epidemics, community and nosocomial outbreaks, and the ecology of CCHF ( 4 , 7 , 8 , 27 – 30 ). These reports have shown that a distinct epidemiologic situation can arise in regions where the virus is endemic but also that new foci can emerge ( 10 , 31 ).…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Assays for Crimean-Congo Hemorrhagic Fever

Vanhomwegen

Alves²,

Avšič-Županc³

et al. 2012

Emerg. Infect. Dis.

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Section: Discussionmentioning

confidence: 99%

Diagnostic Assays for Crimean-Congo Hemorrhagic Fever

Vanhomwegen

Alves²,

Avšič-Županc³

et al. 2012

Emerg. Infect. Dis.

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“…Crimean-Congo hemorrhagic fever virus (CCHFV) is transmitted to humans by the bite of infected ticks ( Hyalomma spp. are the most competent vectors) or by direct contact with blood or tissues of viremic patients or animals, causing a disease characterized by fever, headache, myalgia, and hemorrhagic manifestations (Papa, 2010). If the appropriate receptors are present in the tick, following a blood meal TBEV and CCHFV enter vector host cells by endocytosis (Labuda and Nuttall, 2003; Simon et al, 2009; Garrison et al, 2013; Shtanko et al, 2014; Suda et al, 2016).…”

Section: Model Microorganismsmentioning

confidence: 99%

Tick-Pathogen Interactions and Vector Competence: Identification of Molecular Drivers for Tick-Borne Diseases

Fuente

Antunes

Bonnet

et al. 2017

Front. Cell. Infect. Microbiol.

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272

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Ticks and the pathogens they transmit constitute a growing burden for human and animal health worldwide. Vector competence is a component of vectorial capacity and depends on genetic determinants affecting the ability of a vector to transmit a pathogen. These determinants affect traits such as tick-host-pathogen and susceptibility to pathogen infection. Therefore, the elucidation of the mechanisms involved in tick-pathogen interactions that affect vector competence is essential for the identification of molecular drivers for tick-borne diseases. In this review, we provide a comprehensive overview of tick-pathogen molecular interactions for bacteria, viruses, and protozoa affecting human and animal health. Additionally, the impact of tick microbiome on these interactions was considered. Results show that different pathogens evolved similar strategies such as manipulation of the immune response to infect vectors and facilitate multiplication and transmission. Furthermore, some of these strategies may be used by pathogens to infect both tick and mammalian hosts. Identification of interactions that promote tick survival, spread, and pathogen transmission provides the opportunity to disrupt these interactions and lead to a reduction in tick burden and the prevalence of tick-borne diseases. Targeting some of the similar mechanisms used by the pathogens for infection and transmission by ticks may assist in development of preventative strategies against multiple tick-borne diseases.

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“…Crimean-Congo hemorrhagic fever (CCHF) is characterized by fever and hemorrhagic manifestations with fatality up to 30% 1 . It is endemic in focal areas in Asia, Europe and Africa, with geographic distribution following that of Hyalomma ticks, the main vectors of CCHF virus (CCHFV).…”

Section: Introductionmentioning

confidence: 99%

Recent advances in research on Crimean-Congo hemorrhagic fever

Papa

Mirazimi

Köksal

et al. 2015

Journal of Clinical Virology

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Crimean-Congo hemorrhagic fever (CCHF) is an expanding tick-borne hemorrhagic disease with increasing human and animal health impact. Immense knowledge was gained over the past 10 years mainly due to advances in molecular biology, but also driven by an increased global interest in CCHFV as an emerging/re-emerging zoonotic pathogen. In the present article we discuss the advances in research with focus on CCHF ecology, epidemiology, pathogenesis, diagnostics, prophylaxis and treatment. Despite tremendous achievements, future activities have to concentrate on the development of vaccines and antivirals/therapeutics to combat CCHF. Vector studies need to continue for better public and animal health preparedness and response. We conclude with a roadmap for future research priorities.

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Crimean-Congo Hemorrhagic Fever Virus, Northeastern Greece

Cited by 38 publications

References 5 publications

Diagnostic Assays for Crimean-Congo Hemorrhagic Fever

Diagnostic Assays for Crimean-Congo Hemorrhagic Fever

Tick-Pathogen Interactions and Vector Competence: Identification of Molecular Drivers for Tick-Borne Diseases

Recent advances in research on Crimean-Congo hemorrhagic fever

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