Crimidine (2‐chloro‐4‐(dimethylamino)‐6‐methylpyrimidine) poisoning in a dog due to ingestion of the rodenticide Castrix®

Lumeij, J. T.; Schotman, A. J. H.; Vries, H. W. de

doi:10.1080/01652176.1983.9693882

Cited by 2 publications

(1 citation statement)

References 3 publications

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“…Vitamin B 6 is involved in the synthesis of gamma-aminobutyric acid (GABA), the most important inhibitory neurotransmitter (22). In the early 1980s, the first report of a dog poisoned with crimidine appeared (26). Previously, it had only been reported in indigenous carnivores (28).…”

Section: Rodenticidesmentioning

confidence: 99%

Canine status epilepticus due to acute intoxication

Zimmermann¹,

Steinberg²,

Raith³

et al. 2010

Tierarztl Prax Ausg K

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Objectives:The purpose of this study was to describe the type of toxin ingested, clinical presentation and outcome of dogs with status epilepticus (SE) due to acute poisoning presented to a large referral veterinary hospital. Materials and methods: Retrospective case series. Medical records of all dogs suffering from SE were reviewed (Jan 1, 2002 to April 30, 2009. Results: Fourteen dogs with SE due to acute intoxication were identified. Toxicological analyses (qualitative analysis with gas chromatography/mass spectrometry; n = 11) detected poisonings with carbofuran, crimidine, paraoxone, metaldehyde, strychnine and diazinon. In the other three cases the uptake of a known poison was observed (zink phosphide, metaldehyde). None of the dogs showed evidence of neurological disease up to the day of presentation. The dogs were hospitalised for 2-10 days (median 5 days). The survival rate was 85.7%. None of the dogs experienced any more seizures after discharge (median observation period 2.6 years). Conclusion and clinical relevance: Ancillary to the acute clinical presentation, preliminary reports (possible uptake of poisonous material) and an inconspicuous medical history may suggest a tentative diagnosis. Managed adequately, these patients can have a high survival rate. Clinicians should also keep uncommon intoxications in mind.

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Section: Rodenticidesmentioning

confidence: 99%

Canine status epilepticus due to acute intoxication

Zimmermann¹,

Steinberg²,

Raith³

et al. 2010

Tierarztl Prax Ausg K

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Pyridoxine in clinical toxicology: a review

Lheureux

Penaloza

Gris

2005

European Journal of Emergency Medicine

125

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Pyridoxine (vitamin B6) is a co-factor in many enzymatic pathways involved in amino acid metabolism: the main biologically active form is pyridoxal 5-phosphate. Pyridoxine has been used as an antidote in acute intoxications, including isoniazid overdose, Gyromitra mushroom or false morrel (monomethylhydrazine) poisoning and hydrazine exposure. It is also recommended as a co-factor to improve the conversion of glyoxylic acid into glycine in ethylene glycol poisoning. Other indications are recommended by some sources (for example crimidine poisoning, zipeprol and theophylline-induced seizures, adjunct to d-penicillamine chelation), without significant supporting data. The value of pyridoxine or its congener metadoxine as an agent for hastening ethanol metabolism or improving vigilance in acute alcohol intoxication is controversial. This paper reviews the various indications of pyridoxine in clinical toxicology and the supporting literature. The potential adverse effects of excessive pyridoxine dosage will also be summarized.

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Crimidine (2‐chloro‐4‐(dimethylamino)‐6‐methylpyrimidine) poisoning in a dog due to ingestion of the rodenticide Castrix®

Cited by 2 publications

References 3 publications

Canine status epilepticus due to acute intoxication

Canine status epilepticus due to acute intoxication

Pyridoxine in clinical toxicology: a review

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