Crimson clues: advancing endometriosis detection and management with novel blood biomarkers

Gibbons, Tatjana; Rahmioglu, Nilufer; Zondervan, Krina T.; Becker, Christian M.

doi:10.1016/j.fertnstert.2023.12.018

Cited by 2 publications

(2 citation statements)

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“…Although numerous original studies and systematic reviews analysed the potential application of nearly two hundred different molecules as potential markers of endometriosis, and for some of them, a significant association with the presence or absence of endometriosis was found [ 22 , 45 , 46 ], only single markers meet the criteria of a replacement/screening test. A comparison of test criteria obtained for the best published potential diagnostic markers and Arg-1 is presented in Table 2 .…”

Section: Discussionmentioning

confidence: 99%

Determination of Serum Arginase-1 Concentrations and Serum Arginase Activity for the Non-Invasive Diagnosis of Endometriosis

Pliszkiewicz,

Czystowska-Kuzmicz,

Soroczynska

et al. 2024

JCM

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Backgroud: Endometriosis remains a diagnostic challenge, both clinically and economically, affecting 6% to 15% of women of child-bearing potential. We have attempted to determine whether testing serum concentrations and activity of arginase isoenzymes could be useful for the non-invasive diagnosis of endometriosis. Methods: This study involved 180 women (105 endometriosis subjects—study group B; 22 subjects with other benign gynaecological conditions—control group 1—K1, both undergoing surgery; and 53 healthy subjects without features of endometriosis—control group 2—K2). Results: Preoperative and postoperative arginase-1 (Arg-1) concentrations were significantly higher in patients, as compared with the control groups K1 (p < 0.0001 and p = 0.0005, respectively) and K2 (both p < 0.0001). Similarly, arginase activity was significantly higher in patients than in the control group K1 before surgery and higher than in both control groups after surgery. No significant differences in either Arg-1 concentrations or arginase activity were noted between the operated control group K1 and the non-operated control group K2. A significant postoperative decrease in Arg-1 concentration was observed within both patient (p < 0.0001) and control group K1 (p = 0.0043). Diagnostic performance was assessed using the receiver operating characteristic (ROC) method. The threshold for differentiation between endometriosis patients and healthy non-operated controls was 42.3 ng/mL, with a sensitivity of 90% and specificity of 81%. For differentiation of patients and operated controls with benign gynaecological conditions, the threshold was 78.4 ng/mL, with a sensitivity of 61% and specificity of 95%. Conclusions: We, therefore, conclude that Arg-1 serum concentrations and arginase activity could be considered potential biomarkers for endometriosis but require further studies on larger cohorts of patients.

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Section: Discussionmentioning

confidence: 99%

Determination of Serum Arginase-1 Concentrations and Serum Arginase Activity for the Non-Invasive Diagnosis of Endometriosis

Pliszkiewicz,

Czystowska-Kuzmicz,

Soroczynska

et al. 2024

JCM

View full text Add to dashboard Cite

show abstract

“…Another study looked at potential biomarkers in blood by combining markers of inflammation with genome-wide association studies (GWASs), next-generation sequencing, and machine learning. 9 Unfortunately, this study highlighted the failure of many biomarkers to achieve validation before commercialization, with most biomarkers remaining at the discovery phase.…”

Section: Main Textmentioning

confidence: 99%