Crinum L. species as a potential source of alkaloids: Extraction methods and relevance for medicinal and pharmacological applications

Araújo, Renata Lázara de; Pinho, Carolina Lilibeth Carvalho de; Farias, Fabiane Oliveira; Igarashi‐Mafra, Luciana; Mafra, Marcos R.

doi:10.1016/j.sajb.2022.10.053

Cited by 5 publications

(2 citation statements)

References 113 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These compounds are often associated with antioxidant, anti-inflammatory, and other health-promoting properties [44,45]. The presence of diverse chemical compounds, including active compounds like alkaloids, tannins, and resins, suggests that these plants may indeed have medicinal properties and potential health benefits [46,47]. Alkaloids, for instance, are known to have diverse pharmacological activities, including analgesic and antimicrobial effects.…”

Section: Phytochemical Analysismentioning

confidence: 99%

Antifungal Activity of Some Plants Used in Yemeni Herbal Medicine

Fartwat,

Salem

2023

Electron. J. Univ. Aden Basic Appl. Sci.

View full text Add to dashboard Cite

Capparis cartilaginea Decne.; Vachellia nilotica subspecies Indica (Benth) Kyal & Boatwr.; Fagonia paulayana J. Wagner & Vierh., are medicinal plants used in traditional Yemen medicine for the treatment a variety of infectious and non-infectious diseases. These plants were selected to evaluate their potential antifungal activity. To determine antifungal activity and phytochemicals in the leaves, and total vegetative extracts of three medicinal plants used in traditional Yemeni medicine for the treatment of various disease like rheumatism, piles fever, skin diseases and snake bite. Plant extracts from three species, namely Capparis cartilaginea, Vachellia nilotica subsp. Indica, and Fagonia paulayana, were prepared using ethanol and water. The extracts were tested for their antifungal activity against Candida species isolated from vaginal specimens of women. Phytochemical screening was also performed to identify various constituents in the extracts. The antifungal susceptibility testing was carried out following standard guidelines, and Amphotericin B was used as a reference antifungal agent. The study aimed to evaluate the potential of these plant extracts as natural remedies for Candida-related infections. The study evaluated the antimicrobial activity of plant extracts from Capparis cartilaginea, Vachellia nilotica subsp. Indica, and Fagonia paulayna against Candida fungal isolates from vaginal specimens. Vachellia nilotica subsp. Indica (Ethanol Extract) showed significant inhibitory effects against Candida species, while Capparis cartilaginea and Fagonia paulayna (both Ethanol Extracts) had limited inhibitory activity. Further research is needed to explore the therapeutic potential of Vachellia nilotica subsp. Indica as a natural antifungal agent. Extracts of Vachellia nilotica subsp. Indica demonstrate notable inhibitory effects against Candida species isolated from vaginal samples. This research points to the potential for using extracts of the Vachellia nilotica subsp. Indica plant as a natural remedy for Candida-associated infections.

show abstract

Section: Phytochemical Analysismentioning

confidence: 99%

Antifungal Activity of Some Plants Used in Yemeni Herbal Medicine

Fartwat,

Salem

2023

Electron. J. Univ. Aden Basic Appl. Sci.

View full text Add to dashboard Cite

show abstract

“…sinicum is used in Chinese folk medicine for treating sores, abscesses, and aching joints [17]. A methanolic extract exhibited various bioactive properties, including analgesic, antiin ammatory, cytotoxic, and anti-cancer effects [18,19]. Phytochemical studies showed that alkaloid components were the primary constituent, with phenolics and terpenoids as minor components [18,20].…”

Section: Introductionmentioning

confidence: 99%

Acetylcholinesterase inhibition studies of alkaloid components from Crinum asiaticum var. sinicum : in vitro assessments by molecular docking and molecular dynamics simulations

Duc,

Trang,

Tuan Anh

et al. 2023

Journal of Asian Natural Products Research

View full text Add to dashboard Cite

Alkaloids are among the most important and best-known secondary metabolites as sources of new drugs from medicinal plants and marine organisms. A phytochemical investigation of whole Crinum asiaticum var. sinicum plants resulted in the isolation of seven alkaloids (1-7), including one new compound (1). Their structures were elucidated using NMR and HR-ESI-MS. The absolute con guration of 1 was established by ECD. A molecular docking and molecular dynamics simulation was carried out for the isolated compounds to screen for acetylcholine (AChE) inhibitory activity. The target compounds were evaluated for their inhibitory effects on AChE activity in vitro. The results suggest that these C. asiaticum alkaloids possess the ability to treat Alzheimer's disease.

show abstract