Cripto-1: At the Crossroads of Embryonic Stem Cells and Cancer

Oncofetal Protein CR-1 in a new clinical role: a potential tumor marker for Oral Squamous Cell Carcinoma

“…It belongs to EGF-CFC (epidermal growth factorCR-1-FRL-1-Cryptic) family [19]. CR-1, like other EGF-CFC proteins, found to play a role in embryogenesis, where it functions along with nodal, TGF-β (transforming growth factor-β ) and GDF-1/GDF-3 (Growth and differentiation factor 1 and 3) as their co-receptor [20]. During embryogenesis it is found to be involved in gastrulation, specification of endoderm and mesoderm, cardiogenesis etc.…”

“…certified by peer review) (which was not The copyright holder for this preprint this version posted July 8, 2019. . https://doi.org/10.1101/19000950 doi: medRxiv preprint four major domains which are; a signal peptide domain at amino terminal, an Epidermal Growth Factor-like domain, a cysteine-rich domain and a short domain, present at carboxyl terminal (hydrophobic in nature), containing sequence for glycophosphatidylinositol (GPI) anchorage and cleavage [20]. The GPI anchorage and cleavage sequence is responsible for existence of CR-1 in two distinct forms, i.e.…”

“…In vitro studies, reporting induction of transformation of a variety of cells by overexpressed CR-1, provide the evidence of its oncogenic activity [22, 23]. Structurally, CR-1 consists of four major domains which are; a signal peptide domain at amino terminal, an Epidermal Growth Factor-like domain, a cysteine-rich domain and a short domain, present at carboxyl terminal (hydrophobic in nature), containing sequence for glycophosphatidylinositol (GPI) anchorage and cleavage [20]. The GPI anchorage and cleavage sequence is responsible for existence of CR-1 in two distinct forms, i.e.…”