Crise rénale sclérodermique : un cas clinique

Zbiti, Najoua; Houssaïni, Tarik Sqalli; Benkirane, Aicha; Alhamany, Z.; Rhou, H.; Benamar, L.; Ezaitouni, F.; Bayahia, R.; Ouzeddoun, N.

doi:10.1016/j.nephro.2010.07.002

Cited by 2 publications

(7 citation statements)

References 11 publications

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“…In 1970 estimated prevalence was between 12 to 18% [ 4 ]. The age of onset varies between 43 and 64 [ 5 – 8 ], these data fit with those of the patient No. 1 who was 45 years although the case No 2 of 32 years old was younger.…”

Section: Discussionsupporting

confidence: 77%

Scleroderma renal crisis in tropical region: two senegalese cases

Cissé¹,

Seck²,

Oumar³

et al. 2015

Pan Afr Med J

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Scleroderma renal crisis (SRC) is defined as the new onset of accelerated arterial hypertension and /or rapidly progressive oliguric renal failure during the course of systemic sclerosis. It is a rare but life-threatening complication. This formerly serious complication has got a considerable brighter outlook since the introduction of angiotensin converting enzyme inhibitors (ACE) however the mortality is still remaining high. We report two cases of SRC which to our knowledge are the firsts described in Dakar. They were two women aged 45 and 32 years, one of them was previously following for systemic sclerosis. Both of them had malignant hypertension associated with rapidly progressive renal failure, the other was put under corticosteroid therapy four months before SRC occurrence. The histological and laboratory finding showed thrombotic microangiopathy. The height blood pressure returned to normal value after treatment with ACE inhibitors. The final outcome was undesirable with the death of one after two months due to the hemodialysis discontinuation and persistence of renal failure in the other.

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Section: Discussionsupporting

confidence: 77%

Scleroderma renal crisis in tropical region: two senegalese cases

Cissé¹,

Seck²,

Oumar³

et al. 2015

Pan Afr Med J

View full text Add to dashboard Cite

show abstract

“…In 1970 estimated prevalence was between 12 to 18% [4]. The age of onset varies between 43 and 64 [5][6][7][8], these data fit with those of the patient No. 1 who was 45 years although the case No 2 of 32 years old was younger .…”

Section: Discussionsupporting

confidence: 72%

“…1 who was 45 years although the case No 2 of 32 years old was younger . There are Risk factors for SRC (Table I) [2,5,9]. Indeed, in a study by Stenn et al 25% of the patients had diffuse cutaneous involvement [2].…”

Section: Discussionmentioning

confidence: 99%

“…Anemia especially a newly developed is also considered a risk factor as it was the case for our two patients with a hemoglobin of 8 and 8.1 g / dl. Zbiti also reported a normocytic normochromic anemia with hemoglobin of 6g/dL [5]. High-dose corticosteroid therapy longer than 3 months is considered as a powerful risk factor of SRC [6,[8][9][10][11] as evidenced by case No 1 who developed a SRC after 4 months treatment with 40 mg of prednisone per day .Hypertension, usually malignant (DBP ≥ 130 mm Hg) was found in approximately 87% of patients [6,8] in its typical form.…”

Section: Discussionmentioning

confidence: 99%

“…Renal biopsies, even though necessary to confirm the diagnosis, are not routinely warranted in SRC. It must be done very carefully when the blood pressure is fully controlled and the platelet count is normal otherwise transjugular renal biopsy is more appropriate [5,13]. Prevention is the first step of SRC treatment.…”

Section: Discussionmentioning

confidence: 99%

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