Crisis occipitales con alteraciones electroencefalográficas como manifestación inicial de diabetes mellitus

Martínez, María Durán; Megías, Susana Monereo

doi:10.1016/s1575-0922(09)73314-5

Cited by 7 publications

(3 citation statements)

References 11 publications

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“…In some cases, partial seizures are the presenting feature of undiagnosed diabetes mellitus. This was initially described by Maccario and colleagues in 1965 [2] and later by others [3] , [4] , [5] . The most commonly encountered seizure types in NKH are focal motor seizures and epilepsia partialis continua [6] .…”

Section: Discussionmentioning

confidence: 80%

Occipital seizures and subcortical T2 hypointensity in the setting of hyperglycemia

Putta

Weisholtz

Milligan

2014

Epilepsy & Behavior Case Reports

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IntroductionOccipital lobe seizures are a recognized manifestation of diabetic nonketotic hyperglycemia, though not as common as focal motor seizures. Occipital lobe white matter T2 hypointensity may suggest this diagnosis.MethodsWe present a case of a 66-year-old man with hyperglycemia-related occipital lobe seizures who presented with confusion, intermittent visual hallucinations, and homonymous hemianopia.ResultsMagnetic resonance imaging showed subcortical T2 hypointensity within the left occipital lobe with adjacent leptomeningeal enhancement. These findings were transient with disappearance in a follow-up MRI. The EEG captured frequent seizures originating in the left occipital region. HbA1c level was 13.4% on presentation, and finger stick blood glucose level was 400 mg/dl.ConclusionHyperglycemia should be considered in the etiology of differential diagnosis of patients with visual abnormalities suspicious for seizures, especially when the MRI shows focal subcortical T2 hypointensity with or without leptomeningeal enhancement.

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Section: Discussionmentioning

confidence: 80%

Occipital seizures and subcortical T2 hypointensity in the setting of hyperglycemia

Putta

Weisholtz

Milligan

2014

Epilepsy & Behavior Case Reports

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“…This is concordant with our observation of an increased number of spontaneous Ca 2+ peaks in the glucose-treated larvae. Neuronal hyperexcitability and increased firing is known to be associated with seizures, commonly observed in diabetic patients (Martinez and Megias, 2009; Baviera et al, 2017). The various cellular markers shown here to be affected by glucose exposure could explain a predisposition of diabetics to seizures.…”

Section: Discussionmentioning

confidence: 99%

Sodium nitroprusside prevents the detrimental effects of glucose on the neurovascular unit and behaviour in zebrafish

Chhabria

Vouros

Gray

et al. 2019

Disease Models &Amp; Mechanisms

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Diabetes is associated with dysfunction of the neurovascular unit, although the mechanisms of this are incompletely understood and currently no treatment exists to prevent these negative effects. We previously found that the nitric oxide (NO) donor sodium nitroprusside (SNP) prevents the detrimental effect of glucose on neurovascular coupling in zebrafish. We therefore sought to establish the wider effects of glucose exposure on both the neurovascular unit and on behaviour in zebrafish, and the ability of SNP to prevent these. We incubated 4-days post-fertilisation (dpf) zebrafish embryos in 20 mM glucose or mannitol for 5 days until 9 dpf, with or without 0.1 mM SNP co-treatment for 24 h (8-9 dpf), and quantified vascular NO reactivity, vascular mural cell number, expression of a klf2a reporter, glial fibrillary acidic protein (GFAP) and transient receptor potential cation channel subfamily V member 4 (TRPV4), as well as spontaneous neuronal activation at 9 dpf, all in the optic tectum. We also assessed the effect on light/dark preference and locomotory characteristics during free-swimming studies. We find that glucose exposure significantly reduced NO reactivity, klf2a reporter expression, vascular mural cell number and TRPV4 expression, while significantly increasing spontaneous neuronal activation and GFAP expression (all in the optic tectum). Furthermore, when we examined larval behaviour, we found that glucose exposure significantly altered light/dark preference and high and low speed locomotion while in light. Co-treatment with SNP reversed all these molecular and behavioural effects of glucose exposure. Our findings comprehensively describe the negative effects of glucose exposure on the vascular anatomy, molecular phenotype and function of the optic tectum, and on whole-organism behaviour. We also show that SNP or other NO donors may represent a therapeutic strategy to ameliorate the complications of diabetes on the neurovascular unit..

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“…Epileptic seizures in diabetic patients are mostly reported as focal seizures (13,14,15,16,17,18,19) with or without secondary generalization; epilepsy partialis continua (EPC) (20,21,22,23,24,25,26,27,28), occipital seizures (29,30,31,32,33), and reflex seizures (34,35,36) have also been described. However, some cases of generalized epilepsy (childhood absence epilepsy, juvenile absence epilepsy, tonic-clonic seizures on wakening, and juvenile myoclonic epilepsy) associated with T1DM have also been reported (7,9,37,38).…”

Section: Introductionmentioning

confidence: 99%

MECHANISMS IN ENDOCRINOLOGY: Seizures and type 1 diabetes mellitus: current state of knowledge

Verrotti

Scaparrotta

Olivieri

et al. 2012

European Journal of Endocrinology

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In this review, we will try to analyze the possible coexistence between epilepsy or seizures and type 1 diabetes mellitus (T1DM), in order to establish if there is more than a casual association, and to investigate possible mechanisms underlying this link. Anti-glutamic acid decarboxylase antibodies (GAD-Abs) have been associated with T1DM and a great number of neurological diseases such as epilepsy. Epilepsy can be a feature of a large variety of autoimmune or inflammatory disorders. GAD-Abs can have a role at the basis of the possible link between epilepsy and T1DM, although their real pathogenetic mechanism in neurological diseases is still unknown. Metabolic conditions such as hypoglycemia and hyperglycemia, common problems in diabetic patients, may be also implicated, even if their underlying mechanism is minimally understood.

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Crisis occipitales con alteraciones electroencefalográficas como manifestación inicial de diabetes mellitus

Cited by 7 publications

References 11 publications

Occipital seizures and subcortical T2 hypointensity in the setting of hyperglycemia

Occipital seizures and subcortical T2 hypointensity in the setting of hyperglycemia

Sodium nitroprusside prevents the detrimental effects of glucose on the neurovascular unit and behaviour in zebrafish

MECHANISMS IN ENDOCRINOLOGY: Seizures and type 1 diabetes mellitus: current state of knowledge

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