CRISPR/Cas systems combined with DNA nanostructures for biomedical applications

Abstract

DNA nanostructures are easy to design and construct, have good biocompatibility, and show great potential in biosensing and drug delivery when combined with CRISPR/Cas systems.

Turn-on fluorescent aptasensing for the determination of serotonin via target-induced knot displacement at corona

“…6 The biosensing approach uses biologically active biomolecules, such as enzymes, antibodies and nucleic acids, as molecular recognition elements that have high selectivity for the specific target. 7 Fortunately, aptamer-based biosensing (aptasensing) methods for the detection of 5-HT are progressively advancing. In 2018, Nakatsuka et al pioneeringly reported an aptasensing strategy for the determination of 5-HT using field effect transistors based on target-induced aptamer conformational changes.…”