“…Until now, there are some monkeypox diagnostic methods that have been used for diagnosing the infections. Some of these techniques are polymerase chain reaction, , virus culture-based diagnosis, protein Cas-based diagnosis, , loop-mediated isothermal amplification, , enzyme-linked immunosorbent assay, , and recombinase polymerase amplification assay. ,, Considering the point-of-care (POC) nature of rapid tests, antibody-based immunoassays seem to be stronger diagnostic tool candidates for MPXV detection. However, due to the antigen context of Orthopoxvirus genomes, most human samples become cross-reactive, and this situation makes it impossible to differentiate different kinds of Orthopoxvirus viruses. − …”