2024
DOI: 10.3390/ijms25020823
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CRISPR/Cas9 as a Mutagenic Factor

Andrey R. Shumega,
Youri I. Pavlov,
Angelina V. Chirinskaite
et al.

Abstract: The discovery of the CRISPR/Cas9 microbial adaptive immune system has revolutionized the field of genetics, by greatly enhancing the capacity for genome editing. CRISPR/Cas9-based editing starts with DNA breaks (or other lesions) predominantly at target sites and, unfortunately, at off-target genome sites. DNA repair systems differing in accuracy participate in establishing desired genetic changes but also introduce unwanted mutations, that may lead to hereditary, oncological, and other diseases. New approache… Show more

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