CRISPR/Cas9-Mediated Gene Drive to Prevent the Replication of Dengue Virus in the Mosquito Vectors to Reduce the Impact of Dengue Epidemic in Bangladesh
Abstract:Dengue is a flavivirus transmitted by Aedes aegypti, leading to mosquito-borne illness causing significant morbidity and mortality each year. A majority of dengue cases around the world are caused by four serotypes-dengue virus (DENV) 1-4. The recent outbreak has broken all the previous record of infections with 101, 354 dengue cases, which has increased the urgency of finding an effective way to reduce the level of infection. CRISPR-Cas9 mediated gene drive is a novel technology that can be used to reduce the… Show more
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