2023
DOI: 10.1101/2023.03.17.533093
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CRISPR/Cas9-mediated knockout of the ubiquitin variant UbKEKSreveals a role in regulating nucleolar structures and composition

Abstract: Ubiquitination is a post-translational modification responsible for one of the most complex multi-layered communication and regulation system in the cell. Over the past decades, new ubiquitin variants and ubiquitin-like proteins arose to further enrich this mechanism. Among them, the recently discovered ubiquitin variant UbKEKS can specifically target several proteins and yet, functional consequences of this new modification remain unknown. The absence of UbKEKS induces accumulation of lamin A in the nucleoli,… Show more

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