CRISPR‐Cas9 technology: A new direction for personalized medicine in respiratory disease?

Vaughan, Annalicia; Yang, Ian A.

doi:10.1111/resp.13570

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…Ultimately, much research remains to be done to increase the precision of CRISPR technologies. New future projects, such as introducing regulatory molecules along with the CRISPR technology, using the body's natural repair capabilities, or engineering new secondary structures, show promise in the field of cell biology and biomedicine [67][68][69]. CRISPR Class 1 and 2 systems are depicted.…”

Section: Recent Advances In Reducing Crispr Cas9 Off-target Effectsmentioning

confidence: 99%

CRISPR-Cas9 Genome Editing in Human Cell Lines with Donor Vector Made by Gibson Assembly

Sahoo

Cuello

Udawant

et al. 2020

RNA Interference and CRISPR Technologies

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CRISPR Cas9 genome editing allows researchers to modify genesin a multitude of ways including to obtain deletions, epitope-tagged loci, and knock-in mutations. Within six years of its initial application, CRISPR Cas9 genome editing has become widely employed, but disadvantages to this method, such as low modification efficiencies and off-target effects,need careful consideration. Obtaining custom donor vectors can also be expensive and time consuming. This chapter details strategies to overcome barriers to CRISPR Cas9 genome editing as well as recent developments in employing this technique.

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Section: Recent Advances In Reducing Crispr Cas9 Off-target Effectsmentioning

confidence: 99%

CRISPR-Cas9 Genome Editing in Human Cell Lines with Donor Vector Made by Gibson Assembly

Sahoo

Cuello

Udawant

et al. 2020

RNA Interference and CRISPR Technologies

View full text Add to dashboard Cite

show abstract

Regulatory Aspects of Personalised Medicines

Dhingra

Mani

Thakkar

2021

ADCTRA

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: The advent of big data analysis, genetic engineering and epigenetics has transformed the healthcare system by shifting the strategy for diagnosis, prevention and treatment of diseases from “one-size-fits-all” approach to “personalised” approach. Identification of biomarkers from molecular diagnosis has made tailoring of the medical treatment possible. Optimization of treatment decreases the costs related to the ineffective treatments and help in avoiding possible side effects and adverse drug reactions. The efficient development of personalised medicine is largely dependent on the tools, sequencing techniques used and regulatory policies related to the personalised medicine products, tests and companion diagnostics. The uncertainties around regulations governing personalised medicine should be eliminated and specific guidelines should be laid down by the respective regulatory authorities to bridge the emerging tools and technologies with the regulatory policies. Also, proper regulatory approval pathways for companion diagnostics will resolve the complications of organized development of therapeutic products and diagnostic tests.

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CRISPR‐Cas9 technology: A new direction for personalized medicine in respiratory disease?

Abstract: See related https://onlinelibrary.wiley.com/doi/10.1111/resp.13527

Cited by 2 publications

References 10 publications

CRISPR-Cas9 Genome Editing in Human Cell Lines with Donor Vector Made by Gibson Assembly

CRISPR-Cas9 Genome Editing in Human Cell Lines with Donor Vector Made by Gibson Assembly

Regulatory Aspects of Personalised Medicines

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