CRISPR control of virulence in Pseudomonas aeruginosa

Wiedenheft, Blake; Bondy‐Denomy, Joseph

doi:10.1038/cr.2017.6

Cited by 8 publications

(4 citation statements)

References 12 publications

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“…Pseudomonas aeruginosa can also be cited as an example. It was established that the type I-F CRISPR-Cas system is able to repress some genes in order to escape the host defense immune system and reduce the amount of cytokines produced by the host (Li et al, 2016;Wiedenheft and Bondy-Denomy, 2017). With this review, we can see that this link between CRISPR-Cas systems and bacterial virulence exists also in streptococci, as proved with S. pyogenes (Nozawa et al, 2011), S. mutans (Chen et al, 2017) or S. anginosus (Bauer et al, 2020).…”

Section: Discussionmentioning

confidence: 82%

Distribution, Diversity and Roles of CRISPR-Cas Systems in Human and Animal Pathogenic Streptococci

et al. 2022

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Streptococci form a wide group of bacteria and are involved in both human and animal pathologies. Among pathogenic isolates, differences have been highlighted especially concerning their adaptation and virulence profiles. CRISPR-Cas systems have been identified in bacteria and many streptococci harbor one or more systems, particularly subtypes I-C, II-A, and III-A. Since the demonstration that CRISPR-Cas act as an adaptive immune system in Streptococcus thermophilus, a lactic bacteria, the diversity and role of CRISPR-Cas were extended to many germs and functions were enlarged. Among those, the genome editing tool based on the properties of Cas endonucleases is used worldwide, and the recent attribution of the Nobel Prize illustrates the importance of this tool in the scientific world. Another application is CRISPR loci analysis, which allows to easily characterize isolates in order to understand the interactions of bacteria with their environment and visualize species evolution. In this review, we focused on the distribution, diversity and roles of CRISPR-Cas systems in the main pathogenic streptococci.

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Section: Discussionmentioning

confidence: 82%

Distribution, Diversity and Roles of CRISPR-Cas Systems in Human and Animal Pathogenic Streptococci

et al. 2022

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“…S14 in the supplemental material) and, hence, could regulate the expression of bcsC . Such a kind of regulation is reported in Pseudomonas aeruginosa , where spacer 12 of the CRISPR-I array has partial complementarity to the lasR gene, and the lasR gene is regulated by the CRISPR array ( 57 ). CRP also activates flhDC , a flagellar master operon ( 58 ) that further activates the expression of class 2 genes, including fliA.…”

Section: Discussionmentioning

confidence: 99%

The CRISPR-Cas System Differentially Regulates Surface-Attached and Pellicle Biofilm in Salmonella enterica Serovar Typhimurium

et al. 2022

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“…Earlier studies in V. cholera had shown the co-acquisition of a (Carpenter et al, 2017). Type I-F CRISPR-cas system in Pseudomonas aeruginosa has been implicated in the regulation of virulence (Wiedenheft and Bondy-Denomy, 2017). The CRISPR-Cas system is believed to be involved in biofilm formation and swarming behaviours of P. aeruginosa (Zegans et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Antibiotic resistance pattern and its correlation to the presence of tdh gene and CRISPR-Cas system in Vibrio parahaemolyticus strains isolated from seafood

Baliga¹,

Shekar²,

Ahamed³

et al. 2019

Indian J. Fish.

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Vibrio parahaemolyticus is a pathogen native to the aquatic environment. In this study, 46 environmental V. parahaemolyticus isolates were subjected to a correlational analysis to find the association between their antimicrobial susceptibility pattern, prevalence of CRISPR-Cas system and thermostable direct hemolysin (tdh) gene. Antibiotic resistance profiling against eleven antibiotics revealed the isolates to be multidrug resistant. Isolates exhibited highest resistance to vancomycin (97.8%) followed by ampicillin (91.3%), cefotaxime (69.6%), ceftazidime/clavulanic acid (54.4%), ceftazidime (45.7%) and gentamicin (39.1%). CRISPR loci and tdh gene were detected in 47.83 and 58.7% of strains respectively. No significant correlation was observed between antibiotic resistance to presence of CRISPR, except in the case of gentamicin wherein, a negative correlation was seen (r=-0.272, p<0.10). Similarly, tdh did not correlate to antibiotic resistance. Seventeen strains in this study harboured the CRISPR loci as well as tdh gene, the association of which was found to be statistically significant.

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CRISPR control of virulence in Pseudomonas aeruginosa

Cited by 8 publications

References 12 publications

Distribution, Diversity and Roles of CRISPR-Cas Systems in Human and Animal Pathogenic Streptococci

Distribution, Diversity and Roles of CRISPR-Cas Systems in Human and Animal Pathogenic Streptococci

The CRISPR-Cas System Differentially Regulates Surface-Attached and Pellicle Biofilm in Salmonella enterica Serovar Typhimurium

Antibiotic resistance pattern and its correlation to the presence of tdh gene and CRISPR-Cas system in Vibrio parahaemolyticus strains isolated from seafood

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