Criteria and Recommendations for Vitamin C Intake

Ausman, Lynne

doi:10.1111/j.1753-4887.1999.tb06946.x

Cited by 7 publications

(2 citation statements)

References 7 publications

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“…These antioxidants, including glutathione, ubiquinol and uric acid, which are produced during the body's normal metabolism, delay or inhibit cell damage especially by their ability to kill free radicals (Shi et al, 1999). Furthermore, due to the fact that the body cannot manufacture some micronutrients which are considered as antioxidants, they are provided in the diet, such as, vitamin E (α-tocopherol), vitamin C (ascorbic acid) and β-carotene (Ausman, 1999). Therefore, there is a current research on natural polyphenolic antioxidants derived from plants to replace synthetic antioxidants.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Screening, Antioxidant and Antimicrobial Activists of Reamuria vermiculata leaves

Abbassi¹,

Hamdi²,

Triki³

et al. 2022

J. OASIS AGRIC. SUSTAIN. DEV

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The aim of this study is to determine the phytochemical analyses, antioxidant and antimicrobial activities of Reamuria vermiculata leaves extracts. Organic extracts (methanol, hexane, ethyl acetate, petroleum ether) were screened for their biochemical composition as well as antioxidant and antibacterial activities. In fact, Phytochemical screening of Reamuria vermiculata leaves showed the presence of flavonoids, coumarins, saponins, tannins, terpenes, and quinones. Biochemical screening showed that the methanol was the richest extract in phenolic and tanins with 179.68 mg GAE/ g and 56.25 mg CE/g, respectively. The analysis of DPPH radical scavenging activity and ABTS showed an important scavenging with ethyl acetate extract with IC50 of 0.0012mg/mL, and 0.0006mg/mL respectively. As well as, the methanol extract exhibited an antimicrobial property against bacterial strains. Listeria monocytogenes and Salmonella typhimurium were the most sensitive strains with minimum inhibitory concentration values of 0.3125 mg/mL. These results allow us to propose that Reamuria vermiculata is an excellent source for bioactive molecules exhibiting interesting biological capacities.

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Section: Introductionmentioning

confidence: 99%

Phytochemical Screening, Antioxidant and Antimicrobial Activists of Reamuria vermiculata leaves

Abbassi¹,

Hamdi²,

Triki³

et al. 2022

J. OASIS AGRIC. SUSTAIN. DEV

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“…L-ascorbic acid (Vitamin C, L-AA) is an essential micronutrient that functions as a cofactor in various enzymatic reactions [1,2]. It is a known anti-oxidant [3] and is necessary for collagen formation [4], absorption and metabolism of metal ions such as iron and copper [5], and synthesis of neurotransmitters [6].…”

Section: Introductionmentioning

confidence: 99%

L-Ascorbic Acid Inhibits Breast Cancer Growth by Inducing IRE/JNK/CHOP-Related Endoplasmic Reticulum Stress-Mediated p62/SQSTM1 Accumulation in the Nucleus

et al. 2020

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Anticancer effects of L-ascorbic acid (Vitamin C, L-AA) have been reported in various types of cancers. L-AA intake reduces breast cancer recurrence and mortality; however, the role of L-AA in the treatment of breast cancer remains poorly understood. In this study, we investigated the effect and mechanism action of L-AA on breast cancer growth. L-AA inhibited the growth of breast cancer cells by inducing apoptotic cell death at the evaluated treatment concentrations without affecting normal cells. Moreover, L-AA induces autophagosome formation via regulation of mammalian target of rapamycin (mTOR), Beclin1, and autophagy-related genes (ATGs) and increased autophagic flux. Notably, we observed that L-AA increased p62/SQSTM1 (sequestosome 1) protein levels. Accumulation of p62 protein in cancer cells in response to stress has been reported, but its role in cancer regulation remains controversial. Here, we demonstrated that L-AA-induced p62 accumulation is related to L-AA-induced breast cancer growth inhibition. Furthermore, L-AA induced endoplasmic reticulum (ER) stress via the IRE–JNK–CHOP (inositol-requiring endonuclease–c-Jun N-terminal kinase–C/EBP homologous protein) signaling pathways, which increased the nuclear levels of p62/SQSTM1. These findings provide evidence that L-AA-induced ER stress could be crucial for p62 accumulation-dependent cell death, and L-AA can be useful in breast cancer treatment.

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Vitamin Metabolism

Bhagavan

2002

Medical Biochemistry

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Criteria and Recommendations for Vitamin C Intake

Cited by 7 publications

References 7 publications

Phytochemical Screening, Antioxidant and Antimicrobial Activists of Reamuria vermiculata leaves

Phytochemical Screening, Antioxidant and Antimicrobial Activists of Reamuria vermiculata leaves

L-Ascorbic Acid Inhibits Breast Cancer Growth by Inducing IRE/JNK/CHOP-Related Endoplasmic Reticulum Stress-Mediated p62/SQSTM1 Accumulation in the Nucleus

Vitamin Metabolism

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