2022
DOI: 10.1021/acsbiomaterials.2c00194
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Criteria, Challenges, and Opportunities for Acellularized Allogeneic/Xenogeneic Bone Grafts in Bone Repairing

Abstract: As bone grafts become more commonly needed by patients and as donors become scarcer, acellularized bone grafts (ABGs) are becoming more popular for restorative purposes. While autogeneic grafts are reliable as a gold standard, allogeneic and xenogeneic ABGs have been shown to be of particular interest due to the limited availability of autogeneic resources and reduced patient well-being in long-term surgeries. Because of the complete similarity of their structures with native bone, excellent mechanical propert… Show more

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Cited by 34 publications
(15 citation statements)
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“…The mechanism by which allogeneic bone mixed with rhBMP-2 promotes fracture healing may be that allogeneic bone provides a scaffolding structure in the injured vertebrae, which promotes migration and proliferation of osteoblasts in addition to helping to maintain the stability of the fracture site [25] . In contrast, rhBMP-2 mainly promotes the differentiation of stem cells, stimulates the proliferation of cartilage and osteoblasts, accelerates the rate of new bone tissue generation, improves bone matrix protein synthesis, promotes angiogenesis, and provides the nutrients and oxygen needed in the fracture healing process, thus facilitating the process of fracture healing (Fig.…”
Section: Discussionmentioning
confidence: 99%
“…The mechanism by which allogeneic bone mixed with rhBMP-2 promotes fracture healing may be that allogeneic bone provides a scaffolding structure in the injured vertebrae, which promotes migration and proliferation of osteoblasts in addition to helping to maintain the stability of the fracture site [25] . In contrast, rhBMP-2 mainly promotes the differentiation of stem cells, stimulates the proliferation of cartilage and osteoblasts, accelerates the rate of new bone tissue generation, improves bone matrix protein synthesis, promotes angiogenesis, and provides the nutrients and oxygen needed in the fracture healing process, thus facilitating the process of fracture healing (Fig.…”
Section: Discussionmentioning
confidence: 99%
“…Nevertheless, it has not been widely used in clinical practice because of the possibility of latent infection at the donor site and chronic pain [59]. The clinical application of allogeneic bone transplantation has also been severely hindered by limited donor sources, immune rejection, and potential disease transmission [60]. Bone tissue engineering is a multidisciplinary technology that combines osteoblasts, osteoblast-related factors, and scaffold materials, and it provides a new strategy for the regeneration and repair of bone defects [61].…”
Section: Bone Tissue Engineeringmentioning
confidence: 99%
“…6 Noninvasive therapeutic approaches include biophysical stimulation and pulsed electromagnetic field (PEMF) therapy. Surgical intervention is considered one of the most effective solutions for treating bone defects, including the use of bone grafts, 7 the Masquelet technique, 8 the Ilizarov technique, 9 etc. Bone grafts can be classified as natural or synthetic, with autografts, allografts, or xenografts falling into the former category.…”
Section: Introductionmentioning
confidence: 99%