Criteria for Diagnosis of DIC Based on the Analysis of Clinical and Laboratory Findings in 345 DIC Patients Collected by the Research Committee on DIC in Japan

Kobayashi, Norio; Maekawa, Tadashi; Takada, M; Tanaka, Hiroshi; Gonmori, Hidemi

doi:10.1159/000408467

Cited by 234 publications

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“…There was no significant difference in DIC score between survivors and non-survivors. Global coagulation tests, such as platelet counts, FDP, fibrinogen, and PT and DIC score, are important for the diagnosis of DIC and overt-DIC [5,6] but are not sensitive for the early phase of DIC [23]. There was no significant difference in global coagulation tests between DIC patients diagnosed by ISTH and JMHW.…”

Section: Discussionmentioning

confidence: 86%

“…The mortality rates for sepsis (34.2%), hepatic disease (29.2%), cerebral disease (18.3%), and trauma (16.6%) were significantly high (Table I). Among these patients, 76 (4.2%) and 52 (2.9%) fulfilled the DIC diagnostic criteria of JMHW [5] and the overt DIC criteria of ISTH [6], respectively. Seventy-six patients with DIC by JMHW criteria comprised 48 males and 28 females with a mean age (±SEM) of 60.2 ± 6.9 years.…”

Section: Methodsmentioning

confidence: 99%

“…DIC associated with sepsis has recently become a concern for ICU physicians. The Japanese Ministry of Health and Welfare (JMHW) established the diagnostic criteria for DIC in 1987 [5]. The Scientific and Standardization Committee (SSC) of the International Society of Thrombosis and Haemostasis (ISTH) Subcommittee on DIC proposed a new definition for DIC and diagnostic criteria for overt-DIC were proposed at the 18 th Congress of ISTH in 2001 [6].…”

Section: Introductionmentioning

confidence: 99%

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Hemostatic markers and the sepsis‐related organ failure assessment score in patients with disseminated intravascular coagulation in an intensive care unit

et al. 2004

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We investigated the correlation between disseminated intravascular coagulation (DIC) score and hemostatic parameters and sepsis-related organ failure assessment (SOFA) score with clinical outcome of patients with DIC in an intensive care unit (ICU). The SOFA score was markedly elevated in patients with DIC relative to patients without DIC and significantly higher in non-survivors than in survivors. Abnormalities in almost all hemostatic parameters were significant in patients with DIC, but there was no significant difference in almost all hemostatic parameters between survivors and non-survivors. However, plasma antithrombin (AT) levels were significantly lower in non-survivors than in survivors. Soluble fibrin (SF) and tissue type plasminogen activator (tPA)-plasminogen activator inhibitor-I (PAI-I) complex correlated significantly with the SOFA score, whereas AT levels correlated significantly and negatively with the SOFA score. We conclude that the SOFA score is useful for predicting outcome in DIC patients in the ICU, and that hemostatic parameters, especially plasma AT levels, are also useful markers for organ failure and clinical outcome. Am.

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Section: Discussionmentioning

confidence: 86%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hemostatic markers and the sepsis‐related organ failure assessment score in patients with disseminated intravascular coagulation in an intensive care unit

et al. 2004

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“…Several diagnostic criteria for disseminated intravascular coagulation (DIC) have been proposed by Colman et al [1], the Japanese Ministry Health and Welfare (JMHW) [2], and the International Society of Thrombosis and Hemostasis (ISTH) [3], among others. In these diagnostic criteria, global coagulation tests such as the prothrombin time (PT), platelet count, fibrinogen and fibrin and fibrinogen degradation products (FDP) or D-dimer are primarily used for scoring for hemostatic abnormalities.…”

Section: Introductionmentioning

confidence: 99%

Modified non‐overt DIC diagnostic criteria predict the early phase of overt‐DIC

et al. 2010

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of Thrombosis Hemostasis/DIC subcommittee Diagnostic criteria for non-overt disseminated intravascular coagulation (DIC) have been proposed by the International Society of Thrombosis and Hemostasis, but are not useful for the diagnosis of early phase of overt-DIC (pre-DIC). Therefore, in the current study the non-overt DIC diagnostic criteria were modified using the global coagulation tests, the change rate in the global coagulation tests and molecular hemostatic markers to detect the pre-DIC state and were prospectively evaluated in 613 patients with underlying DIC disease. The frequencies of patients with DIC (DIC positive), late onset DIC, and without DIC (DIC absent) were 29.5%, 7.2%, and 63.3%, respectively. The modified non-overt-DIC criteria can correctly predict 43/44 patients (97.7%) who were DIC absent at admission and became DIC positive, within a week (late onset DIC state). The mortality rate was higher in DIC positive compared with pre-DIC (37.6% vs. 22.7%, P < 0.05) or DIC negative (37.6 vs. 13.7%, P < 0.01). It was also significantly higher in pre-DIC compared with DIC negative (P < 0.05). Thus, these modified non-overt DIC diagnostic criteria might therefore be useful for the diagnosis of early-phase DIC. Am. J. Hematol. 85:691-694, 2010. V V C 2010 Wiley-Liss, Inc. IntroductionSeveral diagnostic criteria for disseminated intravascular coagulation (DIC) have been proposed by Colman et al. [1], the Japanese Ministry Health and Welfare (JMHW) [2], and the International Society of Thrombosis and Hemostasis (ISTH) [3], among others. In these diagnostic criteria, global coagulation tests such as the prothrombin time (PT), platelet count, fibrinogen and fibrin and fibrinogen degradation products (FDP) or D-dimer are primarily used for scoring for hemostatic abnormalities. A retrospective study [4] showed that the concordance rate between the JMHW and ISTH diagnostic criteria was 67.4%, and that the ISTH overt-DIC diagnostic criteria were less sensitive for DIC diagnosis than the JMHW criteria. Although the DIC subcommittee of the Scientific Standardized Committee (SSC) in the ISTH emphasized vascular endothelial cell injury as a definition of DIC [3], scoring system based on these three diagnostic criteria do not reflect vascular endothelial cell injury. Recent clinical trials for severe sepsis [5][6][7] showed that the mortality rate of patients with severe sepsis was 35-45% and was even higher in patients with DIC than patients without DIC. The frequency of DIC in patients with severe sepsis was 40.7% according to the KyberSept trial results (antithrombin; AT) [5] and 22.4% in the PROWESS study (recombinant activated protein C; APC) [6]. The patients with severe sepsis have a poor prognosis and the septic patients who also have DIC have an even worse outcome.The treatment efficacy in relation to the JMHW DIC score at the beginning of treatment showed that a greater efficacy was achieved in pre-DIC patients than in DIC patients [8]. The patient prognosis was progressively worse with increasing DIC sc...

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“…At that time, the patient's condition did not satisfy the Japanese Ministry of Health and Welfare (JMHW) criteria for DIC. 8 From PTD 12, the patient received continuous infusion of prostaglandin E1 (500 mg/day) and antithrombin concentrate (1500 units/ day) in addition to continuous infusion of LMWH, but which failed to decrease bilirubin level or ameliorate the right upper quadrant pain, although the liver remained non-palpable clinically and there was no ascites on abdominal ultrasound. On the basis of the modified Seattle Criteria, 9 a definitive diagnosis of SOS was carried out.…”

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confidence: 99%

Recombinant human soluble thrombomodulin for the treatment of hepatic sinusoidal obstructive syndrome post allogeneic hematopoietic SCT

Nakamura

Yoshimitsu

Kawada

et al. 2011

Bone Marrow Transplant

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Criteria for Diagnosis of DIC Based on the Analysis of Clinical and Laboratory Findings in 345 DIC Patients Collected by the Research Committee on DIC in Japan

Cited by 234 publications

References 0 publications

Hemostatic markers and the sepsis‐related organ failure assessment score in patients with disseminated intravascular coagulation in an intensive care unit

Hemostatic markers and the sepsis‐related organ failure assessment score in patients with disseminated intravascular coagulation in an intensive care unit

Modified non‐overt DIC diagnostic criteria predict the early phase of overt‐DIC

Recombinant human soluble thrombomodulin for the treatment of hepatic sinusoidal obstructive syndrome post allogeneic hematopoietic SCT

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