Criteria for Polycystic Ovarian Morphology in Polycystic Ovary Syndrome as a Function of Age

Alsamarai, S.; Adams, Judith; Murphy, Meagan K.; Post, Miriam D.; Hayden, Douglas; Hall, Janet E.; Welt, Corrine K.

doi:10.1210/jc.2009-0839

Cited by 100 publications

(73 citation statements)

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“…It is being thought that severe military conflicts in Africa shorten the expected lifetime for more than 2 years. In general, WHO had calculated that 269 thousand people had died in 1999 due to the effect of wars and that loss of 8.44 million healthy years of life had occurred (2,3). Wars negatively affect the provision of health services.…”

Section: War and Women's Healthmentioning

confidence: 99%

“…Moreover, the wars cause the migration of qualified health employees, and thus the health services hitches. Assessments made indicate that the effect of destruction in the infrastructure of health continues for 5-10 years even after the finalization of conflicts (3). Due to resource requirements in the restructuring investments after war, the share allocated to health has decreased (1).…”

Section: War and Women's Healthmentioning

confidence: 99%

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Polycystic Ovary Morphology (PCOM) in Estradiol Valerate Treated Mouse Model

Amini¹,

Tehranian²,

Movahedin³

et al. 2016

IJWHR

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IntroductionPolycystic ovary syndrome (PCOS) is one of the most common endocrinopathies found among 5%-10% of reproductive age women. It is a common cause of infertility due to anovulatory (1) and hyperandrogenism (2). The name of PCOS is based on ovarian morphological changes in women who suffer from menstrual disturbances and hyperandrogenism symptoms, so polycystic ovary morphology (PCOM) can be a notable feature of PCOS (3). PCOM is revealed by some ovarian morphological abnormalities such as polycystic and enlarged ovaries (4). Although many extra ovarian causes are raised in the pathophysiology of PCOS, ovarian dysfunction plays the most important role in this field (5). Although all women with PCOS are in risk of hormonal and glucose metabolism disturbances, insulin resistance, dyslipidemia, metabolic syndrome, cardiovascular disease, and endometrial hyperplasia (4), it seems that PCOS women with PCOM are in risk of elevated serum DHEA-S levels and also taking a higher daily dose of insulin in comparison to PCOS women without PCOM (6).There are many hypotheses for the etiology of PCOS (7), but the exact initiating event in the pathophysiology of the syndrome is not entirely clear and remains poorly understood. Since the study of pathophysiology or any manipulation for treatment of PCOS/PCOM in human faces some serious logistic and ethical limitations; animal modeling is a good choice to improve the understanding of the abstruse aspects of PCOS (8). Since the 1960s, many animal models such as rodents, sheep and nonhuman primates have been applied for this purpose. Using the mouse models can provide an all-purpose tool for studying and understanding the comprehensive biologic mechanisms of PCOS/PCOM. They have stable genetic backgrounds, shorter reproductive and estrous cycle and generation times, and reasonably priced. Besides, these models have shown same reproductive and metabolic conditions as human PCOS (9). Different procedures have been suggested to produce PCOS model including prenatal or pre-pubertal androgen exposure (10,11), aromatase inhibitor or estradiol administration (11-13), and transgenic models (11). AbstractObjectives: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. Polycystic ovary (PCO) is a criterion for PCOS. Several animal models of polycystic ovary morphology (PCOM) are developed in order to study PCOS aspects. The present study aimed to develop a polycystic ovarian model in mice. Materials and Methods: Thirty-four young adult female mice were divided equally into estradiol valerate (EV) treated and control groups. Mice in experimental group (n = 18) received a single dose injection of EV (IM, 4 mg/kg). Weight and fertility rate of all mice were recorded. Morphology of ovarian follicles was assessed too. Chi-square and independent t test were used for comparison between groups. P value less than 0.05 was considered as significant level. Results: After 60 days, the weight of EV-treated mice was significantly lower than control (P ...

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Section: War and Women's Healthmentioning

confidence: 99%

Section: War and Women's Healthmentioning

confidence: 99%

Polycystic Ovary Morphology (PCOM) in Estradiol Valerate Treated Mouse Model

Amini¹,

Tehranian²,

Movahedin³

et al. 2016

IJWHR

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“…Los ciclos menstruales tienden a regularizarse 27 y el hiperandrogenismo se reduce 28 . Tal como en mujeres sanas, disminuye el número de folículos y el volumen ovárico 29 . En mujeres con SOP los cambios relacionados con la edad dificultan la identificación de pacientes no diagnosticadas en la edad reproductiva temprana, lo que podría afectar la incidencia observada de SOP 30 .…”

Section: Discussionunclassified

Clasificación de los fenotipos de síndrome de ovario poliquístico de acuerdo a los criterios de Rotterdam: ¿una condición estática o variable?

et al. 2014

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“…There are some data that this ultrasonographic finding is frequent in young women and decreases with age (46)(47)(48). In adults, this sonographic finding may be present in 10% to 20% of healthy women with regular menstrual cycles and without clinical hyperandrogenism (49,50).…”

Section: Polycystic Ovarian Morphologymentioning

confidence: 97%

A rational approach to the diagnosis of polycystic ovarian syndrome during adolescence

Merino

Codner

Cassorla

2011

Arq Bras Endocrinol Metab

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SUMMARYPolycystic ovarian syndrome (PCOS) is a lifelong disorder characterized by hyperandrogenism and ovulatory dysfunction, with a wide spectrum of clinical symptoms and signs. Three different sets of diagnostic criteria have been established in order to define this disease in adult women, but there is controversy regarding the use of these criteria in adolescence. During puberty, the adult criteria for ovulatory dysfunction does not seem applicable, because an irregular menstrual pattern and a decreased ovulatory rate is a physiologic event during this period of life. Also, a higher prevalence of polycystic ovarian morphology (PCOM) may be observed during this period, so PCOM is not a useful criterion to define PCOS in young women. These findings suggest that a key factor to diagnose to PCOS during adolescence is hyperandrogenism. In addition, since PCOM is not clearly associated with hyperandrogenism during this period of life, the term "polycystic ovarian syndrome" during adolescence creates confusion and may be misleading. Arq Bras Endocrinol Metab. 2011;55(8):590-8 Keywords Hyperandrogenism; hirsutism; polycystic ovarian syndrome; adolescence; diagnosis; puberty; polycystic ovarian morphology; menstrual irregularities; anti-Müllerian hormone SUMáRio A síndrome dos ovários policísticos (SOP) é uma desordem que afeta pacientes por toda a vida e é caracterizada por hiperandrogenismo e disfunção ovariana, com um amplo leque de sintomas e sinais clínicos. Três diferentes conjuntos de critérios diagnósticos foram estabelecidos para definir essa doença em mulheres adultas, mas existem controvérsias relacionadas ao uso desses critérios na adolescência. Durante a puberdade, o critério de disfunção ovariana usado em adultos não parece aplicável, porque um padrão menstrual irregular e uma menor taxa de ovulação são eventos fisiológicos nesse período da vida. Além disso, uma maior prevalência de morfologia ovariana policística (MOP) pode ser observada nesse período, de forma que a MOP não é um critério útil para se definir a SOP em mulheres jovens. Esses achados sugerem que o hiperandrogenismo é um fator-chave para o diagnóstico da SOP na adolescência. Além disso, como a MOP não está claramente associada com o hiperandrogenismo durante esse período da vida, o termo "síndrome dos ovários policísticos" durante a adolescência cria confusão e pode ser errôneo. Arq Bras Endocrinol Metab. 2011;55(8):590-8 Descritores

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Criteria for Polycystic Ovarian Morphology in Polycystic Ovary Syndrome as a Function of Age

Abstract: Ovarian volume and follicle number decrease with age in women with PCOS and controls necessitating age-based criteria to define polycystic ovarian morphology. It is possible to use these criteria to distinguish PCOS in women over age 40 yr.

Cited by 100 publications

References 50 publications

Polycystic Ovary Morphology (PCOM) in Estradiol Valerate Treated Mouse Model

Polycystic Ovary Morphology (PCOM) in Estradiol Valerate Treated Mouse Model

Clasificación de los fenotipos de síndrome de ovario poliquístico de acuerdo a los criterios de Rotterdam: ¿una condición estática o variable?

A rational approach to the diagnosis of polycystic ovarian syndrome during adolescence

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