Criteria for the Integration of Epidemic Processes of Hiv Infection and Tuberculosis

Шугаева, С. Н.; Савилов, Е. Д.

doi:10.21292/2075-1230-2019-97-5-43-48

Cited by 6 publications

(2 citation statements)

References 5 publications

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“…An immunochromatographic test was used to detect a fraction of the mycobacterial protein MPT64, which is isolated from MBT cells during cultivation on liquid and solid nutrient media [ 25 ]. SD BIOLINE TB Ag MPT64 Rapid tests (Standard Diagnostics, Korea) were used for identification.…”

Section: Methodsmentioning

confidence: 99%

“…TB incidence is unequally distributed across the country, and the Siberian Federal District is characterized by a high prevalence of TB infection, morbidity, and mortality [ 25 ]. The TB/HIV prevalence in 2019 in Siberia was the highest among Russian Federal Districts (46.4/100,000) and 2.3 higher than the national average ( Figure 1 ) [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

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Epidemiology and Drug Resistance Patterns of Mycobacterium tuberculosis in High-Burden Area in Western Siberia, Russia

Kostyukova¹,

Pasechnik

Mokrousov

2023

Microorganisms

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Russia is a high-burden area for multidrug-resistant tuberculosis (MDR-TB). Here, we studied the epidemiological situation and drug resistance patterns of Mycobacterium tuberculosis in the Omsk region in Western Siberia. M. tuberculosis isolates (n = 851) were recovered from newly diagnosed TB patients in 2021. The isolates were tested by bacteriological and molecular methods, and long-term epidemiological data were analyzed. The TB incidence dec, this is not variablereased from 93.9 in 2012 to 48.1 in 2021, per 100,000 population, but the primary MDR-TB rate increased from 19.2% to 26.4%. The destructive forms of tuberculosis accounted for 37.8% of all cases, while 35.5% of patients were smear-positive. Of all isolates tested, 55.2% were culture-positive, of which 94.5% were further tested for phenotypic drug resistance and associated mutations. More than half (53.4%) of isolates were drug-resistant, 13.9% were monoresistant and 67.9% were MDR. Among MDR isolates, 40.4% were pre-XDR, and 19.2% were XDR. The spectrum of drug resistance included second-line drugs (new-generation fluoroquinolones, linezolid), which significantly increase the risk of an adverse outcome in patients. In conclusion, our results highlight the critical importance of monitoring drug resistance in circulating M. tuberculosis strains emerging due to ineffective treatment and active transmission.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Epidemiology and Drug Resistance Patterns of Mycobacterium tuberculosis in High-Burden Area in Western Siberia, Russia

Kostyukova¹,

Pasechnik

Mokrousov

2023

Microorganisms

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Periodization of the History of Epidemiology and the Formation of an Interdisciplinary Stage in the Development of This Preventive Discipline

Brico,

Savilov

2024

Annals RAMS

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The article discusses the process of formation and further development of epidemiology at a new post-classical stage in the formation of science. In the first period of the formation of science (XVII century), its activities were carried out only through the intra-disciplinary development of knowledge, and its last stage (post-classical period falling on the present) is based on the development of interdisciplinary ties. This approach allows us to identify previously seemingly distant and purely specific subject areas and discover new research subjects that cannot be discovered and accordingly used in internal disciplinary analysis. In the post-classical period of science, the formation of modern epidemiology occurs, in the development of which three main periods are distinguished: the pre-bacteriological, bacteriological and modern stage, which determines the population approach when studying a diverse pathology. The transformations taking place in epidemiology contribute to the convergence of this science with clinical medicine, which should bring this preventive medicine to a higher level of development. Epidemiology in the post-classical period of science can be expected to move to a new stage of its development, which will be based on an interdisciplinary generalization of infectious and non-infectious pathology.

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Formation of Cross-Disciplinary Interaction of Epidemiology and Pathological Physiology during Post-Nonclassical Development of Science

2022

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In the submitted message the process of historical formation of epidemiology and the prospect of development of this preventive discipline in its cross-disciplinary interaction with a pathophysiology on new, post-nonclassical, a stage of formation of science is considered. These two fundamental medical sciences are engaged in any diseases (pathological states) irrespective of their origin and have identical approaches to their study which in the most generalized view can be reduced to identification of the causes, mechanisms of development and outcomes of pathological states at the level of generalizations. In both scientific disciplines also an object of researches a disease of the person (sick organism) is identical. Fundamental differences take place only for the main subject of studying these sciences which pathological processes for a pathophysiology and population morbidity, including its consequences, for epidemiology are. But and these categories in many respects are an essence one and too, but only at various levels of the organization of live. Therefore, the nature of transformations of both scientific disciplines in philosophical and methodological sense completely keep within a framework of modern transformations of science during formation of its post-nonclassical stage. It in turn assists formation of the next (cross-disciplinary) period in epidemiology which continues and develops basic provisions of its third stage defining population approach when studying various pathology. Thus, in the period of post-nonclassical science there is a process of cross-disciplinary formation of epidemiology that brings her to higher level of development and generalizations.

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Criteria for the Integration of Epidemic Processes of Hiv Infection and Tuberculosis

Cited by 6 publications

References 5 publications

Epidemiology and Drug Resistance Patterns of Mycobacterium tuberculosis in High-Burden Area in Western Siberia, Russia

Epidemiology and Drug Resistance Patterns of Mycobacterium tuberculosis in High-Burden Area in Western Siberia, Russia

Periodization of the History of Epidemiology and the Formation of an Interdisciplinary Stage in the Development of This Preventive Discipline

Formation of Cross-Disciplinary Interaction of Epidemiology and Pathological Physiology during Post-Nonclassical Development of Science

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