Criteria for the use of mixed solvents in gas—liquid chromatography

Laub, R. J.; Purnell, J. H.

doi:10.1016/s0021-9673(00)99943-6

Cited by 253 publications

(59 citation statements)

References 5 publications

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“…For easier monitoring of peak displacement, individual peak heights were chosen for each type of compound. Window diagram optimization [72] of the separation is shown in Figure 7. The diagram shows the resolution of the worst separated pair of compounds (Rs,min) as a function of midpoint pressure.…”

Section: Creating a Data Basementioning

confidence: 99%

Application of a flow-tunable, serially coupled gas chromatographic capillary column system for the analysis of complex mixtures

Garay¹

2000

Chromatographia

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SummaryA capillary column gas chromatographic system employing two serially coupled fused-silica columns and a simple coupling element is described. The system is operated in flow-tunable mode (flow-tunable tandem system). The very fact of continuous tuning over a large polarity (selectivity) range, ultimately determined by the two constituent columns, offers several possibilities in the analysis of complex mixtures. In this paper two applications are discussed in detail: optimization of peak separation and peak identification. For these applications it is feasible to use, retention data collected from experiments on the tandem system, and empirical formulas. A relatively simple theoretical mathematical model valid for the flow-tunable tandem system, however, furnishes an easy way of calculating retention data on the system from data collected from the individual single columns, thus, creating a new possibility for optimization and peak identification. Optimization and peak identification processes using the empirical and theoretical models are both demonstrated by analysis of solvent mixtures.

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Section: Creating a Data Basementioning

confidence: 99%

Application of a flow-tunable, serially coupled gas chromatographic capillary column system for the analysis of complex mixtures

Garay¹

2000

Chromatographia

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“…Thus, the separation problem must also involve the first (OV-1) column. The Window Diagram procedure of Purnell and Laub [16,17] was utilized by the computer program to obtain the fractional lengths of columns necessary for the separation of the key components of the mixture from the interfering compounds. In this procedure the separation factor for the most difficult to separate pair (whose identity may change as the phase mixture is varied) is plotted versus the mole fraction of the phases used for the separation.…”

Section: Solutionmentioning

confidence: 99%

A Strategy for the Simplification and Solution of Complex Chromatographic Analysis Problems Utilizing Two-Dimensional Mapping of Retention Indexes Followed by Computer Modeling of Heart Cuts from Serially Coupled Columns Containing Different Stationary Phases

Annino

Villalobos

1999

J. High Resol. Chromatogr.

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The analysis of four components in a mixture containing many possible interferents is simplified by heart‐cutting serially connected columns containing stationary phases of widely different polarities. The design of the proper lengths of the two columns and timing the heart‐cuts is accomplished with the aid of a computer simulation of the problem. The computer program calculates the proper lengths of column to produce the shortest analysis time and also outputs the predicted chromatograms from both columns. The chromatogram from the first column is used to construct the timing gates for the heart‐cuts and the chromatogram from the second or analytical column is used to set integration gates for the selected compounds of interest.

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“…Indeed, the differences are substantial enough that mixtures of OV-1 with SP-2100 can be used for window-diagram optimization [21], e.g., of halocarbon solutes [22]. Thus, there is little question that retentions with crosslinked and bonded polymeric phases warrant further and comprehensive study, since at the very least the matter bears directly on analytical GC as well as supercritical fluid chromatographic separations.…”

Section: Solutementioning

confidence: 99%

Specific retention volumes and retention indices of selected olefin solutes with OV‐101 poly (dimethylsiloxane) stationary phase

Laub

1987

J. High Resol. Chromatogr.

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Criteria for the use of mixed solvents in gas—liquid chromatography

Cited by 253 publications

References 5 publications

Application of a flow-tunable, serially coupled gas chromatographic capillary column system for the analysis of complex mixtures

Application of a flow-tunable, serially coupled gas chromatographic capillary column system for the analysis of complex mixtures

A Strategy for the Simplification and Solution of Complex Chromatographic Analysis Problems Utilizing Two-Dimensional Mapping of Retention Indexes Followed by Computer Modeling of Heart Cuts from Serially Coupled Columns Containing Different Stationary Phases

Specific retention volumes and retention indices of selected olefin solutes with OV‐101 poly (dimethylsiloxane) stationary phase

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