Study Design: A multicenter, single-masked study of patients with patellofemoral pain syndrome (PFPS) using a repeated-measures design. Objective: To compare 3 different methods of patellar taping for individuals with PFPS. Background: Patellar taping is commonly used as a treatment for PFPS. It is commonly thought that taping works by medially realigning the patella. However, comparisons have been rarely made with other methods of taping which attempt to realign the patella in different directions. Methods and Measures: Seventy-one patients with PFPS (39 men, 32 women; average age ± SD, 34 ± 10 years) from 3 different treatment centers were tested. Each patient performed 4 single step-downs from a standard 8-inch (20.3-cm) platform, initially with the patella untaped and then with the patella taped in a medial, neutral, and lateral direction. Pain was recorded on a standard 11-point numerical pain rating scale. The sequence of taping was randomly allocated and patients were masked to the method used. The methods of taping were compared using repeated-measures generalized linear model analysis. Results: All methods of taping significantly decreased pain when compared to the untaped condition (PϽ.0001). Neutral-and lateral-glide techniques produced a significantly greater degree of pain relief (PϽ.0001) than the medial-glide technique. Conclusion: In this study, patellar taping produced an immediate decrease in pain in patients with PFPS, irrespective of how taping was applied. These data raise questions as to the mechanism of action of patellar taping. Furthermore, these results suggest that it is unlikely that taping works by altering patellar position. J Orthop Sports Phys Ther 2003;33:437-448. Key Words: knee, lower extremity, patella, tape P atellofemoral pain syndrome (PFPS) is a condition frequently seen by physical therapists. It is characterized by diffuse pain over the anterior aspect of the knee and is usually aggravated by activities that increase patellofemoral joint compressive forces, such as ascending or descending stairs, squatting, and prolonged sitting. 30 It is the most prevalent disorder involving the knee, 2,18,25 the second most common musculoskeletal complaint present- 26 Despite this frequency of presentation, the etiology of PFPS remains unclear. 6,30 Many authors have proposed that the primary cause of PFPS is lateral tracking of the patella. 12,16 Support for this theory comes from radiological studies designed to identify differences in patellofemoral joint alignment between asymptomatic and pathological patellae. 1,24,29 However, studies have shown PFPS to be present with no radiographic sign of patellar lateralization 21,36 and others have reported radiographic evidence of maltracking in healthy, asymptomatic subjects. 20,32 Based largely upon the theory of patellar maltracking, McConnell 26 has devised a system of treatment for PFPS by taping the patella in a medial direction. She proposes that the taping works primarily by causing a mechanical medial realignment of the ...