Critical Ages and Stages of Puberty in the Accumulation of Spinal and Femoral Bone Mass: The Validity of Bone Mass Measurements

Baroncelli, Gi; Saggese, Giuseppe

doi:10.1159/000063441

Cited by 43 publications

(2 citation statements)

References 27 publications

(65 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Whilst growth and virilisation are the most visible observations of puberty, the period of puberty is further defined by other significant physical, emotional and psychological changes that are primarily due to the increase in systemic sex steroid concentrations. Physically, puberty is a critical period during which humans achieve optimal bone mass [13] and there is accumulating evidence that in adults with childhood-onset chronic disease, abnormalities of bone health seem to develop during the peri-pubertal years [14,15] and may be related to hypogonadism [16]. Late sexual maturation in boys may also have an impact on psychological well-being and has been shown to be associated with altered behaviour and poorer educational attainment [17,18].…”

Section: Discussionmentioning

confidence: 99%

Effect of Testosterone Therapy for Delayed Growth and Puberty in Boys with Inflammatory Bowel Disease

et al. 2010

View full text Add to dashboard Cite

Background: Pubertal delay and growth retardation are common in children with inflammatory bowel disease (IBD). Aims: To assess pubertal status and growth in a group of boys with IBD undergoing testosterone therapy for pubertal induction. Methods: Retrospective study of height, weight and pubertal status in 8 boys with IBD before and after testosterone therapy. Height velocity (HV) over the 6 months before each assessment was converted to standard deviation score. Markers of disease activity and concomitant medication were recorded. Response was based on an advance in pubertal status and a greater than 50% increase in HV. Results: Eight boys with IBD, median age 14.8 years, had pubertal induction using either monthly injections of 50 mg Sustanon or daily 2.5/5 mg Andropatch. Seven boys showed an advance of pubertal status. Six boys had a greater than 50% increase in HV; median HV at T0 was 1.6 cm/year (0, 5) compared with 6.9 cm/year (1, 11.7) at T6 (p = 0.005). C-reactive protein during testosterone therapy had a significant association with HV at T6 (r = –0.786; p = 0.021). Conclusion: In most cases, testosterone therapy in boys with IBD and delayed growth and puberty is associated with an advance in pubertal status and an improvement in growth.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of Testosterone Therapy for Delayed Growth and Puberty in Boys with Inflammatory Bowel Disease

et al. 2010

View full text Add to dashboard Cite

show abstract

“…When corrected the difference in BMD is statistically significant in age groups 16 through 18 years (5). Correction of lumbar BMD for bone volume by the use of mathematical formulations reduces the effect of bone size but vBMD remains dependent on age and bone size during growth except that femoral neck vBMD is independent of age prior to puberty (5,(18)(19)(20)(21)(22). In 345 Turkish healthy children (2-28 yr) it has been shown that volumetric BMD reduces the effects of age on BMD but it is still dependent on age (unpublished data, Go¨ks¸en et al, Ege University Faculty of Medicine, Izmir).…”

Section: Discussionmentioning

confidence: 99%

Bone mineral density in pediatric and adolescent renal transplant patients: How to evaluate

Gökşen¹,

Darcan²,

Kara

et al. 2005

Pediatric Transplantation

View full text Add to dashboard Cite

Reduced bone mass is a common complication of renal transplantation in adults but only few data are present for pediatric transplant patients. Bone mineral status of pediatric renal transplant patients ages ranging from 7.5 to 17.6 years (mean age 14.9 +/- 2.3) who were at least 6 months postrenal transplantation was examined. Bone mineral density (BMD) of lumbar vertebrea and femoral neck was determined by dual energy X-ray absorptiometry (DEXA) and z-scores according to age, puberty, height and bone age were compared to sex and ethnic specific reference data. z-scores were calculated for both areal and volumetric bone density. BMD L1-4 z-scores were more than 2 SD below the mean according to chronological age in 12 patients (63%), pubertal status in six patients (31.5%), bone age in five patients (26.3%) and height in five patients (26.3%). The BMD femoral neck z-scores were more than 2 SD below the mean according to age in 10 patients (55.5%), puberty in five patients (27.7%), bone age in three (16.6%) patients and height in five (26.3%) patients. Correction of the vertebrae and femoral neck for bone size yielded osteoporotic values for seven patients (36.8%) for lumbar BMD and for four patients (22%) for femoral neck BMD. The use of aBMD in growth-retarded children has some restrictions in determining z-scores. Deficits in spinal bone density still persisted after correcting for height, puberty, bone age and volume. In renal transplant patients who have short stature it is reasonable to give values corrected for height, puberty, bone age and bone size and interpret each of these values for each patient.

show abstract

Ontogeny of Skeletal Maturation in the Juvenile Rat

Horton

Bariteau

Loomis

et al. 2008

The Anatomical Record

View full text Add to dashboard Cite

Systemic regulation of the cellular processes that produce endochondral elongation and endochondral mineralization during postnatal skeletal maturation are not completely understood. In particular, a mechanism coupling the decline of cellular activity in the bone microenvironment to the onset of sexual maturity remains elusive. The purpose of this study was to empirically integrate the dynamic progression of bone mineral accrual and endochondral elongation as a function of animal age in growing male and female Sprague-Dawley rats. We used serial dual-energy X-ray absorptiometry (DXA) and radiography to study the temporal progression of bone growth and mineral accrual from weaning to adulthood. We observed that skeletal maturation proceeds in a pattern adequately described by the Gompertz function. During this period of growth, we found that serum markers of osteoblastic bone formation declined with age, while osteoclastic bone resorption activity remained unchanged. We also report a slight lag in the age at inflection in the rate of bone mineral accrual relative to the rate of tibial elongation and that both endochondral processes eventually come to asymptotic equilibrium by approximately 20 weeks of age. In addition, we studied tibial growth plate histomorphometry at select time points through 1 year of age. We report that, despite the histologic persistence of physeal cartilage, very little proliferative or elongative activity was measured in this tissue beyond 20 weeks of age. Taken together, these data provide insight to the temporal coordination of postnatal endochondral growth processes.

show abstract

Critical Ages and Stages of Puberty in the Accumulation of Spinal and Femoral Bone Mass: The Validity of Bone Mass Measurements

Cited by 43 publications

References 27 publications

Effect of Testosterone Therapy for Delayed Growth and Puberty in Boys with Inflammatory Bowel Disease

Effect of Testosterone Therapy for Delayed Growth and Puberty in Boys with Inflammatory Bowel Disease

Bone mineral density in pediatric and adolescent renal transplant patients: How to evaluate

Ontogeny of Skeletal Maturation in the Juvenile Rat

Contact Info

Product

Resources

About