2016
DOI: 10.3390/medicines3040029
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Critical Analysis on Characterization, Systemic Effect, and Therapeutic Potential of Beta-Sitosterol: A Plant-Derived Orphan Phytosterol

Abstract: Beta-sitosterol (BS) is a phytosterol, widely distributed throughout the plant kingdom and known to be involved in the stabilization of cell membranes. To compile the sources, physical and chemical properties, spectral and chromatographic analytical methods, synthesis, systemic effects, pharmacokinetics, therapeutic potentials, toxicity, drug delivery and finally, to suggest future research with BS, classical as well as on-line literature were studied. Classical literature includes classical books on ethnomedi… Show more

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Cited by 117 publications
(76 citation statements)
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“…β -Sitosterol, campesterol, and stigmasterol are among the main biosynthetic final products in the phytosterol pathway. Stigmasterol, known as one of the main phytosterols, has been the object of previous studies because of its significance as an anti-inflammatory, antioxidant, and antitumor agent [ 48 ]. In this study, the unripe galbuli from location 1 contained a higher percentage of stigmasterol than the other samples.…”
Section: Discussionmentioning
confidence: 99%
“…β -Sitosterol, campesterol, and stigmasterol are among the main biosynthetic final products in the phytosterol pathway. Stigmasterol, known as one of the main phytosterols, has been the object of previous studies because of its significance as an anti-inflammatory, antioxidant, and antitumor agent [ 48 ]. In this study, the unripe galbuli from location 1 contained a higher percentage of stigmasterol than the other samples.…”
Section: Discussionmentioning
confidence: 99%
“…Betasitosterol Fig. 4, a phytosterol reported in all the ingredients of SEH exhibits hyperlipidemic, cholesterol lowering, anticancer and antidiabetic properties 15 . Similarly, Lupeol Fig.…”
Section: Discussionmentioning
confidence: 99%
“…Hexadecanoic acid, methyl ester possesses antioxidant, hypocholesterolemic, nematicide, and pesticide properties [94] while n-Hexadecanoic acid has the antioxidant and anticancer capabilities [94]. Moreover, β-Sitosterol acetate is responsible for antioxidant, antipyretic, anti-Inflammatory, anti-arthritic, anti-cancer, anti-diabetic, and antimicrobial activities [95] whereas α-Tocospiro A has antituberculasis activity [96,97]. In addition, vitamin E has been reported to have anti-cardiovascular, anti-dementia, anticonvulsant, antioxidant, neuroprotector activities, and improving neurological dysfunction [98,99].…”
Section: Compoundsmentioning
confidence: 99%