Critical appraisal of questionnaires to assess functional impairment in individuals with mild cognitive impairment

Kaur, Navaldeep; Belchior, Patrícia; Gélinas, Isabelle; Bier, Nathalie

doi:10.1017/s104161021600017x

Cited by 33 publications

(34 citation statements)

References 43 publications

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“…We performed correlation analyses between complexity of BOLD signals in these brain regions with significant MSE differences and cognitive function scores (MMSE, FAQ, and CDR). These three clinical measurements provide quantitative assessments of cognitive function and are widely used ( Ciesielska et al, 2016 ; Kaur et al, 2016 ; Kim et al, 2017 ). Higher scores of MMSE indicate higher aptitude of cognition; low functional performance is related to higher FAQ scores and the presence of dementia is indicated by higher CDR scores.…”

Section: Discussionmentioning

confidence: 99%

Dynamic Complexity of Spontaneous BOLD Activity in Alzheimer’s Disease and Mild Cognitive Impairment Using Multiscale Entropy Analysis

et al. 2018

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Alzheimer’s disease (AD) is characterized by progressive deterioration of brain function among elderly people. Studies revealed aberrant correlations in spontaneous blood oxygen level-dependent (BOLD) signals in resting-state functional magnetic resonance imaging (rs-fMRI) over a wide range of temporal scales. However, the study of the temporal dynamics of BOLD signals in subjects with AD and mild cognitive impairment (MCI) remains largely unexplored. Multiscale entropy (MSE) analysis is a method for estimating the complexity of finite time series over multiple time scales. In this research, we applied MSE analysis to investigate the abnormal complexity of BOLD signals using the rs-fMRI data from the Alzheimer’s disease neuroimaging initiative (ADNI) database. There were 30 normal controls (NCs), 33 early MCI (EMCI), 32 late MCI (LMCI), and 29 AD patients. Following preprocessing of the BOLD signals, whole-brain MSE maps across six time scales were generated using the Complexity Toolbox. One-way analysis of variance (ANOVA) analysis on the MSE maps of four groups revealed significant differences in the thalamus, insula, lingual gyrus and inferior occipital gyrus, superior frontal gyrus and olfactory cortex, supramarginal gyrus, superior temporal gyrus, and middle temporal gyrus on multiple time scales. Compared with the NC group, MCI and AD patients had significant reductions in the complexity of BOLD signals and AD patients demonstrated lower complexity than that of the MCI subjects. Additionally, the complexity of BOLD signals from the regions of interest (ROIs) was found to be significantly associated with cognitive decline in patient groups on multiple time scales. Consequently, the complexity or MSE of BOLD signals may provide an imaging biomarker of cognitive impairments in MCI and AD.

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Section: Discussionmentioning

confidence: 99%

Dynamic Complexity of Spontaneous BOLD Activity in Alzheimer’s Disease and Mild Cognitive Impairment Using Multiscale Entropy Analysis

et al. 2018

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“…For example, widely used tests such as the Mini–Mental State Examination (MMSE) [8] and the Alzheimer's Disease Assessment Scale–cognitive subscale (ADAS-Cog) [9] have been shown to be inappropriate for use in the design and evaluation of clinical trials targeted at MCI and mild AD [10] , [11] , [12] , [13] . As to the measurement of everyday functioning, recent reviews pointed out that most commonly used questionnaires are only of limited use to detect the early functional decline [14] , [15] .…”

Section: Introductionmentioning

confidence: 99%

A novel cognitive‐functional composite measure to detect changes in early Alzheimer's disease: Test–retest reliability and feasibility

Jutten

Harrison

Kjoe

et al. 2017

Alz & Dem Diag Ass & Dis Mo

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Introduction To improve the detection of changes in Alzheimer's disease (AD), we designed the cognitive-functional composite (CFC). As a first validation step, we investigated its test–retest reliability and feasibility of use. Methods We performed a test–retest study with 2–3 weeks between assessments, including patients with mild cognitive impairment (MCI) or mild AD dementia and cognitively healthy participants. We calculated intraclass correlation coefficients (ICCs) type absolute agreement for all CFC measures and compared baseline and retest scores using paired-samples t -tests. We evaluated feasibility by interviewing participants. Results Forty-three patients (40% female, mean age = 69.9) and 30 controls (50% female, mean age = 65) were included. Subtest intraclass correlation coefficients ranged from .70 to .96. We found negligible improvements after retesting on only two subtests. Overall, patients perceived the administration of the CFC as feasible. Discussion The CFC is a stable and feasible measure in MCI and mild AD dementia, and thereby meets important quality metrics for clinically meaningful outcome measures.

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“…Este fue determinado según el cuestionario de Pfeiffer (positivo para deterioro cognitivo con resultados de 4 puntos o más) que evalúa 10 preguntas sobre memoria y otras funciones mentales superiores [19,20] . Esta prueba tiene una sensibilidad del 83% y especificidad del 84% para evaluación de trastornos neurocognitivos [21] .…”

Section: Variables De Estudiounclassified

Relación entre el riesgo de caídas y deterioro cognitivo en adultos mayores atendidos en el Centro Médico Naval “Cirujano Mayor Santiago Távara” 2010-2015*

2019

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Objetivo: Determinar la relación entre el riesgo de caídas y deterioro cognitivo en adultos mayores del Centro Médico Naval “Cirujano Mayor Santiago Távara” 2010-2015. Materiales y métodos: Fue un estudio observacional, analítico, retrospectivo, que consistió en el análisis secundario de una base de datos. Se evaluó el riesgo de caídas mediante los resultados de la prueba de alcance funcional (AF), mientras que para determinar el deterioro cognitivo se utilizó el cuestionario de Pfeiffer. Adicionalmente, se estudiaron factores socio-demográficos como la edad, sexo, nivel educativo; y clínicos como la presencia de comorbilidades, polifarmacia o antecedentes de caídas. Resultados: La muestra estuvo conformada por 1786 adultos mayores. El 45,1% tenían entre 71 y 80 años, de sexo masculino (58,9%), con nivel educativo técnico/ superior (70,9%), tenían 2 o más comorbilidades (48,9%). Se encontró asociación estadística (p<0,05) entre AF alterado y la edad, el nivel educativo, la presencia de comorbilidades, y el deterioro cognitivo. Al realizar el modelo multivariado, se encontró que el deterioro cognitivo se asoció al riesgo de caídas con un PR ajustado de 3,05 (IC 95%: 2,45-3,79). Conclusión: Se encontró que el deterioro cognitivo estuvo asociado a un riesgo tres veces mayor de caídas en adultos mayores del Centro Médico Naval “Cirujano Mayor Santiago Távara” durante los años 2010-2015.

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Critical appraisal of questionnaires to assess functional impairment in individuals with mild cognitive impairment

Cited by 33 publications

References 43 publications

Dynamic Complexity of Spontaneous BOLD Activity in Alzheimer’s Disease and Mild Cognitive Impairment Using Multiscale Entropy Analysis

Dynamic Complexity of Spontaneous BOLD Activity in Alzheimer’s Disease and Mild Cognitive Impairment Using Multiscale Entropy Analysis

A novel cognitive‐functional composite measure to detect changes in early Alzheimer's disease: Test–retest reliability and feasibility

Relación entre el riesgo de caídas y deterioro cognitivo en adultos mayores atendidos en el Centro Médico Naval “Cirujano Mayor Santiago Távara” 2010-2015*

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