Critical aspects of sample handling for direct nanoparticle analysis and analytical challenges using asymmetric field flow fractionation in a multi-detector approach

Ulrich, Andrea; Losert, Sabrina; Bendixen, Nina; Al-Kattan, Ahmed; Hagendorfer, Harald; Nowack, Bernd; Adlhart, Christian; Ebert, Jürgen; Lattuada, Marco; Hungerbühler, Karin

doi:10.1039/c2ja30024a

Cited by 99 publications

(71 citation statements)

References 52 publications

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“…Use of nonionic surfactant (Triton X-100) having relatively lower value of zeta potential led to a nearcomplete separation from the void peak, allowing particle approach closer to the channel wall (Ulrich et al 2012). Meanwhile, the attractive van der Waals force could be increased with reduction in the distance between particle and channel surface, resulting in a lower sample recovery (Ulrich et al 2012).…”

Section: Optimization Of Sdfff For Analysis Of Fe 3 O 4 Mnpsmentioning

confidence: 98%

Effect of size of Fe3O4 magnetic nanoparticles on electrochemical performance of screen printed electrode using sedimentation field-flow fractionation

et al. 2014

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Section: Optimization Of Sdfff For Analysis Of Fe 3 O 4 Mnpsmentioning

confidence: 98%

Effect of size of Fe3O4 magnetic nanoparticles on electrochemical performance of screen printed electrode using sedimentation field-flow fractionation

et al. 2014

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“…(84) There are various techniques and approaches which allow direct analysis of NPs by getting not only information on chemical composition but also size simultaneously. (85) The particle size, which includes size distribution and aggregation state, is arguably one of the most important properties to quantify biodistribution of NPs and when conducting toxicity tests. (86) In relation to ICPMS, other approaches for solution/diluted suspensions show potential to be applied:…”

Section: Future Challenges Of Inductively Coupled Plasma Mass Spectromentioning

confidence: 99%

“…The chosen setting of the plasma power is of great importance for achieving a complete ionization of particles up to the micrometer size. (1,85) Beyond method sensitivity limitations, many current techniques have been shown to be well suited to characterize polydisperse systems that contain aggregates. (86) sp-ICPMS is an emerging analytical technique that has the potential of addressing some of the major challenges faced by investigators when analyzing for particle size within toxicity tests.…”

Section: Single-particle (Sp) Mode Icpmsmentioning

confidence: 99%

“…Although the stability of sterically stabilized NPs is typically less affected by the mentioned factors, agglomeration can still occur. (85) However, while sp-ICPMS offers some selectivity, a major disadvantage to sp-ICPMS at present is that it is not able to distinguish between particles with the different elemental composition. Owing to the current limitations of sp-ICPMS, where only one isotope can be monitored at a time, it was not possible to differentiate between these two particle types.…”

Section: Single-particle (Sp) Mode Icpmsmentioning

confidence: 99%

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Inductively Coupled Plasma‐Mass Spectrometry in Biodistribution Studies of (Engineered) Nanoparticles

Krystek

Braakhuis

Park

et al. 2013

Encyclopedia of Analytical Chemistry

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The biodistribution of engineered inorganic nanomaterials with size characteristics of one, two, or three dimensions smaller than 100 nm is a fast‐growing analytical and toxicological research field. This review gives a detailed overview about biodistribution studies with gold (Au), silver (Ag), and titanium dioxide (TiO 2 ) nanoparticles (NPs). Exposure to NPs is possible via inhalation, injection, ingestion, and skin contact. The distribution of NPs in the body is affected by their chemical/elemental composition, size and size distribution, shape, coatings, surface properties, and their stability under the selected circumstances. The evaluation of the presence of NPs to determine their tissue distribution is not easy. NP presence can be identified by electron microscopy (EM) but this is a time‐ and labor‐consuming technique. So, instead of determining the presence of the NPs themselves, distribution studies can use elemental analysis by inductively coupled plasma mass spectrometry (ICPMS) as indication for the tissue distribution of NPs. In the field of analytical research, the suitable application of ICPMS is crucial and discussed in detail. Other relevant analytical techniques, the obtained results as well as the evaluations, are presented too.

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“…Uncontrolled particle-membrane interactions can lead to changes on the NPs elution time [163] NPs in coffee creamer [55] ], tomato soup [29] and also for TiO 2 NPs in sunscreens [52].…”

Section: Field-flow Fractionationmentioning

confidence: 99%

Detection, characterization and quantification of inorganic engineered nanomaterials: A review of techniques and methodological approaches for the analysis of complex samples

Laborda

Bolea

Cepriá

et al. 2016

Analytica Chimica Acta

331

170

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The increasing demand of analytical information related to inorganic engineered nanomaterials requires the adaptation of existing techniques and methods, or the development of new ones.The challenge for the analytical sciences has been to consider the nanoparticles as a new sort of analytes, involving both chemical (composition, mass and number concentration) and physical information (e.g. size, shape, aggregation). Moreover, information about the species derived from the nanoparticles themselves and their transformations must also be supplied. Whereas techniques commonly used for nanoparticle characterization, such as light scattering techniques, show serious limitations when applied to complex samples, other well-established techniques, like electron microscopy and atomic spectrometry, can provide useful information in most cases. Furthermore, separation techniques, including flow field flow fractionation, capillary electrophoresis and hydrodynamic chromatography, are moving to the nano domain, mostly hyphenated to inductively coupled plasma mass spectrometry as element specific detector.Emerging techniques based on the detection of single nanoparticles by using ICP-MS, but also coulometry, are in their way to gain a position. Chemical sensors selective to nanoparticles are in their early stages, but they are very promising considering their portability and simplicity.Although the field is in continuous evolution, at this moment it is moving from proofs-of-2 concept in simple matrices to methods dealing with matrices of higher complexity and relevant analyte concentrations. To achieve this goal, sample preparation methods are essential to manage such complex situations. Apart from size fractionation methods, matrix digestion, extraction and concentration methods capable of preserving the nature of the nanoparticles are being developed. This review presents and discusses the state-of-the-art analytical techniques and sample preparation methods suitable for dealing with complex samples. Single-and multimethod approaches applied to solve the nanometrological challenges posed by a variety of stakeholders are also presented.

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Critical aspects of sample handling for direct nanoparticle analysis and analytical challenges using asymmetric field flow fractionation in a multi-detector approach

Cited by 99 publications

References 52 publications

Effect of size of Fe3O4 magnetic nanoparticles on electrochemical performance of screen printed electrode using sedimentation field-flow fractionation

Effect of size of Fe3O4 magnetic nanoparticles on electrochemical performance of screen printed electrode using sedimentation field-flow fractionation

Inductively Coupled Plasma‐Mass Spectrometry in Biodistribution Studies of (Engineered) Nanoparticles

Detection, characterization and quantification of inorganic engineered nanomaterials: A review of techniques and methodological approaches for the analysis of complex samples

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