1996
DOI: 10.1002/(sici)1097-4598(199604)19:4<516::aid-mus11>3.0.co;2-n
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Critical care myopathy: An electrophysiological and histological study

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Cited by 58 publications
(28 citation statements)
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“…10,11 Several animal and clinical studies have attributed the occurrence of ACM to the use of high doses of corticosteroids in a short period of time. [13][14][15][16][17][18][19][22][23][24] Nava et al, 22 in their rat model, showed that i.v. MP 80 mg/kg/ day for 5 days could induce severe limb and respiratory muscle wasting and predominantly type IIb muscle atrophy.…”
Section: Discussionmentioning
confidence: 99%
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“…10,11 Several animal and clinical studies have attributed the occurrence of ACM to the use of high doses of corticosteroids in a short period of time. [13][14][15][16][17][18][19][22][23][24] Nava et al, 22 in their rat model, showed that i.v. MP 80 mg/kg/ day for 5 days could induce severe limb and respiratory muscle wasting and predominantly type IIb muscle atrophy.…”
Section: Discussionmentioning
confidence: 99%
“…In human clinical studies, high doses of steroids (up to 3 g/day) are often administered for patients in status asthmaticus or rejection after organ transplantation. 18 ACM has been reported with increased frequency, [13][14][15][16][17][18][19] in patients who have been treated with high-dose corticosteroids since its first description by MacFalane and Rosenthal 24 in 1977. ACM differs from the slowly progressive steroid myopathy described by Cushing 25 in 1932.…”
Section: Discussionmentioning
confidence: 99%
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“…Later, a similar acute myopathy was noted to follow organ transplantation [22][23][24][25][26][27] and to occur in association with many other critical illness states in children as well as adults. [28][29][30][31][32][33][34][35] Terminology was highly variable initially, but eventually the name critical illness myopathy (CIM) was accepted. 36 Also, during the same period, it was noted that rare ICU patients developed prolonged neuromuscular junction (NMJ) blockade after receiving paralytic drugs in high doses or for prolonged periods in association with persisting drug metabolites and organ failure.…”
Section: Historymentioning
confidence: 99%
“…3 It is usually associated with the use of intravenous corticosteroids (CS) and non depolarizing neuromuscular blocking agents. 4 , 5 It has been reported rarely in transplant recipients 3,5,6 and only one case, formally documented with muscle biopsy, has been reported in children. 7 No pediatric cases have been reported after cardiac surgery or organ transplantation.…”
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confidence: 99%