Coal mines are composed of multiple complex rock strata with different mechanical characteristics and energy accumulation and release performances. This implies uneven energy distribution in the coal-rock combination system (CRCS). To explore the effect of the included angle between the loading direction and the coal-rock contact surface on the mechanical properties, crack propagation mode, and energy evolution characteristics of the CRCS, the uniaxial compression tests were carried out on the CRCS samples with zero and 30° inclination angles. The obtained mechanical properties and energy dissipation trends of the tested samples were similar to those of the pure (raw) coal and rock ones but strongly depended on the inclination angles. The impact energy index of the CRCS samples was smaller than those of the pure coal and pure rock samples, and its impact tendency was less pronounced. The deformation and failure of the CRCS samples occurred in the coal part, the rock part inhibiting the development and deformation of the coal. According to the deformation and failure characteristics of the CRCS, the coal support far away from the contact surface should be strengthened in engineering practice to avoid the rock mass failure caused by the expansion and evolution of cracks in the coal part. At a 30° inclination angle, the CRCS sample was tensioned at the coal-rock contact surface, and the original cracks and pores were gradually compacted under the stress component perpendicular to the contact surface. With an increase in the inclination angle, the difference between the total energy accumulated before the peak and the released energy after the peak was reduced, and the difference between the total energy accumulated before the peak and the dissipated energy increased gradually. CRCS samples with different inclinations exhibited three damage stages: initial damage, stable damage growth, and rapid damage growth. The results obtained are considered instrumental in rockburst preventing, monitoring, and early warning under different stress environments.