Critical evaluation of the use of dogs in biomedical research and testing in Europe

Hasiwa, Nina; Bailey, Jarrod; Clausing, Peter; Daneshian, Mardas; Eileraas, Marianne; Farkas, Sándor; Gyertyán, István; Hubrecht, Robert; Kobel, Werner; Krummenacher, Goran; Leist, Marcel; Lohi, Hannes; Miklósi, Ádám; Ohl, Frauke; Olejniczak, Klaus; Schmitt, Georg; Sinnett-Smith, Patrick; Smith, David; Wagner, Kristina; Yager, James D.; Zurlo, Joanne; Hartung, Thomas

doi:10.14573/altex.2011.4.326

Cited by 57 publications

(50 citation statements)

References 59 publications

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“…It can be deduced from the results of this research that MMGTs can be regarded as an HBC model; likewise, similar studies evidently have described this issue (Andrade et al, 2010;Hasiwa et al, 2011;Queiroga et al, 2011). Ethical issues are the point that should be considered in modeling studies.…”

Section: Discussionsupporting

confidence: 74%

Overexpression of HER-2/neu in Malignant Mammary Tumors: Translation of Clinicopathological Features from Dog to Human

Muhammadnejad¹,

Keyhani²,

Mortazavi³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Section: Discussionsupporting

confidence: 74%

Overexpression of HER-2/neu in Malignant Mammary Tumors: Translation of Clinicopathological Features from Dog to Human

Muhammadnejad¹,

Keyhani²,

Mortazavi³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…Dogs are often used in safety studies as a second species and biomarkers of bone metabolism are validated and are well-established for dogs. However, there are societal concerns regarding the use of dogs in biomedical research and the ethical framework related to their welfare [151] consistently restricts the use of dogs in preclinical testing.…”

Section: Dogmentioning

confidence: 99%

The rational use of animal models in the evaluation of novel bone regenerative therapies

Perić¹,

Dumić-Čule²,

Grčević³

et al. 2015

Bone

130

116

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“…However, the major disadvantage is the high costs required for their maintenance. Additionally, the domestication of dogs has led to their decreasing use for research (27). …”

Section: Advantages and Disadvantages Of These Model Systemsmentioning

confidence: 99%

Animal models for the study of primary and secondary hypertension in humans

et al. 2016

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Hypertension is a significant cause of morbidity and mortality worldwide. It is defined as systolic and diastolic blood pressures (SBP/DBP) >140 and 90 mmHg, respectively. Individuals with an SBP between 120 and 139, or DBP between 80 and 89 mmHg, are said to exhibit pre-hypertension. Hypertension can have primary or secondary causes. Primary or essential hypertension is a multifactorial disease caused by interacting environmental and polygenic factors. Secondary causes are renovascular hypertension, renal disease, endocrine disorders and other medical conditions. The aim of the present review article was to examine the different animal models that have been generated for studying the molecular and physiological mechanisms underlying hypertension. Their advantages, disadvantages and limitations will be discussed.

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Critical evaluation of the use of dogs in biomedical research and testing in Europe

Abstract: Summary Dogs are sometimes referred to as "man's best friend" and with the increase in urbanization and

Cited by 57 publications

References 59 publications

Overexpression of HER-2/neu in Malignant Mammary Tumors: Translation of Clinicopathological Features from Dog to Human

Overexpression of HER-2/neu in Malignant Mammary Tumors: Translation of Clinicopathological Features from Dog to Human

The rational use of animal models in the evaluation of novel bone regenerative therapies

Animal models for the study of primary and secondary hypertension in humans

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