The breeding blanket is one of the fundamental components of a nuclear fusion reactor and is responsible for the fuel production, generating tritium through neutronic capture reaction between lithium and neutrons. Lithium is a liquid PbLi alloy and the helium formed as reaction by-product can coalesce into bubbles, generating a two-phase mixture with a high-density ratio (ηρ∼O5). These bubbles can accumulate and stagnate within the blanket channels with potentially harmful consequences. In this work, the interIsoFoam solver of OpenFOAM v2012 is used to simulate bubble motion for a two-phase mixture representative of the He-PbLi system to test its potential for future developments in the field of fusion. In a first phase, several traditional benchmarks were carried out, both 2D and 3D, and considering the two variants of the VOF method implemented in the solver, isoAdvector and plicRDF. Subsequently, He bubbles of different diameters rising in liquid PbLi (ηρ=1.2×105) were analysed to investigate different regimes. For a Eötvös number (Eo) greater than 10, it was possible to recreate the axisymmetric, skirted, oscillatory regimes and the peripheral and central breakup regimes. For Eo < 10, non-physical deformations of the interface are observed, probably generated by spurious velocities that have a greater impact on the solution for very small bubbles and rising velocities.