Critical flicker frequency test for diagnosing minimal hepatic encephalopathy in patients with cirrhosis

Coşkun, Banu Demet Özel; Özen, Mustafa

doi:10.5152/tjg.2017.16618

Cited by 11 publications

(9 citation statements)

References 13 publications

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“…However, some researchers believe that CFF should be used as an adjunct to the PHES test because of its low sensitivity for detecting MHE. They found that CFF had a diagnostic accuracy of 70.6%, specificity of 82%, sensitivity of 39% for detecting MHE (Ozel Coskun and Ozen 2017 ). However, for the threshold of CFF, the researchers had different choices.…”

Section: Diagnosis Of Mhe: Cognitive Evaluationmentioning

confidence: 99%

Cognition-tracking-based strategies for diagnosis and treatment of minimal hepatic encephalopathy

et al. 2020

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Minimal hepatic encephalopathy (MHE), which shows mild cognitive impairment, is a subtle complication of cirrhosis that has been shown to affect daily functioning and quality of life. However, until 2014, relevant guidelines do not give much attention to the diagnosis and treatment of MHE, resulting in patients being ignored and denied the benefits of treatment. In this review, we summarize recent cognition-based research about (1) alteration of nerve cells, including astrocytes, microglial cells and neurons, in mild cognitive impairment in MHE; (2) comparison of methods in detecting cognitive impairment in MHE; and (3) comparison of methods for therapy of cognitive impairment in MHE. We hope to provide information about diagnosis and treatment of cognitive impairment in patients with MHE.

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Section: Diagnosis Of Mhe: Cognitive Evaluationmentioning

confidence: 99%

Cognition-tracking-based strategies for diagnosis and treatment of minimal hepatic encephalopathy

et al. 2020

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“…In the CFF, patients are shown a light flicker that progressively decreases in frequency 88 . They must identify the frequency at which the light flickers 88 .…”

Section: Recent Advances In the Diagnosis Of Hepatic Encephalopathymentioning

confidence: 99%

“…In the CFF, patients are shown a light flicker that progressively decreases in frequency 88 . They must identify the frequency at which the light flickers 88 . CFF can be used as a measure of cortical function and the diagnosis of HE 88 .…”

Section: Recent Advances In the Diagnosis Of Hepatic Encephalopathymentioning

confidence: 99%

“…They must identify the frequency at which the light flickers 88 . CFF can be used as a measure of cortical function and the diagnosis of HE 88 . Studies show that with a cut-off value of <39 Hz, CFF has a sensitivity of 39%, specificity of 82%, and diagnostic accuracy of 70.6% for MHE 82 , 88 .…”

Section: Recent Advances In the Diagnosis Of Hepatic Encephalopathymentioning

confidence: 99%

“…CFF can be used as a measure of cortical function and the diagnosis of HE 88 . Studies show that with a cut-off value of <39 Hz, CFF has a sensitivity of 39%, specificity of 82%, and diagnostic accuracy of 70.6% for MHE 82 , 88 . CFF is an important and simple tool for diagnosis and should be combined with the model for end stage liver disease (MELD) score for better diagnosis 89 .…”

Section: Recent Advances In the Diagnosis Of Hepatic Encephalopathymentioning

confidence: 99%

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Recent advances in hepatic encephalopathy

2017

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Hepatic encephalopathy describes the array of neurological alterations that occur during acute liver failure or chronic liver injury. While key players in the pathogenesis of hepatic encephalopathy, such as increases in brain ammonia, alterations in neurosteroid levels, and neuroinflammation, have been identified, there is still a paucity in our knowledge of the precise pathogenic mechanism. This review gives a brief overview of our understanding of the pathogenesis of hepatic encephalopathy and then summarizes the significant recent advances made in clinical and basic research contributing to our understanding, diagnosis, and possible treatment of hepatic encephalopathy. A literature search using the PubMed database was conducted in May 2017 using “hepatic encephalopathy” as a keyword, and selected manuscripts were limited to those research articles published since May 2014. While the authors acknowledge that many significant advances have been made in the understanding of hepatic encephalopathy prior to May 2014, we have limited the scope of this review to the previous three years only.

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Psychometric methods for diagnosing and monitoring minimal hepatic encephalopathy —current validation level and practical use

et al. 2022

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Critical flicker frequency test for diagnosing minimal hepatic encephalopathy in patients with cirrhosis

Cited by 11 publications

References 13 publications

Cognition-tracking-based strategies for diagnosis and treatment of minimal hepatic encephalopathy

Cognition-tracking-based strategies for diagnosis and treatment of minimal hepatic encephalopathy

Recent advances in hepatic encephalopathy

Psychometric methods for diagnosing and monitoring minimal hepatic encephalopathy —current validation level and practical use

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