In order to stably operate the equipment inside the tokamak, which is loaded with a heat flux of several MW/m2 under the one-side heating condition, it is necessary to thoroughly prepare for various thermal engineering limits that may occur under the high heat flux load condition. In this study, we have experimentally explored critical heat flux (CHF) and onset of flow instability (OFI), which are considered potential threats in a DEMO fusion power plant. Specifically, the effect of system parameters on CHF was investigated. The results indicate that with an increase in subcooling and mass flux, the CHF increased, as it induced a faster bubble condensation near the CHF. As the system pressure increased, the CHF also increased. This is because the bubble size reduction effect was dominant in the pressure range of 1–10 bar. Most of the existing CHF correlations could evaluate the CHF with reasonable accuracy of within 25%; especially, the Boscary CHF correlation yielded the highest accuracy with an average error of 12%. Similar to CHF, OFI, which is a measure of the sudden fluctuations in the system pressure caused by a large amount of vapor generated due to the high heat flux, tended to increase as the subcooling, mass flow rate, and system pressure increased. Most of the existing OFI correlations yielded large error rates (more than 135%) as these correlations were primarily developed for micro-channels. Therefore, in this study, a new OFI correlation was developed using a Python code, in combination with an artificial intelligence (AI) regression method. The developed correlation can be used in the cooling system design of tokamaks, which involve a high-heat load condition on one-side of the reactor.