Critical illness in patients with hematologic malignancy: a population-based cohort study

Ferreyro, Bruno L.; Scales, Damon C.; Wunsch, Hannah; Cheung, Matthew C.; Gupta, Vikas; Saskin, Refik; Thyagu, Santhosh; Munshi, Laveena

doi:10.1007/s00134-021-06502-2

Cited by 52 publications

(31 citation statements)

References 42 publications

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“…Storms et al [ 35 ] reported the highest rates for ICU admission among older age groups and among persons with underlying medical conditions. Ferreyro et al [ 36 ] reported that cardiovascular disease, chronic obstructive pulmonary disease, and baseline laboratory abnormalities as well as myeloid leukemia, aggressive non-Hodgkin lymphoma, and acute lymphoblastic leukemia were associated with increased risk for ICU admission. In multivariable analysis performed by Vijenthira et al [ 37 ] researchers reported acute leukemia, curative intent chemotherapy, and laboratory-related factors as risk factors for ICU admission among patients with hematologic malignancy.…”

Section: Discussionmentioning

confidence: 99%

Predictors of Vancomycin-Resistant Enterococcus spp. Intestinal Carriage among High-Risk Patients in University Hospitals in Serbia

et al. 2022

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The predictors of intestinal carriage of vancomycin-resistant Enterococcus spp. (VRE) among high-risk patients in the counties of the Southeast Europe Region are insufficiently investigated, yet they could be of key importance in infection control. The aim of the study was to identify risk factors associated with fecal VRE colonization among high-risk inpatients in university hospitals in Serbia. The study comprised 268 inpatients from three university hospitals. Data on patient demographics and clinical characteristics, length of hospital stay, therapy, and procedures were obtained from medical records. Chi-squared tests and univariate and multivariate logistic regressions were performed. Compared to the hemodialysis departments, stay in the geriatric departments, ICUs, and haemato-oncology departments increased the risk for VRE colonization 7.6, 5.4, and 5.5 times, respectively. Compared to inpatients who were hospitalized 48 h before stool sampling for VRE isolation, inpatients hospitalized 3–7, 8–15, and longer than 16 days before sampling had 5.0-, 4.7-, and 6.6-fold higher risk for VRE colonization, respectively. The use of cephalosporins and fluoroquinolones increased the risk for VRE colonization by 2.2 and 1.9 times, respectively. The age ≥ 65 years increased the risk for VRE colonization 2.3 times. In comparison to the University Clinical Centre of Serbia, the hospital stays at Zemun and Zvezdara University Medical Centres were identified as a protector factors. The obtained results could be valuable in predicting the fecal VRE colonization status at patient admission and consequent implementation of infection control measures targeting at-risk inpatients where VRE screening is not routinely performed.

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Section: Discussionmentioning

confidence: 99%

Predictors of Vancomycin-Resistant Enterococcus spp. Intestinal Carriage among High-Risk Patients in University Hospitals in Serbia

et al. 2022

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“…Das individuelle Risiko von Krebspatienten, im Laufe ihrer Erkrankung einer Aufnahme auf eine Intensivstation zu erleiden, wurde beispielhaft an einer kanadischen Kohortenstudie an 87 965 Patienten mit einer hämatologischen malignen Erkrankung untersucht 8 .…”

Section: Prävalenz Und Patientenkollektivunclassified

Intensivmedizinische Betreuung hämatologischer und onkologischer Patienten

Böll¹,

Kochanek²,

Eichenauer³

et al. 2022

Dtsch Med Wochenschr

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Obwohl sich die Prognose hämatologischer und onkologischer Patienten in den letzten Jahrzehnten drastisch verbessert hat, ist ihre Sterblichkeit auf der Intensivstation im Vergleich zu Nicht-Krebspatienten immer noch hoch. Daher ist das interdisziplinäre Management von entscheidender Bedeutung, um zu ermitteln, welche Patienten von einer Verlegung auf die Intensivstation profitieren, und um die Behandlung zu optimieren. Dieser Beitrag gibt einen Überblick über den aktuellen Stand der Intensivtherapie dieser gefährdeten und oft komplexen Patienten. ABKÜR ZUNGEN CAR-T-Zellen chimärer Antigen-Rezeptor-T-Zellen CRS cytokine release syndrome ICU Intensivstation IMC Intermediate Care Station irAEs immune-related adverse events

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“…Acute respiratory failure, especially the Acute Respiratory Distress Syndrome (ARDS) following lung infection contributed to a large proportion of admissions of hematological patients to the Intensive Care Units (ICU). 1 , 2 As a result of the therapeutic progress in critical care medicine and as a result of the advancements in immunological therapies and chemotherapies, the prognosis of these patients has been improved over the years. 3 However, ARDS in hematological patients still has relatively high mortality and responded poorly to various treatments when compared to immunocompetent hosts.…”

Section: Introductionmentioning

confidence: 99%

Lung Microbiota Signature and Corticosteroid Responses in Pneumonia-Associated Acute Respiratory Distress Syndrome in Hematological Patients

Shen¹,

Hu²,

Lv³

et al. 2022

JIR

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Objective In this study, we aim to classify hematological patients with the pneumonia-associated acute respiratory syndrome (ARDS) into different groups that were characterized by distinct early responsiveness to corticosteroids, describe the microbiota signatures of the non-responders and responders, and compare the prognosis of the two groups. Methods Hematological patients with ARDS were included and treated with mechanical ventilation and corticosteroid. According to the early improvement to the corticosteroid therapy, patients were classified as non-responders and responders. The lung microbiota signatures and the outcomes of the non-responders and responders were compared. Results Fifty patients were included in this study. Twenty-eight patients were classed as non-responders and 22 as responders. Compared to the non-responders, responders had higher serum levels of IL-6, IL-8, TNF-α and CRP, their lung microbiota was with lower alpha diversity and enriched with virus species. The responders had an overall higher ventilator free days than the non-responders [4 (0–6) vs 6 (0–10), p=0.034], for survivors the difference was more significant [5 (3–6) vs 8 (3–10), p=0.012]. Survival analysis showed that there was no difference in survival rate between the two groups over time (Log-rank p=0.073). When non-responders were stratified into subgroups of patients with infection or co-infection, those non-responders with co-infection had significantly lower survival rate than other patients (Log-rank p= 0.028). Conclusion For hematological patients with pneumonia-associated ARDS, the responders of corticosteroids had higher ventilator free days at day 28 than the non-responders. The microbiota signatures were distinct in the two groups. The non-responders with coinfections had the lowest survival rate when compared to the non-responders with no coinfections and the responders.

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Critical illness in patients with hematologic malignancy: a population-based cohort study

Cited by 52 publications

References 42 publications

Predictors of Vancomycin-Resistant Enterococcus spp. Intestinal Carriage among High-Risk Patients in University Hospitals in Serbia

Predictors of Vancomycin-Resistant Enterococcus spp. Intestinal Carriage among High-Risk Patients in University Hospitals in Serbia

Intensivmedizinische Betreuung hämatologischer und onkologischer Patienten

Lung Microbiota Signature and Corticosteroid Responses in Pneumonia-Associated Acute Respiratory Distress Syndrome in Hematological Patients

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