Abstract. The paper deals with the specific cases of the changing of stability of slow integral manifold of singularly perturbed systems of ODE via the dynamic model of nerve conduction. It is shown that the proper choice of the additional parameters of the system allows us to construct the slow integral manifold with multiple change of its stability.Keywords: singular perturbations, canards, delaying of the loss of stability, critical phenomena, Hindmarsh-Rose model. Citation: Shchepakina EA. Three scenarios for changing of stability in the dynamic model of nerve conduction.