Critical Point in Self-Organized Tissue Growth

Aguilar-Hidalgo, Daniel; Wartlick, Ortrud; González‐Gaitán, Marcos; Friedrich, Benjamin M.; Jülicher, Frank

doi:10.1103/physrevlett.120.198102

Cited by 35 publications

(31 citation statements)

References 51 publications

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“…diffusion and degradation constants) (Werner et al, 2016). How scalable systems might achieve the necessary adjustment of reaction rates to system size remains an important problem not only in regeneration, but also in development (Aguilar-Hidalgo et al, 2018;Ben-Zvi et al, 2011;Werner et al, 2015). Here, the uncoupling of pattern scaling from tissue growth during the early stages of planarian regeneration promises a uniquely specific model system to elucidate the underlying mechanisms.…”

Section: Size and Shape Controlmentioning

confidence: 99%

Model systems for regeneration: planarians

et al. 2019

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Planarians are a group of flatworms. Some planarian species have remarkable regenerative abilities, which involve abundant pluripotent adult stem cells. This makes these worms a powerful model system for understanding the molecular and evolutionary underpinnings of regeneration. By providing a succinct overview of planarian taxonomy, anatomy, available tools and the molecular orchestration of regeneration, this Primer aims to showcase both the unique assets and the questions that can be addressed with this model system.

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Section: Size and Shape Controlmentioning

confidence: 99%

Model systems for regeneration: planarians

et al. 2019

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“…2 A (36). The physical origin of the resulting pattern is here similar to active fluid instabilities (15, 17, 37–40): If stochastic local changes in morphogen concentration result in an increase in cell volume fraction, fluid must be pumped inside cells. This causes local elastic deformations in the tissue which generate large-scale extracellular fluid flows from regions of low to high morphogen concentration, resulting in a positive feedback loop of morphogen enrichment (Fig.…”

Section: Resultsmentioning

confidence: 91%

Theory of mechanochemical patterning in biphasic biological tissues

Recho

Hallou

Hannezo

2019

Proc. Natl. Acad. Sci. U.S.A.

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The formation of self-organized patterns is key to the morphogenesis of multicellular organisms, although a comprehensive theory of biological pattern formation is still lacking. Here, we propose a minimal model combining tissue mechanics with morphogen turnover and transport to explore routes to patterning. Our active description couples morphogen reaction and diffusion, which impact cell differentiation and tissue mechanics, to a two-phase poroelastic rheology, where one tissue phase consists of a poroelastic cell network and the other one of a permeating extracellular fluid, which provides a feedback by actively transporting morphogens. While this model encompasses previous theories approximating tissues to inert monophasic media, such as Turing’s reaction–diffusion model, it overcomes some of their key limitations permitting pattern formation via any two-species biochemical kinetics due to mechanically induced cross-diffusion flows. Moreover, we describe a qualitatively different advection-driven Keller–Segel instability which allows for the formation of patterns with a single morphogen and whose fundamental mode pattern robustly scales with tissue size. We discuss the potential relevance of these findings for tissue morphogenesis.

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“…First, thick proveins are refined into narrow veins during pupal development, allowing for the possibility to globally alter the final resting place of veins (23). Second, the number, size and shapes of intervein epidermal cells might vary, and after expansion, separate neighboring veins by different distances (38-41). These effects could be exacerbated in the proximal wing during hinge contraction, which occurs over an extended period of time (42-44).…”

Section: Discussionmentioning

confidence: 99%

Global Constraints within the Developmental Program of theDrosophilaWing

Alba¹,

Carthew

et al. 2020

Preprint

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Organismal phenotypes emerge from a complex set of genotypic interactions. While technological advances in sequencing provide a quantitative description of an organism's genotype, characterization of an organism's physical phenotype lags far behind. Here, we relate genotype to the complex and multi-dimensional phenotype of an anatomical structure using the Drosophila wing as a model system. We develop a mathematical approach that enables a robust description of biologically salient phenotypic variation. Analysing natural phenotypic variation, and variation generated by weak perturbations in genetic and environmental conditions during development, we observe a highly constrained set of wing phenotypes. In a striking example of dimensionality reduction, the nature of varieties produced by the Drosophila developmental program is constrained to a single integrated mode of variation in the wing. Our strategy demonstrates the emergent simplicity manifest in the genotype-to-phenotype map in the Drosophila wing and may represent a general approach for interrogating a variety of genotype-phenotype relationships.

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Critical Point in Self-Organized Tissue Growth

Cited by 35 publications

References 51 publications

Model systems for regeneration: planarians

Model systems for regeneration: planarians

Theory of mechanochemical patterning in biphasic biological tissues

Global Constraints within the Developmental Program of theDrosophilaWing

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