Critical review of analytical methods for the determination of flame retardants in human matrices

Hajeb, Parvaneh; Castaño, Argelia; Cequier, Enrique; López, Marta Esteban; Antuña, Ana González; Haug, Line Småstuen; Henríquez-Hernández, Luis Alberto; Melymuk, Lisa; Luzardo, Octavio P.; Thomsen, Cathrine; Vorkamp, Katrin

doi:10.1016/j.aca.2021.338828

Cited by 11 publications

(7 citation statements)

References 172 publications

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“…Śmiełowska and Zabiegała (2020a) reviewed current solutions used for sample preparation and respective future trends for PBDE analysis. Hajeb et al (2021) performed a critical review of analytical methods for the determination of PBDEs and a number of other BFRs in human matrices. Co-extracted lipids and other interfering compounds can be removed in several ways, such as gel permeation chromatography (GPC), aluminium-oxide chromatography and multilayer silica chromatography.…”

Section: Methods Of Analysismentioning

confidence: 99%

Update of the risk assessment of polybrominated diphenyl ethers (PBDEs) in food

Schrenk,

Bignami,

Bodin

et al. 2024

EFS2

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The European Commission asked EFSA to update its 2011 risk assessment on polybrominated diphenyl ethers (PBDEs) in food, focusing on 10 congeners: BDE‐28, ‐47, ‐49, ‐99, ‐100, ‐138, ‐153, ‐154, ‐183 and ‑209. The CONTAM Panel concluded that the neurodevelopmental effects on behaviour and reproductive/developmental effects are the critical effects in rodent studies. For four congeners (BDE‐47, ‐99, ‐153, ‐209) the Panel derived Reference Points, i.e. benchmark doses and corresponding lower 95% confidence limits (BMDLs), for endpoint‐specific benchmark responses. Since repeated exposure to PBDEs results in accumulation of these chemicals in the body, the Panel estimated the body burden at the BMDL in rodents, and the chronic intake that would lead to the same body burden in humans. For the remaining six congeners no studies were available to identify Reference Points. The Panel concluded that there is scientific basis for inclusion of all 10 congeners in a common assessment group and performed a combined risk assessment. The Panel concluded that the combined margin of exposure (MOET) approach was the most appropriate risk metric and applied a tiered approach to the risk characterisation. Over 84,000 analytical results for the 10 congeners in food were used to estimate the exposure across dietary surveys and age groups of the European population. The most important contributors to the chronic dietary Lower Bound exposure to PBDEs were meat and meat products and fish and seafood. Taking into account the uncertainties affecting the assessment, the Panel concluded that it is likely that current dietary exposure to PBDEs in the European population raises a health concern.

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Section: Methods Of Analysismentioning

confidence: 99%

Update of the risk assessment of polybrominated diphenyl ethers (PBDEs) in food

Schrenk,

Bignami,

Bodin

et al. 2024

EFS2

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show abstract

“…It is impossible to select a single biological matrix that encompasses the global population, as well as all target compounds. Due to the lipophilic nature of PBDEs and HBCDDs, they are best evaluated through matrices such as blood serum or breast/maternal milk . Breast milk has a high lipid content and can be collected noninvasively, making it a reliable and accessible matrix for assessing body burdens of PBDEs and HBCDDs, as well as many other POPs.…”

Section: Methodsmentioning

confidence: 99%

“…Due to the lipophilic nature of PBDEs and HBCDDs, they are best evaluated through matrices such as blood serum or breast/ maternal milk. 72 Breast milk has a high lipid content and can be collected noninvasively, making it a reliable and accessible matrix for assessing body burdens of PBDEs and HBCDDs, as well as many other POPs. The Stockholm Convention, in cooperation with the World Health Organization, has identified human milk as a core matrix of its Global Monitoring Plan and supported with routine quantification in pooled milk samples.…”

Section: Rationalization Of Study Matrixmentioning

confidence: 99%

Has Regulatory Action Reduced Human Exposure to Flame Retardants?

van der Schyff,

Kalina,

Abballe

et al. 2023

Environ. Sci. Technol.

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“…The extensive application and widespread production of TBBPA have given rise to neurotoxicity, immunotoxicity, endocrine disruption, carcinogenic effects, and developmental and reproductive toxicity. 11 Hence, there is an urgent need to detect BPs in environmental samples to evaluate the environmental pollution status and apply corresponding governance measures.…”

Section: Introductionmentioning

confidence: 99%

“…However, these substitutes are not necessarily safer than BPA, exhibiting an estrogenic effect equal to or even stronger than BPA. ,, Tetrabromobisphenol A (TBBPA) is extensively utilized as a flame retardant. The extensive application and widespread production of TBBPA have given rise to neurotoxicity, immunotoxicity, endocrine disruption, carcinogenic effects, and developmental and reproductive toxicity . Hence, there is an urgent need to detect BPs in environmental samples to evaluate the environmental pollution status and apply corresponding governance measures.…”

Section: Introductionmentioning

confidence: 99%

Hydroxy-Containing Covalent Organic Framework Combined with Nickel Ferrite as a Platform for the Recognition and Capture of Bisphenols

Shi

et al. 2023

ACS Appl. Mater. Interfaces

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A hydroxy-containing covalent organic framework (COF) was successfully obtained via a simple nitrogen-purge synthetic procedure for the first time. The COF favored a serrated AA-stacking arrangement, which enhanced the stability compared with common AA or AB arrangements. To validate the potential of the COF in environmental applications, we decorated the COF onto NiFe2O4 and used the NiFe2O4@COF nanocomposite for magnetic solid-phase extraction of trace bisphenols (BPs). The parameters affecting extraction efficiencies were systematically optimized. Under the optimum extraction conditions, calibration plots showed good linearity (5.0–1.0 × 103 ng mL–1) for six BPs, and limits of detection varied from 0.14 to 0.73 ng mL–1. Molecular polarity indexes and molecular dynamics simulations revealed why the COF could efficiently recognize and capture BPs. An adsorption mechanism related to the interaction between BP clusters and the COF was discovered. Ecotoxicological assessment of BPs further unraveled the significance of the developed method for the timely tracking of the concentration, distribution, and migration of BPs in environmental media.

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Critical review of analytical methods for the determination of flame retardants in human matrices

Cited by 11 publications

References 172 publications

Update of the risk assessment of polybrominated diphenyl ethers (PBDEs) in food

Update of the risk assessment of polybrominated diphenyl ethers (PBDEs) in food

Has Regulatory Action Reduced Human Exposure to Flame Retardants?

Hydroxy-Containing Covalent Organic Framework Combined with Nickel Ferrite as a Platform for the Recognition and Capture of Bisphenols

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