Critical review of electronic nose and tongue instruments prospects in pharmaceutical analysis

Wasilewski, T.; Migoń, Dorian; Gębicki, Jacek; Kamysz, Wojciech

doi:10.1016/j.aca.2019.05.024

Cited by 117 publications

(66 citation statements)

References 127 publications

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“…Electronic tongue (e-tongue) systems present a great potential to compete, complement, or replace traditional analytical techniques. Due to their specificities: fast response times, and user-friendly operation [25,26], these devices have been used for different applications in the food industry: discrimination of the honey botanic origin [27] or in the pharmaceutical industry [28] with active pharmaceutical ingredients detection [29,30]. An e-tongue is "a multi-sensory system, formed by an array of low-selective sensors, combined with advanced mathematical procedures for signal processing, based on pattern recognition and/or multi-variate data analysis" [31].…”

Section: Introductionmentioning

confidence: 99%

Polyelectrolyte Based Sensors as Key to Achieve Quantitative Electronic Tongues: Detection of Triclosan on Aqueous Environmental Matrices

et al. 2020

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Triclosan (TCS) is a bacteriostatic used in household items that promotes antimicrobial resistance and endocrine disruption effects both to humans and biota, raising health concerns. In this sense, new devices for its continuous monitoring in complex matrices are needed. In this work, sensors, based on polyelectrolyte layer-by-layer (LbL) films prepared onto gold interdigitated electrodes (IDE), were studied. An electronic tongue array, composed of (polyethyleneimine (PEI)/polysodium 4-styrenesulfonate (PSS))5 and (poly(allylamine hydrochloride/graphene oxide)5 LbL films together with gold IDE without coating were used to detect TCS concentrations (10−15–10−5 M). Electrical impedance spectroscopy was used as means of transduction and the obtained data was analyzed by principal component analysis (PCA). The electronic tongue was tested in deionized water, mineral water and wastewater matrices showing its ability to (1) distinguish between TCS doped and non-doped solutions and (2) sort out the TCS range of concentrations. Regarding film stability, strong polyelectrolytes, as (PEI/PSS)n, presented more firmness and no significant desorption when immersed in wastewater. Finally, the PCA data of gold IDE and (PEI/PSS)5 sensors, for the mineral water and wastewater matrices, respectively, showed the ability to distinguish both matrices. A sensitivity value of 0.19 ± 0.02 per decade to TCS concentration and a resolution of 0.13 pM were found through the PCA second principal component.

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Section: Introductionmentioning

confidence: 99%

Polyelectrolyte Based Sensors as Key to Achieve Quantitative Electronic Tongues: Detection of Triclosan on Aqueous Environmental Matrices

et al. 2020

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“…Extensive surveys on the usage of those systems to food and beverage analysis [30,31], bioprocess control [32], environmental monitoring [33], and medicinal diagnosis [34] were published. Moreover, more recent reports consider the use of electronic tongues systems for pharmaceutical analysis, including the evaluation of taste-masking efficiency, dissolution tests, as well as elaboration and quality control of drugs, herbals, and medicinal plants (e.g., determination of batch-to-batch uniformity, characterization of active pharmaceutical ingredients) [35,36].…”

Section: Introductionmentioning

confidence: 99%

Critical Evaluation of Laboratory Potentiometric Electronic Tongues for Pharmaceutical Analysis—An Overview

Labanska

Ciosek-Skibińska

Wróblewski

2019

Sensors

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Electronic tongue systems equipped with cross-sensitive potentiometric sensors have been applied to pharmaceutical analysis, due to the possibility of various applications and developing new formulations. Many studies already proved the complementarity between the electronic tongue and classical analysis such as dissolution tests indicated by Pharmacopeias. However, as a new approach to study pharmaceuticals, electronic tongues lack strict testing protocols and specification limits; therefore, their results can be improperly interpreted and inconsistent with the reference studies. Therefore, all aspects of the development, measurement conditions, data analysis, and interpretation of electronic tongue results were discussed in this overview. The critical evaluation of the effectiveness and reliability of constructed devices may be helpful for a better understanding of electronic tongue systems development and for providing strict testing protocols.

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“…The EN technology can be used in human deep-space missions in order to support the health of astronauts [219] . Considering small-size compact EN devices with medical diagnostic capability, it might be implemented into the spacesuits to analyze blood, breath, saliva and measure any biomarker.…”

Section: Human Space-missionsmentioning

confidence: 99%

Electronic Nose and Its Applications: A Survey

Karakaya

Ulucan

Türkan

2019

Int. J. Autom. Comput.

266

152

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In the last two decades, improvements in materials, sensors and machine learning technologies have led to a rapid extension of electronic nose (EN) related research topics with diverse applications. The food and beverage industry, agriculture and forestry, medicine and health-care, indoor and outdoor monitoring, military and civilian security systems are the leading fields which take great advantage from the rapidity, stability, portability and compactness of ENs. Although the EN technology provides numerous benefits, further enhancements in both hardware and software components are necessary for utilizing ENs in practice. This paper provides an extensive survey of the EN technology and its wide range of application fields, through a comprehensive analysis of algorithms proposed in the literature, while exploiting related domains with possible future suggestions for this research topic.

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Critical review of electronic nose and tongue instruments prospects in pharmaceutical analysis

Cited by 117 publications

References 127 publications

Polyelectrolyte Based Sensors as Key to Achieve Quantitative Electronic Tongues: Detection of Triclosan on Aqueous Environmental Matrices

Polyelectrolyte Based Sensors as Key to Achieve Quantitative Electronic Tongues: Detection of Triclosan on Aqueous Environmental Matrices

Critical Evaluation of Laboratory Potentiometric Electronic Tongues for Pharmaceutical Analysis—An Overview

Electronic Nose and Its Applications: A Survey

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