Critical review of statins: A bio-analytical perspective for therapeutic drug monitoring

Patel, Misari; Kothari, Charmy

doi:10.1016/j.trac.2016.10.011

Cited by 27 publications

(20 citation statements)

References 93 publications

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“…[17][18][19][20] Despite reviews about quantitation of statins in pharmaceutical formulations and biological samples have been previously published, none of these reviews focused on ROS analytical methods, perhaps because it is one of the latest statins introduced in the market. [21][22][23] The aim of this review is to provide an overview of relevant published literature and a discussion of methods for the determination of ROS on its own or in mixtures, in pure form, formulations, and biological samples using different analytical procedures (HPLC-UV, LC-MS/MS, spectrophotometry, etc. ).…”

Section: Introductionmentioning

confidence: 99%

Analytical Methods for the Determination of Rosuvastatin in Pharmaceutical Formulations and Biological Fluids: A Critical Review

Ângelo

Moreira

Ruela

et al. 2018

Critical Reviews in Analytical Chemistry

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Rosuvastatin calcium (ROS), ( Figure 1 ) belongs to the "statins" group, which is the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. This drug is indicated for dyslipidemias treatment and can help to decrease the level of "bad cholesterol" and can consequently reduce the development of atherosclerosis and the risk of heart diseases. ROS was developed by Astra-Zeneca and it was approved in 2003 by the FDA in the United States. In 2015, under the trade name Crestor®, it was the fourth largest selling drug in the United States with sales above $5 billion. This study presents a literature review of analytical methods for the quantification of ROS in pharmaceutical preparations and biological fluids. The major analytical methods described in this study for ROS were spectrophotometry, high-performance liquid chromatography (HPLC) coupled to ultraviolet (UV) detection, and tandem mass spectrometry (LC-MS/MS).

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Section: Introductionmentioning

confidence: 99%

Analytical Methods for the Determination of Rosuvastatin in Pharmaceutical Formulations and Biological Fluids: A Critical Review

Ângelo

Moreira

Ruela

et al. 2018

Critical Reviews in Analytical Chemistry

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“…16 Simvastatin (SV) is used to treat hypercholesterolemia and hyperlipidemia. 17,18 Recently, it has also been reported that SV directly promotes osteoblastic differentiation and improves new bone formation by increasing the expression of bone morphogenetic protein-2 (BMP-2), alkaline phosphatase (ALP), osteocalcin and collagen type 1 (COL1) mRNAs in osteoblast-like cells and stem cells. The mechanism associated with the inuence of simvastatin on the osteogenic differentiation is not fully understood.…”

Section: Introductionmentioning

confidence: 99%

Incorporation of simvastatin in PLLA membranes for guided bone regeneration: effect of thermal treatment on simvastatin release

et al. 2018

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“…Statins specifically inhibit the enzyme HMG-CoA reductase, thereby preventing the conversion of HMG-CoA to mevalonate, which is an early rate-limiting step in cholesterol biosynthesis. Besides lipid lowering activity, statins improve endothelial function, enhance the stability of atherosclerotic plaques, decrease oxidative stress, and inhibit the thrombogenic responses [ 6 ]. Yin et al reported the LC-MS/MS method for the quantification of pitavastatin in human plasma [ 106 ].…”

Section: Cardiovascular Drugsmentioning

confidence: 99%

“…Caro et al described a review of bioanalytical methods for the therapeutic drug monitoring of β-lactam antibiotics in critically ill patients [ 1 ]. Analytical methods useful for the quantitation of statins and their metabolites in biological samples have been summarized and discussed by Patel and Kothari [ 6 ]. In 2019, researchers published a review article on the application of LC-MS/MS procedures for TDM of anti-tuberculosis drugs [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Review of Chromatographic Methods Coupled with Modern Detection Techniques Applied in the Therapeutic Drugs Monitoring (TDM)

Tuzimski

Petruczynik

2020

Molecules

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Therapeutic drug monitoring (TDM) is a tool used to integrate pharmacokinetic and pharmacodynamics knowledge to optimize and personalize various drug therapies. The optimization of drug dosing may improve treatment outcomes, reduce toxicity, and reduce the risk of developing drug resistance. To adequately implement TDM, accurate and precise analytical procedures are required. In clinical practice, blood is the most commonly used matrix for TDM; however, less invasive samples, such as dried blood spots or non-invasive saliva samples, are increasingly being used. The choice of sample preparation method, type of column packing, mobile phase composition, and detection method is important to ensure accurate drug measurement and to avoid interference from matrix effects and drug metabolites. Most of the reported procedures used liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) techniques due to its high selectivity and sensitivity. High-performance chromatography with ultraviolet detection (HPLC-UV) methods are also used when a simpler and more cost-effective methodology is desired for clinical monitoring. The application of high-performance chromatography with fluorescence detection (HPLC-FLD) with and without derivatization processes and high-performance chromatography with electrochemical detection (HPLC-ED) techniques for the analysis of various drugs in biological samples for TDM have been described less often. Before chromatographic analysis, samples were pretreated by various procedures—most often by protein precipitation, liquid–liquid extraction, and solid-phase extraction, rarely by microextraction by packed sorbent, dispersive liquid–liquid microextraction. The aim of this article is to review the recent literature (2010–2020) regarding the use of liquid chromatography with various detection techniques for TDM.

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Critical review of statins: A bio-analytical perspective for therapeutic drug monitoring

Cited by 27 publications

References 93 publications

Analytical Methods for the Determination of Rosuvastatin in Pharmaceutical Formulations and Biological Fluids: A Critical Review

Analytical Methods for the Determination of Rosuvastatin in Pharmaceutical Formulations and Biological Fluids: A Critical Review

Incorporation of simvastatin in PLLA membranes for guided bone regeneration: effect of thermal treatment on simvastatin release

Review of Chromatographic Methods Coupled with Modern Detection Techniques Applied in the Therapeutic Drugs Monitoring (TDM)

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