2003
DOI: 10.1007/s00420-003-0457-2
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Critical review of the epidemiological literature on occupational exposure to perchloroethylene and cancer

Abstract: The current epidemiological evidence does not support a conclusion that occupational exposure to PCE is a risk factor for cancer of any specific site. Priority areas in which additional data are most needed include cancers of the esophagus and bladder.

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Cited by 48 publications
(28 citation statements)
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“…33 Epidemiologic literature on these agents is, however, inconsistent and has also been criticized for methodological shortcomings. 6,13 Moreover, the results of the most The fourth digit indicates that in the Finnish FINJEM, the official census occupation was divided into subcategories according to industry. P, the proportion of exposed workers; L, the level of solvent exposure; O, observed number of liver cancer cases; E, expected number of liver cancer cases; 95% CI, 95% confidence interval; Ali, aliphatic and alicyclic hydrocarbons; Aro, aromatic hydrocarbons; Chl, chlorinated hydrocarbons; Oth, other solvents.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…33 Epidemiologic literature on these agents is, however, inconsistent and has also been criticized for methodological shortcomings. 6,13 Moreover, the results of the most The fourth digit indicates that in the Finnish FINJEM, the official census occupation was divided into subcategories according to industry. P, the proportion of exposed workers; L, the level of solvent exposure; O, observed number of liver cancer cases; E, expected number of liver cancer cases; 95% CI, 95% confidence interval; Ali, aliphatic and alicyclic hydrocarbons; Aro, aromatic hydrocarbons; Chl, chlorinated hydrocarbons; Oth, other solvents.…”
Section: Discussionmentioning
confidence: 99%
“…[2][3][4][5][6] Excesses of liver cancer have also been reported among workers potentially exposed to tetrachloroethylene, [7][8][9] but in general, the epidemiologic literature on this association is not consistent. [10][11][12][13][14] Carbon tetrachloride, chloroform and 1,2-dichloroethane have been classified as possibly carcinogenic to humans by the International Agency for Research on Cancer (IARC), and liver tumors have been detected in some animal experiments. 15 Data on the liver carcinogenicity of other types of solvents is limited.…”
mentioning
confidence: 99%
“…The neurological effects include changes in behaviour and coordination, as well as damage to the central nervous system 11) . Research is also being carried out to examine the possible connection between the exposure to tetrachloroethene of parents working at a dry-cleaner and the risk of schizophrenia in their children 12) .…”
Section: Introductionmentioning
confidence: 99%
“…A volatile organic solvent, tetrachloroethylene (a.k.a.tetrachloroethene perchloroethylene, PCE, PERC)(ATSDR), is the primary chemical used in dry cleaning since the 1950s (cited in (Mundt et al 2003)). A primary route of exposure is inhalation (ATSDR).…”
Section: Introductionmentioning
confidence: 99%