Critical review on biodegradable and biocompatibility magnesium alloys: Progress and prospects in bio-implant applications

Singh, Jashanpreet; Wahab Hashmi, Abdul; Ahmad, Shadab; Tian, Yebing

doi:10.1016/j.inoche.2024.113111

Inorganic Chemistry Communications

2024

DOI: 10.1016/j.inoche.2024.113111

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Critical review on biodegradable and biocompatibility magnesium alloys: Progress and prospects in bio-implant applications

Jashanpreet Singh,

Abdul Wahab Hashmi,

Shadab Ahmad

et al.

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Cited by 3 publications

References 141 publications

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Study on the role of functional groups of templates in the hydrothermal synthesis of hydroxyapatite on magnesium surfaces: A comparison between ethylenediamine and oxalic acid

Gao,

Li,

Gai

et al. 2025

Surface and Coatings Technology

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Study on the role of functional groups of templates in the hydrothermal synthesis of hydroxyapatite on magnesium surfaces: A comparison between ethylenediamine and oxalic acid

Gao,

Li,

Gai

et al. 2025

Surface and Coatings Technology

View full text Add to dashboard Cite

Magnesium-Titanium Alloys: A Promising Solution for Biodegradable Biomedical Implants

Sharma,

Gajević,

Sharma

et al. 2024

Materials

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Magnesium (Mg) has attracted considerable attention as a biodegradable material for medical implants owing to its excellent biocompatibility, mitigating long-term toxicity and stress shielding. Nevertheless, challenges arise from its rapid degradation and low corrosion resistance under physiological conditions. To overcome these challenges, titanium (biocompatibility and corrosion resistance) has been integrated into Mg. The incorporation of titanium significantly improves mechanical and corrosion resistance properties, thereby enhancing performance in biological settings. Mg–Ti alloys are produced through mechanical alloying and spark plasma sintering (SPS). The SPS technique transforms powder mixtures into bulk materials while preserving structural integrity, resulting in enhanced corrosion resistance, particularly Mg80-Ti20 alloy in simulated body fluids. Moreover, Mg–Ti alloy revealed no more toxicity when assessed on pre-osteoblastic cells. Furthermore, the ability of Mg–Ti-based alloy to create composites with polymers such as PLGA (polylactic-co-glycolic acid) widen their biomedical applications by regulating degradation and ensuring pH stability. These alloys promote temporary orthopaedic implants, offering initial load-bearing capacity during the healing process of fractures without requiring a second surgery for removal. To address scalability constraints, further research is necessary to investigate additional consolidation methods beyond SPS. It is essential to evaluate the relationship between corrosion and mechanical loading to confirm their adequacy in physiological environments. This review article highlights the importance of mechanical characterization and corrosion evaluation of Mg–Ti alloys, reinforcing their applicability in fracture fixation and various biomedical implants.

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Effect of Sr on Mechanical Properties and Corrosion Behavior of Rolled ZM60 Alloy

Yin,

Zhou,

Liu

et al. 2024

Materials

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Mg-6Zn-0.5Mn as a medical magnesium alloy has good biomechanical properties and corrosion resistance, but as a fracture internal-fixation material, its strength, toughness, and corrosion resistance still need to be improved. In this paper, the element Sr, having good biocompatibility, is used as an alloy element. The effects of different Sr contents (0 wt.%, 0.3 wt.%, 0.6 wt.%, 0.9 wt.%, and 1.2 wt.%) on the microstructure, strength, toughness, and corrosion resistance of rolled Mg-6Zn-0.5Mn alloy were studied. The results are as follows. Sr can influence the recrystallization process. When the Sr content is 0.3 wt.% and 0.6 wt.%, the alloy matrix exhibits both non-recrystallized regions and fine recrystallized regions. When the Sr content reaches 0.9 wt.%, the non-recrystallized region decreases significantly, and the fine recrystallized grains develop into equiaxed grains. With the increase of Sr content, the elongation of the alloy decreases. At a content of 0.9 wt.%, the corrosion resistance reaches its optimum value, with an average corrosion rate of 0.75828 mm/y.

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Critical review on biodegradable and biocompatibility magnesium alloys: Progress and prospects in bio-implant applications

Cited by 3 publications

References 141 publications

Study on the role of functional groups of templates in the hydrothermal synthesis of hydroxyapatite on magnesium surfaces: A comparison between ethylenediamine and oxalic acid

Study on the role of functional groups of templates in the hydrothermal synthesis of hydroxyapatite on magnesium surfaces: A comparison between ethylenediamine and oxalic acid

Magnesium-Titanium Alloys: A Promising Solution for Biodegradable Biomedical Implants

Effect of Sr on Mechanical Properties and Corrosion Behavior of Rolled ZM60 Alloy

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