Critical review on chemical compositions and health-promoting effects of mushroom Agaricus blazei Murill

Huang, Kaiyuan; El‐Seedi, Hesham R.; Xu, Baojun

doi:10.1016/j.crfs.2022.10.029

Cited by 15 publications

(12 citation statements)

References 75 publications

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“…High doses of BPs have been reported to arrest the osteoblast cell cycle and induce apoptosis, consequently reducing osteoblast lineage proliferation 5 . Our previous research has also demonstrated the detrimental effect of BRONJ on osteoblasts and the Wnt pathway 6 , 32 , 33 . However, the intriguing effect of PAb gel on osteoblasts observed in this study can be attributed to its ability to enhance osteoblast adhesion, growth, and proliferation 34 .…”

Section: Discussionmentioning

confidence: 90%

Polysacharide of Agaricus blazei gel mitigates bone necrosis in model of the jaws related to bisphosphonate via Wnt signaling

Costa de Sousa,

Nunes Sousa,

Felipe Vasconcelos

et al. 2024

Sci Rep

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To investigate de effect of PAb gel on the bone tissue of rats submitted to Bisphosphonate-related osteonecrosis of the jaws (BRONJ). Initially, 54 animals were submitted to BRONJ model by Zoledronic Acid (ZA) (0.1 mg/kg 3x/wk for 9 wk, ip), followed by the 1st upper left molar extraction at the 8th wk. After tooth removal, the animals were divided into 3 groups, ZA that received placebo gel or PAb gel that received 1% PAb gel, inside the dental alveolus. The control Group (CONTROL) received 0.1 mg/kg of 0.9% saline and then placebo gel. Three weeks after tooth extraction, the animals were euthanized, and maxillae were colleted for macroscopic, radiographic, histological and Raman spectomery assays. Additionally, GSK3b, beta-catenin, and Runx2 mRNA expressions were determined. Blood samples were collected for the analysis of Bone-specific alkaline phosphatase (BALP) levels. PAb gel improved mucosal healing, increased the number of viable osteocytes, while it reduced the number of empty lacunae, as well as the amount of bone sequestration. Furthermore, PAb gel positively influenced the number and functionality of osteoblasts by stimulating Wnt signaling, thereby inducing bone remodeling. Additionally, PAb gel contributed to improved bone quality, as evidenced by an increase in bone mineral content, a decrease in bone solubility, and an enhancement in the quality of collagen, particularly type I collagen. PAb gel mitigated bone necrosis by stimulating of bone remodeling through Wnt signaling and concurrently improved bone quality. PAb gel emerges as a promising pharmacological tool for aiding in BRONJ therapy or potentially preventing the development of BRONJ.

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Section: Discussionmentioning

confidence: 90%

Polysacharide of Agaricus blazei gel mitigates bone necrosis in model of the jaws related to bisphosphonate via Wnt signaling

Costa de Sousa,

Nunes Sousa,

Felipe Vasconcelos

et al. 2024

Sci Rep

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“…It is worth noting that most investigations have evaluated the biological activity of ABM polysaccharides based on its crude extracts, 21,37,38 and at least more than five kinds of distinct homogeneous polysaccharides were identified from the crude extracts. 39 Regrettably, the isolation and purification of these polysaccharides were still unaccomplished as well as the characteristics of their structure, which restrained the further development and application of ABM polysaccharides. In the present study, we purified the major homogeneous polysaccharide from ABM and performed physicochemical characterizations.…”

Section: ■ Discussionmentioning

confidence: 99%

Polysaccharide Isolated from Agaricus blazei Murill Alleviates Intestinal Ischemia/Reperfusion Injury through Regulating Gut Microbiota and Mitigating Inflammation in Mice

Zhao,

Tang,

Huang

et al. 2024

J. Agric. Food Chem.

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Intestinal ischemia–reperfusion (I/R) injury is a serious disease in medical settings, and gut dysbiosis is a major contributor to its development. Polysaccharides from Agaricus blazei Murill (ABM) showed a range of pharmacological activities, yet no studies assessed the potential of ABM polysaccharides for alleviating intestinal I/R injury. Here, we purified a major polysaccharide (ABP1) from an ABM fruit body and subsequently tested its potential to mitigate intestinal I/R injury in a mouse model of temporary superior mesenteric artery occlusion. The results reveal that ABP1 pretreatment enhances gut barrier function via upregulation of the expression of tight junction proteins such as ZO-1 and occludin. Additionally, ABP1 intervention reduces the recruitment of neutrophils and the polarization of M1 macrophages and limits inflammation by blocking the assembly of the NLRP3 inflammasome. Moreover, the role of ABP1 in regulating the gut microbiota was confirmed via antibiotic treatment. The omics data reveals that ABP1 reprograms gut microbiota compositions, characterized by a decrease of Proteobacteria and an increase of Lachnospiraceae and Lactobacillaceae, especially the SCFA-producing genera such as Ligilactobacillus and Blautia. Overall, this work highlights the therapeutic potential of ABP1 against intestinal I/R injury, which mainly exhibits its effects via regulating the gut microbiota and suppressing the overactivated inflammation response.

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“…However, this does not imply that the antioxidant activity of Agaricus mushrooms is insignificant. In fact, Agaricus mushrooms are a natural source of antioxidants, with their polysaccharide components serving as natural antioxidants that exhibit commendable antioxidant effects. , …”

Section: Biological Activitiesmentioning

confidence: 99%

“…In fact, Agaricus mushrooms are a natural source of antioxidants, with their polysaccharide components serving as natural antioxidants that exhibit commendable antioxidant effects. 45,49 3.3. Other Biological Activities.…”

Section: Antitumor Activitymentioning

confidence: 99%

Chemical Structures, Biological Activities, and Biosynthetic Analysis of Secondary Metabolites from Agaricus Mushrooms: A Review

Zhang,

Zhao,

Tang

et al. 2024

J. Agric. Food Chem.

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Agaricus mushrooms are an important genus in the Agaricaceae family, belonging to the order Agaricales of the class Basidiomycota. Among them, Agaricus bisporus is a common mushroom for mass consumption, which is not only nutritious but also possesses significant medicinal properties such as anticancer, antibacterial, antioxidant, and immunomodulatory properties. The rare edible mushroom, Agaricus blazei, contains unique agaricol compounds with significant anticancer activity against liver cancer. Agaricus blazei is believed to expel wind and cold, i.e., the pathogenic factors of wind and cold from the body, and is an important formula in traditional Chinese medicine. Despite its nutritional richness and outstanding medicinal value, Agaricus mushrooms have not been systematically compiled and summarized. Therefore, the present review compiles and classifies 70 natural products extracted from Agaricus mushrooms over the past six decades. These compounds exhibit diverse biological and pharmacological activities, with particular emphasis on antitumor and antioxidant properties. While A. blazei and A. bisporus are the primary producers of these compounds, studies on secondary metabolites from other Agaricus species remain limited. Further research is needed to explore and understand the anticancer and nutritional properties of Agaricus mushrooms. This review contributes to the understanding of the structure, bioactivity, and biosynthetic pathways of Agaricus compounds and provides insights for the development of functional foods using these mushrooms.

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Critical review on chemical compositions and health-promoting effects of mushroom Agaricus blazei Murill

Cited by 15 publications

References 75 publications

Polysacharide of Agaricus blazei gel mitigates bone necrosis in model of the jaws related to bisphosphonate via Wnt signaling

Polysacharide of Agaricus blazei gel mitigates bone necrosis in model of the jaws related to bisphosphonate via Wnt signaling

Polysaccharide Isolated from Agaricus blazei Murill Alleviates Intestinal Ischemia/Reperfusion Injury through Regulating Gut Microbiota and Mitigating Inflammation in Mice

Chemical Structures, Biological Activities, and Biosynthetic Analysis of Secondary Metabolites from Agaricus Mushrooms: A Review

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